During human embryogenesis, distinct waves of hematopoiesis give rise to various blood cell types, originating from hemogenic endothelial (HE) cells. As HE cells reside in hypoxic conditions in the embryo, we investigated the role of hypoxia in human endothelial to hematopoietic transition and subsequent hematopoiesis. Using single-cell RNA sequencing, we describe hypoxia-related transcriptional c

AU The:information Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly contained in population genomic data can tell : us much about the past ecology and evolution of species. We leveraged detailed phenotypic and genomic data of nearly all living kākāpō to understand the evolution of its feather color polymorphism. The kākāpō is an endangered and culturally significant parrot endemic to Aotea

Background: In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidence of KRT, kidney transplantation activity, mortality and prevalence of KRT across Europe. Methods: Patients receiving KRT were included from 17 countries provid

Purpose: To examine health-related quality of life (HRQoL) and supportive care needs among young adult (YA) cancer survivors up to 3 years post-diagnosis. Methods: A national cohort of individuals diagnosed at 18–39 years with breast, cervical, ovarian, or testicular cancer, lymphoma or brain tumor was approached with surveys at 1.5 (n = 1010, response rate 67%) and 3 (n = 722) years post-diagnosi

Context. The nuclear stellar disc (NSD) is a flat and dense stellar structure at the centre of the Milky Way. Previous work has identified the presence of metal-rich and metal-poor stars in the NSD, suggesting that they have different origins. The recent publication of photometric, metallicity, proper motion, and orbital catalogues allows the NSD stellar population to be characterised with unprece

Context. Among the thousands of exoplanets discovered to date, approximately a few hundred gas giants on short-period orbits are classified as 'lonely'and only a few are in a multi-planet system with a smaller companion on a close orbit. The processes that formed multi-planet systems hosting gas giants on close orbits are poorly understood, and only a few examples of this kind of system have been

Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypox

A measurement of time-dependent CP violation in D0→π+π-π0 decays using a pp collision data sample collected by the LHCb experiment in 2012 and from 2015 to 2018, corresponding to an integrated luminosity of 7.7 fb-1, is presented. The initial flavor of each D0 candidate is determined from the charge of the pion produced in the D∗(2010)+→D0π+ decay. The decay D0→K-π+π0 is used as a control channel

Delivery care in Sweden is very safe, the incidence of maternal death is 5/100 000 and perinatal death

Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects a

Context. Stars and planets form in regions of enhanced stellar density, subjecting protoplanetary discs to gravitational perturbations from neighbouring stars. Observations in the Taurus star-forming region have uncovered evidence of at least three recent, star-disc encounters that have truncated discs (HV/DO Tau, RW Aurigae, and UX Tau), raising questions about the frequency of such events. Aims.

The band offsets of semiconductor heterojunctions are critical parameters for the design of electronic and optoelectronic devices. In this work, we report the fabrication of a Co3O4/3C-SiC p-n heterojunction and the determination of the conduction band and valence band offsets at the Co3O4/3C-SiC heterojunction. Our results reveal that the Co3O4/3C-SiC p-n heterojunction exhibits a type-II band al

INTRODUCTION: Assessing the potential sources of bias and variability of the Centiloid (CL) scale is fundamental for its appropriate clinical application. METHODS: We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts. Thirty-two CL pipelines were created using different combinations of referenc

This qualitative study aimed to increase the knowledge about Swedish school-based speech-language pathologists’ (SLPs) perception of language assessment tools and p ­ractices. Topics included purposes of language assessments within a school context, experience of the existing tools and important dimensions. Nineteen school-based SLPs were interviewed in focus groups and the data were analysed usinThis qualitative study was aimed at increasing the knowledge about Swedish school based SLPs’ perception of language assessment tools and practices. Purposes of language assessments within a school context, experience of existing tools and an assessment’s optimal content was targeted. 19 school based SLPs were interviewed in focus groups and the data were analyzed using qualitative content analysi

Balcinrenone (AZD9977) is a selective mineralocorticoid receptor modulator in development in combination with dapagliflozin for treatment of heart failure with impaired kidney function and chronic kidney disease. A prespecified concentration–QT analysis was performed based on data from a phase I single ascending dose study prospectively designed as a thorough QT study substitute. Oral single doses

In x-ray photoelectron spectroscopy (XPS), identifying the origin of peaks in the spectrum can be guided by theory calculations. With density functional theory (DFT), using pseudopotentials, one can obtain the difference in photoelectron energy for electrons originating from atoms of different environments, for example surface and bulk atoms, and thus model the surface core level shift (SCLS) ener

In this episode we talk to Georgia De Leeuw about her research on mining, green steel and the comfort alignment with extractivism in in the Swedish north, or indigenous Sápmi. Her PhD dissertation deals with Swedish extractivism in Sápmi through the examples of a planned iron ore mine in Gállok/Kallak and the hydrogen-based steel transition. The main aim is to understand the trust that is placed i

Multidisciplinary team meetings (MDTs) are recommended for patients with esophageal cancer. Improved staging, timeliness to surgery and better adherence to guidelines have been attributed to MDTs, but there are few studies published on the MDTs' effect on survival. All patients with esophageal cancer in Sweden between 2006 and 2018 were grouped according to whether they had been discussed at an MD

The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard Operational Procedure of the ESO and according to the GRADE methodology. Although BAO accounts for only 1–2% of all strokes, it has very poor natural outcome. W