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pH dependency of ligand binding to cellobiohydrolase 1 (Cel7A) - Affinity, selectivity and inhibition for designed propranolol analogues

The affinity and enantioselectivity have been determined for designed propranolol derivatives as ligands for Cel7A by capillary electrophoresis (CE) at pH 7.0. These results have been compared to measurements at pH 5.0. In agreement with previous studies, the affinity increased at the higher pH. However, the affinity was not as dependent of the ligand structure at pH 7.0 as at pH 5.0, and the sele

Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone

Context: The impact of long-term GH replacement on cerebrovascular and cardiovascular diseases and diabetes mellitus in hypopituitary patients is unknown. Objective: The incidence of nonfatal stroke and cardiac events, and prevalence of type 2 diabetes mellitus ( T2D) and cardioprotective medication were compared between cohorts of GH-deficient (GHD) patients and population controls. Design and Pa

Ariadne at HERA and at the LHC

I describe briefly the status of the ARIADNE program implementing the Dipole Cascade Model and comment both on its performance at HERA, and the uncertainties relating to the extrapolation to LHC energies.

The multiple meaning of home as experienced by very old Swedish people

he aim of this study was to explore aspects of the meaning of home as experienced by very old single-living people in Sweden. A grounded theory approach was used, and interviews were conducted with 40 men and women aged 80-89. The findings indicate that home has a central place in the lives of very old people because it is where they live and spend so much time. The significance of the home is bas

Limiter-free third order logarithmic reconstruction

A third order conservative reconstruction, in the context of finite volume schemes for hyperbolic conservation laws, is constructed based on logarithmic functions. This logarithmic method reconstructs without the use of a limiter, any preprocessing of input data, special treatments for local extrema, or shock solutions. Also the method is local in the sense that data from only the nearest neighbor