Diffusion MRI in the cortex of the brain : Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding
Purpose: The mean diffusivity (MD) is sensitive to the microstructure of the cortex. However, partial volume effects with CSF and white matter (WM) may obscure pathology-related alterations. This work investigates both existing approaches and a novel approach for reducing partial volume effects. Theory and Methods: A bias in MD arises due to partial volume effects, higher-order terms, and the nois
