The evolution of multicellular organisms represents one of approximately eight major evolutionary transitions that have occurred on earth [1-4]. The major challenge raised by this transition is to explain why single cells should join together and become mutually dependent, in a way that leads to a more complex multicellular life form that can only replicate as a whole. It has been argued that a hi

Introduction. Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim. To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods. Consensus discussion over the past 18 months le

The Child Feeding Questionnaire (CFQ) assesses parental feeding attitudes, beliefs and practices concerned with child feeding and obesity proneness. While the questionnaire has been developed and primarily used in the U.S., validation studies in other countries are limited. The aim of this study was to examine the psychometric properties of the CFQ among mothers with preschoolers in Sweden and the

In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined. The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships w

Microbially induced sedimentary structures (MISS) in siliciclastic shallow-marine strata occur in the lower and middle Cambrian and the Silurian of southern Sweden. These are typically transparent wrinkle structures with a wide range of morphologies. They are exclusively associated with shoreface to lower shoreface environments, characterized by fine-grained sandstone interbedded with mudstone and

To validate the Swedish Register for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks) concerning completeness and correctness of entered data for cholecystectomies and evaluating the effect of repeated audits. It is crucial for any register to obtain a high accuracy in order to be a credible and reliable source for quality evaluation, research, and development.

Capacity improvement of intrasite cooperative MIMO using all three 120 degree-sectors of a base station (BS) site is studied for the first time in a measured urban environment at 2.65GHz. The results show that the mean uplink capacity gain exceeds 40% in as much as 1/4 of the coverage area, relative to the best single-sector link with no cooperation. In addition, a simple simulation model is devel

A high-order accurate, explicit kernel-split, panel-based, Fourier–Nyström discretization scheme is developed for integral equations associated with the Helmholtz equation in axially symmetric domains. Extensive incorporation of analytic information about singular integral kernels and on-the-fly computation of nearly singular quadrature rules allow for very high achievable accuracy, also in the ev

Serotonin (5-HT), an important modulator of both sensory and motor functions in the mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. However, following complete transection of the spinal cord, small amounts of 5-HT remain detectable below the lesion. It has been suggested, but not proven, that this residual 5-HT is produced by intraspinal 5-HT neurons. Here, we show b

According to our current cosmological model, galaxies like the Milky Way are expected to experience many mergers over their lifetimes. The most massive of the merging galaxies will be dragged towards the disc plane, depositing stars and dark matter into an accreted disc structure. In this work, we utilize the chemodynamical template developed in Ruchti et al. to hunt for accreted stars. We apply t

Introduction: The diagnosis of acute lung injury (ALI) may be more robust if more accurate physiological markers can be identified. Extravascular lung water (EVLW) is one possible marker, and it has been shown to correlate with respiratory function and mortality in patients with sepsis. Whether EVLW confers diagnostic value in a general population with shock, as well as which index performs best,

An integrated study of palynology, Mossbauer spectroscopy, mineralogy and osmium isotopes has led to the detection of the first K-Pg boundary clay layer in a Southern Hemisphere terrestrial setting. The K-Pg boundary layer was independently identified at centimetre resolution by all the above mentioned methods at the marine K-Pg boundary site of mid-Waipara and the terrestrial site of Compressor C

The aim of this study was to evaluate nerve regeneration in relation to the transcription factor, Activating Transcription Factor 3 (ATF 3), and an apoptotic marker, caspase 3, in the Schwann cells of diabetic BB rats (i.e. display type 1 diabetes phenotype). Sciatic nerves in healthy Wistar rats and in diabetic BB rats were transected and immediately repaired. Axonal outgrowth (neurofilament stai

The cellular hallmarks of Parkinson's disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric nervous system and spread

G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans. We examined the localization of GIRK2 in the SN and adjacent ventral tegmental area (VTA) of humans and mice by using either neuromelanin pigment or immunolabeling with tyrosine hydroxylas

Introduction Oesophageal stricture is a frequent complication following repair of oesophageal atresia (EA). The aim of this study was to conduct a pre- and postintervention study and analyze the incidence of stricture formation and need for balloon dilatation after introducing prophylactic proton pump inhibitor (PPI) treatment.Children and Design All children operated for EA during 2001 to 2009 (n

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA targets. A KTS insertion due to alternative splicing between the zinc fingers 3 and 4 and an unconventional zinc finger 1 are the unique features that

Resource reservation is a technique that allows isolating applications from interfering among each other. In the most classic setting, this method requires the periodic allocation of a given budget of resource over time. However, in reality, the actual budget allocation may deviate from its ideal value. Examples of causes of this deviation are: the presence of a system tick, the usage of shared re