Some 4 billion years ago, nature began the experiment that led to you, that bird on the branch, that branch, and everything else which is alive that you see around you. The generating process of all this splendid life is, of course, evolution. Evolution works not only on the macroscopic scale (think eyes, muscles, wings) but also on the molecular scale (think molecular antennas, nanoscale muscles,The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design

Abstract: Cardiovascular diseases and diabetes mellitus are closely linked by sharing common risk factors, such as obesity, insulin resistance, hypertension and dyslipidaemia. These intermediate risk factors are affected by the joint effects of environment and genetics. Although a multitude of studies aimed to disentangle the effects of gene-environment interactions, many of the published gene-en

Since 1772, members of the Royal Swedish family have been granted titular duchies among the historical provinces of Sweden. The right to choose a duchy for a prince, and since 1980, for a princess that is heir to the throne, lies with the King. Central and important provinces with majestic heraldic symbols have been chosen to a greater extent than smaller and more peripheral provinces with less ma

This presentation highlights results from a research study of ‘Music Week’; a one-week Swedish music project. The aim of the ‘Music Week’ project was to enable young people with physical impairments to take part in musical activities. Digitally-based musical settings were used in order to provide tools for performing and creating music. The main purpose of the present research study was to explore

This presentation highlights results from an action research project in a Swedish primary school. The aim of the project is to investigate digitally-based musical settings with young children in need of special support. Various digital-based music instruments were used to facilitate performing, creating and learning music, alone or in small groups. The theoretical background of the project is foun

I Can Play! -– Digitally- based musicking with children in need of special supportThis presentation highlights preliminary results from an ongoing action research project in a Swedish primary school. The aim of the project is to develop and test digitally-based musical settings with young children in need of special support. Computers, iPads and synthesizers were used in order to facilitate for th

Music is used in many professional contexts that are not associated, in a traditional sense, with either music therapy or music education. How do professionals in different contexts use music, and how do they describe their thoughts about music in their professional work? Those are the main questions in our inquiry, focusing on narratives about music and health in professional relations. In this p

Purpose: Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Methods: Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Hom

Heteroleptic iron based complexes bearing the 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine motif and a polypridine ligand have been synthesized and characterized in their ground and excited state. This series of complexes includes a first example of a hetero-bimetallic complex connecting an iron N-heterocyclic carbene photosensitizer with a cobalt dimethylglyoxime fragment. Focus i

BackgroundThe forest biorefinery plays an important part in the evolving circular bioeconomy due to its capacity to produce a portfolio of bio-based and sustainable fuels, chemicals, and materials. To tap into its true potential, more efficient and environmentally benign methods are needed to fractionate woody biomass into its main components (cellulose, hemicellulose, and lignin) without reducing

The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between t

Length-of-stay (LOS) is a key parameter in destination management that determines the number of guest nights relative to arrival numbers, with concomitant repercussions for revenue generation and other performance indicators. This article investigates the development of LOS for 32 destinations in developed and emerging economies as well as Small Islands and Developing States (SIDS). The analysis i

The Paris Climate Agreement is based on pledges from 195 countries to substantially reduce emissions of greenhouse gases (GHG) to prevent dangerous climate change. The tourism sector has likewise pledged to reduce its GHG emissions (−70% by 2050); however, current emission trends would result in a tripling in the same timeframe. In order to understand how the sector understands the decarbonisation

Hydrotropic extraction (HEX) is a method for the delignification of lignocellulose that has been given increasing amounts of attention during the last couple of years. A hydrotrope is an amphiphilic substance, which, in high enough concentrations, can improve solubility of otherwise poorly soluble substances in water. The most commonly used substance for HEX-delignification is sodium xylenesulfona

The forest industry is one of Sweden’s most important business areas. As the use of paper is declining the need for this sector to find other alternatives is increasing. An attractive option to meet this demand is the establishment of forest biorefineries. However, economically suitable pretreatment methods for woody biomass, which minimize degradation of the structural carbohydrates and allow the

Background: Frailty is considered highly prevalent among the aging population. Fruit and vegetable intake is associated with positive health outcomes across the life-span; however, the relationship with health benefits among older adults has received little attention. Aim: The aim was to examine if a relationship exists between meal frequency or frequency of vegetable intake and the development of

This paper explores trade connections – or the lack of such – between copperworks and copper processing plants in the Oldenburg Monarchy in the eighteenth century. Domestic customs areas, high tariffs on raw material export and import bans sought to encourage domestic copper and brass goods production of Norwegian copper raw material, however this was only realised halfway. The raw material from N