Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convertase subtilisin/kexin type 9 (PCSK9) (rs562556, V474I) that is associated with reduced survival in multiple breast cancer patient cohorts. Genetic modeling of this gain-of-function single-nucleotide variant in mice revealed that it causally promotes b

Peatlands are often considered carbon pools as they are critical components of the carbon cycle process. Evaluating conditions of the peatlands is important for climate change impact studies as there is a close correlation between the peat accumulation, carbon sequestration, and water depth of the peatlands. Hence, accurate and continuous monitoring of their conditions is crucial to evaluate carbo

Significant groundwater (GW) head decline due to excessive withdrawal is an essential hydrological concern in several major plains of Iran. The capacity of an aquifer to retain GW can be described through the storativity parameters. Traditional methods to define these parameters are costly, time-consuming, and sometimes ineffective. The storativity of an aquifer, irrespective of its confinement ty

The COVID-19 pandemic challenges expectations of retirement. In this paper, we ask: How is the retirement transition experienced in the everyday lives of older adults during pandemic as compared to pre-pandemic times? The paper draws on 15 semi-structured interviews with adults aged 60–75 years living in Germany within the first year of the COVID-19 pandemic, which were analyzed based on social co

Today, the concept of security manifests itself in a number of forms in most scientific, social, environmental, and political issues. One of the most essential and prominent types of security issue faced today is water security, which has introduced a complex and new concept to the literature of today’s world. Not only has the current water crisis in most parts of the world increased the risk of m

Improper utilization of water resources has the potential to result in reduced availability of high-quality water and adverse effects on societal development. In fact, what appears to be a serious gap in comprehensive water resources studies is the lack of a coherent approach that can link different social, economic and environmental parts within the framework of the integrated water management pa

This study presents a novel approach for object detection and tracking in aerial images using a multi-scale Northern Goshawk Pyramid Generative Adversarial Network (NGPGAN). The research evaluates different algorithms and features to identify people, trees, cars, and buildings in real-world drone videos, addressing challenges in pinpointing specific objects among multiple entities. Object detectio

https://www.svenskpsykiatri.se/wp-content/uploads/2024/12/SP-nr-4-2024-till-hemsidan.pdf

One-stop-shop (OSS) business models offering integrated renovation services, making renovation more affordable and feasible, are a requirement of European Union policies aiming in energy efficiency in buildings. The present paper offers an ex-ante (pre-implementation) and ex-post (post-implementation) evaluation of 37 OSS business models currently operating in the EU renovation market. The evaluat

The first issue of Journal for Person-Oriented Research (JPOR) was published in 2015, representing the first international journal specifically focused on person-oriented research. With this issue, the JPOR completes its tenth yearly volume. The status of JPOR as a truly international journal is reflected in the number of published articles from different countries. The number of submissions to JP

The purpose of the present chapter is to outline the principles of experimental phenomenology as an approach to research on spirituality. Experimental phenomenology is the investigation of phenomenological practices and their impact. Essential to phenomenological practices is that they involve intentional variations of experiencing by means of changes in the direction of attention and the choice o

Direct oral anticoagulants (DOAC) are increasingly common, with bleeding events associated with elevated plasma concentrations. Rotational thromboelastometry (ROTEM), a point-of-care tool for assessing secondary hemostasis, has demonstrated a correlation with increasing concentrations of DOAC. However, previous studies have only partially explored this relationship. The primary aim in the current

Ageing societies are facing major housing challenges. Understanding and addressing older adults' diverse housing needs and preferences are crucial. Having access to suitable and sustainable housing options can improve social cohesion, independence, health, and well-being. Participatory processes in housing development can enhance inclusion and democratic participation. This study uses Ramlösa Port

With the amendment to the German Climate Change Act in 2021, the Federal Government of Germany has set the target to become greenhouse gas neutral by 2045. Reaching this ambitious target requires multisectoral efforts, which in turn calls for interdisciplinary collaboration: the Net-Zero-2050 project of the Helmholtz Climate Initiative serves as an example of successful, interdisciplinary collabor

Avimplementering är en nödvändig och utmanande process inom socialt arbete. Den innebär att ta bort eller avsluta användningen av metoder eller praxis som är ineffektiva, skadliga eller inte längre kostnadseffektiva. Artikeln baseras på en studie i Sverige av implementering av två evidensbaserade metoder. Forskarna har genomfört en survey, gjort litteraturstudier och fallstudier. Resultaten visar

Introduction: Although antiretroviral therapy (ART) leads to reduced tuberculosis (TB) incidence in people with HIV (PWH), ART recipients remain at higher risk of TB compared to HIV-seronegative people. With accelerated ART rollout in sub-Saharan Africa, increasing proportions of TB cases among PWH in people receiving long-term ART have been reported. Objective: To determine TB notifications among

Grade is an important determinant of progression in non–muscle-invasive bladder cancer. Although the World Health Organization (WHO) 2004/2016 grading system is recommended, other systems such as WHO1973 and WHO1999 are still widely used. Recently, a hybrid (three-tier) system was proposed, separating WHO2004/2016 high grade (HG) into HG/grade 2 (G2) and HG/G3 while maintaining low grade. We asses