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Widespread implementation of cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) in clinical settings requires improved accuracy for diagnosis of prodromal disease and for distinguishing AD from non-AD dementias. Novel and promising CSF biomarkers include neurogranin, a marker of synaptic degeneration, and YKL-40, a marker of neuroinflammation.
In this paper, a novel method for analysing a bird’s song is presented. The song of male great reed warblers is used for developing and testing the methods. A robust method for detecting syllables is proposed and a classification of those syllables as compared to reference syllables is done. The extraction of classification features are based on the use of singular vectors in different time-freque
This thesis covers different topics related to the application of pseudospectral optimization methods in the field of automatic control. Pseudospectral optimization methods solve dynamic optimization problems by discretizing the state-space, creating a discretized version of a continuous problem. The resulting discretized optimization problems are solved by standard software for nonlinear optimiza
Background In mild asthma exercise-induced bronchoconstriction (EIB) is usually treated with inhaled short-acting beta(2) agonists (SABAs) on demand. Objective The hypothesis was that a combination of budesonide and formoterol on demand diminishes EIB equally to regular inhalation of budesonide and is more effective than terbutaline inhaled on demand. Methods Sixty-six patients with asthma (>12 ye
Aims. Observational studies of the Milky Way bulge are providing increasing evidence of its complex chemo-dynamical patterns and morphology. Our intent is to use the iDR1 Gaia-ESO Survey (GES) data set to provide new constraints on the metallicity and kinematic trends of the Galactic bulge, exploring the viability of the currently proposed formation scenarios. Methods. We analyzed the stellar para
Popular Abstract in Swedish Hur går det egentligen till när beslut fattas om nya, och för skattebetalarna kostsamma, väg- och järnvägsinvesteringar? Fattas besluten på basis av objektiva utredningar och noggranna kalkyler, eller är de ett resultat av politiska förhandlingar och spel mellan olika intressen? I denna avhandling undersöks investeringsplanering som politisk beslutsprocess dels genom enInvestment planning is a decision-making process with specific characteristics. It is often seen as a rational quest for solutions that are in the public interest, and the dominant discourse tends to be technical and economic. Public documents reproduce this picture of a decision-making process based on rationalist premises where analytical methods and objective facts form the basis for decisions.
Background: Dietary fibre is fermented by the colonic microbiota to carboxylic acids (CA), with potential health effects associated in particular with butyric and propionic acid. Objective: To investigate the formation of CA in the hindgut of healthy rats fed dietary fibre from different fractions of wheat shorts, a by-product of the milling of wheat. Design: Rats were fed dietary fibre (80 g/kg f
Enterohemorrhagic Escherichia coli (EHEC) is a highly virulent pathogen that can cause diarrhea and a life-threatening disease known as hemolytic uremic syndrome. EHEC possess an array of virulence factors that can exert severe consequences in the host. Shiga toxin constitutes a key virulence factor. Enteropathogenic Escherichia coli (EPEC) is a leading cause of infant diarrhea. EHEC and EPEC are
In this paper, we introduce a time-frequency spectral estimator for smooth spectra, allowing for irregularly sampled measurements. A non-parametric representation of the time dependent (TD) covariance matrix is formed by assuming that the spectrum is piecewise linear. Using this representation, the time-frequency spectrum is then estimated by solving a convex covariance fitting problem, which also
ASHEIM B. The changing role of learning regions in the globalizing knowledge economy: a theoretical re-examination, Regional Studies. Highlighting four theoretical developments, this paper theoretically re-examines the learning region in view of the changing roles of regions in the globalizing knowledge economy: (1) from specific contexts to general regional development strategies; (2) introducing
Objective. The study was designed as a prospective non-interventional, observational study to elucidate the potential value of fetal middle cerebral artery Doppler velocimetry to identify brain-sparing flow in a surveillance program for suspected intrauterine growth restriction (IUGR). Material and methods. The study was carried out at Skåne University Hospital, Malmö, Sweden. One hundred and twen
The Autism-Tics, AD/HD, and other Comorbidities (A-TAC) inventory is used in epidemiological research to assess neurodevelopmental problems and coexisting conditions. Although the A-TAC has been applied in various populations, data on retest reliability are limited. The objective of the present study was to present additional reliability data. The A-TAC was administered by lay assessors and was co
Objective. To investigate the type of urinary diversion performed after cystectomy in patients with muscle-invasive bladder cancer in Sweden, using data from a population-based national register. Material and methods. Since 1997, the Swedish Bladder Cancer Register has included more than 90% of all patients with newly diagnosed bladder cancer. The different types of urinary diversion performed in
Despite almost 100 years of research, the fundamentals of fire spalling of concrete are not yet fully understood. Many different theories exist, each trying to describe the coupling between different phenomenon leading to fire spalling. Some of these phenomenon have been investigated and are presented in this thesis. The thermal properties at high temperature have been investigated using the Trans
The European Medicines Agency does not recommend the use of hydroxyethyl starch-based volume replacement solutions in critically ill patients due to an increased risk of renal failure. However, this recommendation is questionable for its perioperative use. Several recent randomised controlled studies do not indicate a risk for renal failure-not even after high-risk surgery. Human albumin is used i
Objective : To determine the association between health-risk behaviors and a history of sexual coercion among urban Chinese high school students. Design : A cross-sectional study was performed among 109,754 high school students who participated in the 2005 Chinese Youth Risk Behavior Survey. Data were analyzed for 5,215 students who had experienced sexual intercourse (1,483 girls, 3,732 boys). Mul
Background: Studying contemporary hybridization increases our understanding of introgression, adaptation and, ultimately, speciation. The sister species Ischnura elegans and I. graellsii (Odonata: Coenagrionidae) are ecologically, morphologically and genetically similar and hybridize. Recently, I. elegans has colonized northern Spain, creating a broad sympatric region with I. graellsii. Here, we r
The spectroscopy and structure of excited states of N similar to Z nuclei in the mass 70-100 region has been investigated using two techniques. In the A similar to 70-80 region fusion evaporation reactions coupled with the recoil-beta-tagging method have been employed at Jyvaskyla to study low-lying states in odd-odd N = Z nuclei. Results from these and other data for known odd-odd nuclei above ma
