CRISPR är en revolutionerande teknik som möjliggör effektiv redigering av DNA.Kliniska studier med CRISPR-baserade terapier för blodsjukdomar och cancer pågår redan.Framtida tillämpningar av CRISPR kan förväntas bli breda men förutsätter etiska, juridiska och hälsoekonomiska överväganden.

Lung transplantation is an accepted treatment for end stage lung diseases and performed at two national centers in Sweden - Gothenburg and Lund. Since the start in 1990 over 1 200 patients have been transplanted. The indications are severe progressive lung diseases with short expected survival or severe negative effects on daily life. There are several contraindications among which severe other or

Phimosis in boys is a common condition. In the majority of cases it is physiological without symptoms. Symptomatic phimosis can often be treated successfully with local steroid cream - only a minority of patients need surgery. This study concludes that diagnosis, information to patients and guardians, initiation and follow-up of local steroid treatment can successfully, and safely, be delegated to

India is one of the most diverse media economies in the world and presents incredible opportunities for research in the field of media economics and management. At this point in time, we find that the often scattered contours of this area to some extent are a result of its checkered history and salience within the larger field of communication studies. All this has resulted in only a limited set o

Electric road systems (ERS) allows electric vehicles to charge while in motion, in turn possibly reducing the cost of the vehicle since the battery capacity can be reduced. Most conductive ERS seen today are DC and while static charging is possible from an ERS it is also often beneficial if the vehicle is able to charge from the AC grid as well. In this paper an electric powertrain with the chargi

This paper presents theoretical and practical analyses of four different design options for an electrically excited synchronous machine (EESM) with hollow field winding conductors for internal air cooling. This cooling concept allows for effective direct cooling of the windings.Simulations are performed for the electromagnetic evaluation of the proposed designs, while a plastic 3D printed rotor mo

The market for partly or fully electrified vehicles is expanding fast. The number of sources and loads that are connected to the vehicles traction voltage systems (TVS) increase and thus also the EMC requirements on these sources and loads. These requirements should make sure that neither function nor lifetime of any source or load is severely affected by another. The EMC requirements include both

We sequenced multiple genes from the enigmatic genera Bhagadatta Moore, 1898, Kumothales Overlaet, 1940 and Harmilla Aurivillius, 1892 (Nymphalidae, Limenitidinae) and analysed them together with a large published dataset. We find that Bhagadatta is sister to the genera Cymothoe Hübner, 1819+Harma Doubleday, 1848, and that Kumothales is sister to these three. Harmilla is nested within the genus Eu

We report nonlinear pulse compression of 1.2-ps, 2-mJ pulses. For spectral broadening, we use a Kr-filled Herriott-type cell with 22-roundtrips. After a chirped-mirror compressor, we measure 30-fs pulses, 80% transmission and an M2 of 1.5×1.7.

Opinion mining on social media posts has become more and more popular. Users often express their opinion on a topic not only with words but they also use image symbols such as emoticons and emoji. In this paper, we investigate the effect of emoji-based features in opinion classification of Uzbek texts, and more specifically movie review comments from YouTube. Several classification algorithms are

Eulophidae is a hyper-diverse family of chalcidoid wasps with 324 genera, about 5300 described species and probably thousands of others to be described. Until now, the absence of unequivocal morphological apomorphies and the low resolution provided by the handful of Sanger sequenced genes have hampered the reconstruction of phylogenetic relationships within the family. Here, we used ultra-conserve

IntroductionMulti‐component T2 mapping using a gradient‐ and spin‐echo (GraSE) acquisition has become standard for myelin water imaging at 3 T. Higher magnetic field strengths promise signal‐to‐noise ratio benefits but face specific absorption rate limits and shortened T2 times. This study investigates compartmental T2 times in vivo and addresses advantages and challenges of multi‐component T2 map

In insects airborne odors are detected by the odorant receptors (ORs) and ionotropic receptors (IRs), located on the dendritic membrane of the olfactory sensory neurons (OSNs) housed in olfactory sensilla. The OR and IR gene families show high plasticity in lineage expansion and contraction following the birth-and-death evolutionary model. Gene duplication is an important mechanism underlying the

Additions B and E to LXX Esther have been variously dated from the second century BCE to the first century CE. This study links the two Greek Additions, on the one hand, with Philo’s writings through the concept of the “evil-hating justice” and, on the other hand, with the historical persons and events related to the Jewish-Alexandrian conflict of 38-41 CE, and dates their composition or final red

This article is focused on gender mainstreaming at Swedish universities in the period from 2016–2019. Our research questions are: (a) In what form was gender mainstreaming introduced and did the form itself affect scholar’s academic rights? (b) Was the process in question compatible with international standards of institutional autonomy? (c) What effect did gender mainstreaming have on scholars’ a

Hygric properties of porous building materials are important for hygrothermal analysis. Their experimental determination is however not always reliable, shown by the discrepant results from different laboratories on the same materials. In this study, a recent round robin campaign initiated by KU Leuven (Belgium) and participated in by eight institutes from different countries is reported. Ceramic

Abstract: The sintering of cubic boron nitride (cBN) based ceramic matrix materials with zirconium carbide and aluminum has been carried out under high pressures and temperatures. The performed study has revealed that the interaction between mixture components with the formation of a new phase, namely, zirconium diboride (ZrB2) occurs at sintering temperatures above 1750°C and an applied pressure

Land use is affecting 70% of global ecosystems and their functioning. Forest management is a regionally dominant land use and affects forest ecosystems by changing both structure and functioning, but its impact on primary productivity is not well known. Here we investigated the effect of forest management on primary productivity by comparing managed secondary forests with relatively pristine unman