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The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood. We hypothesized that expressions of IIR genes are controlled by the ROS-generated epigenetic-like mark 7,8-dihydro-8-oxo(d)gu

Primary mitochondrial diseases are a heterogeneous group of rare genetic disorders affecting approximately 125 persons per million. Mutations underlying these diseases give rise to biological changes (including decrease in cellular energy production and increase in reactive oxygen species), leading to organ failure, and commonly early morbidity. Mitochondrial diseases often present in early childh

BACKGROUND: To outline how the training program and work situation of residents in Obstetrics and Gynecology (OB-GYN) was affected by the pandemic and to illuminate how residents experienced these changes.METHODS: As part of the COVID-19 in Pregnancy and Early Childhood Staff (COPE Staff) cohort study, between January and May 2021, all participating residents were invited to answer a 28-question o

Conventional dendritic cells (cDCs) consist of two major functionally and phenotypically distinct subsets, cDC1 and cDC2, whose development is dependent on distinct sets of transcription factors. Interferon regulatory factor 8 (IRF8) is required at multiple stages of cDC1 development, but its role in committed cDC1 remains unclear. Here, we used Xcr1-cre to delete Irf8 in committed cDC1 and demons

Safety climate refers to the perceived value an organization places on safety at a specific point in time. To determine key predictors of safety climate in the fire service, we distributed a questionnaire to 105 career firefighters in a Swedish city of approximately 110,000 and analyzed their responses. We used these data to investigate the role of individual, work-group, and organizational factor

BACKGROUND: An intact umbilical cord allows the physiological transfusion of blood from the placenta to the neonate, which reduces infant iron deficiency and is associated with improved development during early childhood. The implementation of delayed cord clamping practice varies depending on mode of delivery, as well as gestational age and neonatal compromise. Emerging evidence shows that infant

ClimApp was developed to assist individuals in reducing the risk of exposure to thermal stress and to supply the user with individualized advice and recommendations. The tool integrates several human thermal models and heat indices with the local weather forecast and goes on to provide users with a prediction of their thermal stress based on their activity level, clothing level, and heat acclimati

Designing more efficient high-pressure homogenizers (HPHs) is important from an industrial perspective (reduce energy cost). Understanding the relationship between valve geometry and breakup is interesting from an emulsification research perspective. Typically, two different design principles are used for commercial HPHs: the traditional outward radial flow design and the newer inward radial flow

High-fat diets are associated with neuronal and memory dysfunction. Berries may be useful in improving age-related memory deficits in humans, as well as in mice receiving high-fat diets. Emerging research has also demonstrated that brain health and cognitive function may be related to the dynamic changes in the gut microbiota. In this study, the impact of Nordic berries on the brain and the gut mi

Background: Although mechanical ventilation is often lifesaving, it can also cause injury to the lungs. The lung injury is caused by not only high pressure and mechanical forces but also by inflammatory processes that are not fully understood. Heparin-binding protein (HBP), released by activated granulocytes, has been indicated as a possible mediator of increased vascular permeability in the lung

Hip fractures following a low-impact fall are common in the elderly. Finite element (FE) models of the proximal femur can improve the prediction of fracture risk over current clinical standards. Foramina in the femoral neck may influence its fracture mechanics, albeit the majority of FE modelling approaches do not consider them. This study aimed to show how foramina affect fracture propagation and

The built environment is important to achieve a sustainable society. From a sustainability perspective, refurbishment can be preferable to building anew. A significant proportion of the built environment needs to be refurbished. Refurbishment projects also provide the opportunity to proactively upgrade the working environment for users during operation and use.Research concerning the working envir

The multi-armed bandit (MAB) problem models a decision-maker that optimizes its actions based on current and acquired new knowledge to maximize its reward. This type of online decision is prominent in many procedures of Brain-Computer Interfaces (BCIs) and MAB has previously been used to investigate, e.g., what mental commands to use to optimize BCI performance. However, MAB optimization in the co

The purpose of this research was to explore the realization of the pro-environmental initiative in the Faroe Islands in which tourists were involved as volunteers. The research was aimed at understanding how this influences tourists’ perceptions of a destination. We were interested in filling the research gap regarding the importance of tourists’ direct involvement in pro-environmental initiatives

This chapter explores the desk as a material object as well as its sym- bolic representations in social work from a professional perspective. As we will demonstrate, different and sometimes incompatible meanings and functions associated with the desk reflect current tensions and profession- al dilemmas: On the one hand, ever since the emergence of the social work profession, the desk has symbolize