Strategies to design clinical studies to identify predictive biomarkers in cancer research

The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promisi

Antimicrobial combination treatment including ciprofloxacin decreased the mortality rate of Pseudomonas aeruginosa bacteraemia : a retrospective cohort study

Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regim

Development of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic area

Background: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. Results: Using the flow cytometry technique for detection of P. falciparum specific (Pf+) B-cells, this study for the first time measured the development of Pf+ B cell (CD19+) phenotypes in Ugandan babies from birth

Heliga föremål och religiösa ting

En unik samling medeltida skatter från skånska kyrkor finns bevarade till våra dagar. Dessa liturgiska föremål som använts i gudstjänstens cermoniel, beskrivs här i ord och bild. Guldsmedernas och bronsgjutarnas praktfulla alster belyses utifrån sin funktion och sitt stilhistoriska sammanhang. Personliga ägodelar såsom smycken och pilgrimsmärken ger oss samtidigt en inblick i hur den kristna kultu

Färlöv och Färlövsholm : medeltida huvudgårdsmiljöer i Helgeådalen : inledande observationer

Ett nyupptäckt medeltida stenhus i Färlövs kyrkby, Östra Göinge, blev hösten 2011 föremål för en kortvarig, inledande undersökning. En välbevarad, aristokratiskt präglad anläggning har börjat framträda, i ett läge strax väster om Färlövs romanska stenkyrka med sina välkända tvillingtorn. En medeltida huvudgård i kyrkbyn är känd i dokumenten, och här finns ett ännu något oklart men intressant samba

Cells of Innate and Adaptive Immunity : A Matter of Class?

Coeliac disease and invasive pneumococcal disease : a population-based cohort study

Severe infections are recognized complications of coeliac disease (CD). In the present study we aimed to examine whether individuals with CD are at increased risk of invasive pneumococcal disease (IPD). To do so, we performed a population-based cohort study including 29 012 individuals with biopsy-proven CD identified through biopsy reports from all pathology departments in Sweden. Each individual

Intracellular Clearance by Nobel Laureates

The Origin of a Paradigm

Gone with the Wind--Innate Immunity and Airway Inflammation

Nobel Parasites in the Kingdom of Invertebrates

The Neutrophil : A Beautiful Beast or a Beastly Beauty?

Back to the Present

Foodies of Innate Immunity

Interferon-λ : Inters Ferocity or Inter-Ferocities?

All that glisters is not gold - Staphylococcus aureus and innate immunity

Chasing flies because time flies

The Janus face of macrophages in immunity

Unexpected and novel functions of complement proteins

Surveillance and countermeasures in innate immunity