Popular Abstract in Swedish Depression är en mycket vanlig och allvarlig sjukdom som drabbar ett stort antal människor någon gång i livet. På jakt efter effektiv antidepressiv behandling har forskare inom det medicinska fältet sökt efter biologiska processer kopplade till sjukdomen. På senare tid har ett flertal undersökningar visat att depression leder till förändringar inom vissa områden av hjärThe aim of the current thesis was to investigate glial responses to electroconvulsive seizures (ECS), an animal model of the fast-acting antidepressant treatment electroconvulsive therapy (ECT). Depression, a common and devastating disorder, has in recent years been associated with volumetric changes in prefrontal cortex, hippocampus and amygdala, brain regions known to be implicated in emotional

The aim of this study was to describe employers experiences of a work rehabilitation planning process at the workplace and how it can be improved according to quality and cost-effectiveness. Qualitative interviews were performed with 10 employers of employees that had participated in in vocational rehabilitation at a rehabilitation centre in the north of Sweden.The results showed that employers we

Popular Abstract in Swedish Utbredningen av besvär som attribueras till elektrisk utrustning respektive kemikalielukter och andra odörer är ännu ej till fullo fastställd. Vidare saknas kunskap om eventuella bakomliggande faktorer för dessa besvärs uppkomst. Syftet med avhandlingen var att undersöka utbredningen av besvär som attribueras till elektriska faktorer, kemikalier och lukter, samt undersSelf-reported annoyance from electrical equipment has been in evidence since the mid-eighties, and the first reports of illness from everyday chemicals arose already in the 1960?s. However, the extent of the problem or the mechanisms behind the development of environmentally related annoyance has not yet been fully established. Increased vulnerability to stress has been suggested to be a possible

Do the CNS monoaminergic (MA) systems regulate thyroid hormone metabolism in humans? In 23 unmedicated, male, violent offenders without signs of thyroid disease, we found positive correlations between the catecholaminergic CSF metabolites HVA and MHPG and the peripheral T3/T4 ratio (rho=0.55, p=0.010 and 0.51, p=0.018), indicating that increased activity in the brain MA systems, especially the dop

The desert gerbil Psammomys obesus, an established model of type 2 diabetes (M), has previously been shown to lack pancreatic and duodenal homeobox gene 1 (Pdx-1) expression. Pdx-1 deficiency leads to pancreas agenesis in both mice and humans. We have therefore further examined the pancreas of P. obesus during embryonic development. Using Pdx-1 antisera raised against evolutionary conserved epitop

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The objectives of this paper are to identify in-vehicle systems for speed management that have been or are being developed, and to suggest recommendations for the implementation of systems that will effectively influence driving speeds and thereby significantly increase safety. The best safety effect is expected from an "intelligent" gas pedal, more specifically the automatic speed limiter. Howeve

OBJECTIVE: To determine costs of illness for adult diabetes mellitus (DM), including complications caused by DM. DESIGN: A population-based multicentre cross- sectional study including an interview and a physical examination of patients identified as having DM. The patients' medical records were analysed regarding diagnoses and complications attributable to DM. SETTING: Eight health care centres o

A recently constructed long-path enclosive flow cooling apparatus is employed to obtain the Fourier transform gas-phase infrared absorption spectrum of natural isotopic trans-1,2-dichloroethylene with a resolution of 0.00190 cm(-1) in the 800-1000 cm(-1) spectral region. The rotational structure of the out-of-plane CH flapping fundamental has been analyzed for the isotopic analogues Cl-35(2) and (

Z(SPA-1) is an engineered protein that binds to its parent, the three-helix-bundle Z domain of staphylococcal protein A. Uncomplexed Z(SPA-1) shows a reduced helix content and a melting behavior that is less cooperative, compared with the wild-type Z domain. Here we show that the difference in folding behavior between these two sequences can be partly understood in terms of an off-lattice model wi

An analytical method for the analysis of 3-aminopropionamide (3-APA) based on derivatization with dansyl chloride and liquid chromatography/fluorescence detection was developed. We have analysed 3-APA formation in raw potatoes, grown and stored under different condition, green and roasted coffee beans and in freeze dried mixtures of asparagine with sucrose and glucose in molar ratio of 1:0.5, 1: 1

We have performed a joint theoretical and experimental study to investigate the terahertz radiation from Bloch oscillations in a GaAs/Al0.3Ga0.7As superlattice under the condition that there is no Zener tunneling. The total radiation intensity has been calculated with a semiclassical approach in the low field regime where the Wannier-Stark ladder (WSL) cannot be resolved, and with an exact numeric

The findings from the Prostate Cancer Prevention Trial (PCPT) and how they relate to the management of prostate disease were reviewed by leading European urologists during a meeting held in December 2005. The consensus opinions that were reached were endorsed by the European Association of Urology and are documented here. The key points of the consensus are as follows: (1) The overall results from