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The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). While APOE4 is strongly associated with amyloid-beta (Aβ), its relationship with tau accumulation is less understood. Studies evaluating the role of APOE4 on tau accumulation showed conflicting results, particularly regarding the independence of these associations from Aβ load. In this study, we examined t

This chapter revisits Iver Neumann’s seminal book The Uses of the Other (1999) in order to unpack its assumptions about collective identity formation in world politics. After having situated this work in its contemporary context and pointed to its significance, the chapter tries to demonstrate the extent to which its basic assumptions about collective identity formation replicates those that went

Contact nursing services have been implemented in Swedish cancer care to increase healthcare quality. Too little is known about the content and quality of these services and the organizational prerequisites provided to contact nurses. The aim of this study was to explore contact nurses’ perceptions of their services and organizational prerequisites, as well as the connection between organizational

Introduction: Little is known regarding the comparison of cardiovascular and kidney outcomes between lupus nephritis (LN) and other etiologies of chronic kidney disease (CKD). Methods: Using data from the Swedish Renal Registry (2006–2021), we compared long-term outcomes between patients with LN-CKD and patients with CKD due to primary glomerular diseases (PGD) and other CKD causes (Other-CKD, mai

A glimpse into a better world: The 4th Symphony Concert C with the world-class trumpeter Håkan Hardenberger and Jörg Widmann, the principal guest conductor of the NDR Radio Philharmonic, is about nothing less.While the warlike tones in Felix Mendelssohn Bartholdy's "Scottish" symphony finally give way to a roaring hymn of joy, Jörg Widmann's "Towards Paradise" strives for a utopian state of limbo.

BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie

Biopharmaceuticals, of which monoclonal antibodies are a mainstay, have revolutionized healthcare by enabling treatments with high precision and efficacy. However, their established manufacturing processes, particularly the downstream process, are complex, resource-intensive, and expensive, limiting global access to these drugs. This thesis examines how a more efficient, sustainable, and thus less

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail

Telomere length (TL) is a biomarker linked to age-related diseases based on its sensitivity to oxidative DNA damage and inflammation. Methylmercury (MeHg) is a common pollutant in fish. It may induce oxidative stress leading to shorter TL. However, previous research showed contradictory results and dose-concentration dependencies and non-linear relationships have been suggested. This study was car

Public sector organizations increasingly use digital platforms to foster value co-creation among diverse stakeholders and to address complex societal challenges, such as those related to sustainable development. Different kinds of digital platforms have been recognized as potential drivers of the societal transition toward a circular economy. However, little is known about the organization, govern

Background: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing. Objective: We assessed the impact of COVID-19 on patients with IEI. Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospita

The clarinetist, composer, and conductor Jörg Widmann is one of the shining lights of contemporary music. His credo is to combine tradition with new developments, resulting in timbres whose virtuosity, intensity, and directness both surprise and oftentimes confront the listeners, but also challenge them with quiet, fragile moments. The transparent, ethereal orchestral piece Armonica seems to defy

Real Filharmonía de Galicia participated in the Hércules Brass Festival in Celanova under the direction of Sebastian Zinca, with Hakan Hardenberger as soloist.Pieces included:Johann Georg Albrechtsberger: Concertino für Trompete, Streicher undB.c. in Es-DurM. v. Martinez: Sinfonía en Do M: 2.2.0.0 - 2.2Joseph Haydn: Konzert für Trompete und Orchester Es-Dur Hob. VIIe:1 Edvard Grieg: Zwei elegische

Self-injury is associated with significant psychological distress and functional impairments, including difficulties with self-care. However, little is known about how individuals engaging in self-injury perceive and manage self-care in their daily lives. This study aimed to explore the lived experiences of self-care among individuals receiving psychiatric treatment for self-injury and to identify

Despite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: PapDespite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: Pap