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Syftet med avhandlingen var att undersöka och utvärdera bindningen av molekyler mot ett målprotein som är involverad i tillväxten av cancerceller. Undersökning genomfördes på Red Glead Discovery med WAC (weak affinity chromotography) som är en kromatografisk separationsmetod, där molekyler med olika vikt pumpas genom olika kolonner och retentionstiden för molekylerna i kolonnen detekteras. MolekylThe drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been impleme

The aim of this master thesis is to examine how institutional rules and demands, present in cultural politics, affects the work with digitalisation in local museums. According to narrative trends in Sweden’s national cultural politics, digitalisation has the potential to encourage and increase democracy by enabling participation and wider access. Therefore, digitisation practices in cultural insti

This thesis aims to deconstruct the manner in which cultural differences are perceived and dealt with in international and multicultural school in Sweden by combining postcolonial and poststructuralist theories. Applying Bhabha’s theoretical turn from cultural diversity to cultural differences, ethnographic methods were used to examine parents’ and staff member’s relationship with these difference

The goal of this thesis is to construct p-harmonic functions on the Lie groups U(n), SU(n), U(p,q) and SU(p,q) equipped with the semi-Riemannian metric g(Z,W) = Re trace ( Z W^t ). To do this we present a method which relies on the notion of eigenfunctions. We define these functions and find examples of them defined on the relevant groups. To our knowledge, these eigenfunctions have not been p

The Defunctionalization of carbonyl functionality into methylene by metal-catalyzed hydrosilylation is very important in organic synthesis. But very less work is done in literature because of the need for a large amount of energy for C-O bond dissociation. Metal-catalyzed defunctionalization of carbonyl compounds in the presence of silanes as a mild reducing agent is studied because of its presenc

Befolkningen i Sverige står inför en demografisk utveckling och en allt större andel av Sveriges befolkning kommer vara äldre. År 2018 estimerades att andelen personer äldre än 80 år kommer öka med upp till hela 50 procent i Sverige under de närmaste tio åren Det leder i sin tur till en större påfrestning på landets vård och omsorg och det kommer behövas fler äldreboenden för att möta den ökande eThe Swedish population is facing a demographic development that will result in a larger proportion of the population being older than it is today. This will lead to a greater strain on the country’s health- and elderly care systems. In 2018, it was estimated that the proportion of people older than 80 years will increase by as much as 50 % in Sweden over the next ten years. With an increased numbe

Syftet med den aktuella studien var att, med kvalitativ och explorativ ansats, undersöka förutsättningarna för föräldrar till barn med autismspektrumtillstånd (AST) att skapa trygg anknytning för sina barn, utifrån en förståelse för deras tankar och känslor om sin relation med sitt barn, och sitt föräldraskap – så kallade omvårdnadsrepresentationer. Vidare syftade studien till att undersöka huruvi

Förpackningar är viktigare än vad man kan tro! De skyddar den värdefulla produkten från oönskade bakterier som kan göra att den blir dålig. För att drycken ska hålla längre så måste förpackningen behandlas för att ta bort allt som kanske kan skada personen som dricker innehållet. Man ser också till att bakterier utanför förpackningen inte kan ta sig in. Detta innebär att förpackningen är aseptisk.Sealing of the transverse seal (TS) represents a fundamental step in the assembling of aseptic packages. To prevent the package from being penetrated by gases and pathogens the TS must be tightly sealed. An understanding of the conditions that influence the flow and deformation of polymers is instrumental to designing sealing systems that are reliable and effective. This thesis was focused on cons

This research explains the distribution of rewards within the innovative economic practice of online motorcycle taxi services in Indonesia. Those analyzed are online transportation platforms and their driver-partners. These two are analyzed using the theoretical framework of the innovation economy, which is conceptualized as cumulative, uncertain, and collective economic processes by Mariana Mazzu

This essay focuses on the phenomenon of the new man and new masculinity and how it is used and described in fashion articles. The phenomenon points at something new but within a historical context we see that the new man goes back in history. The aim of this essay is to find what the new man and its new masculinity is today according to fashion journalism. The empirical data consists of ten fashio

Syftet med den här studien har varit att tolka hur unga män i åldern 18–24 år utifrån emotionssociologisk synvinkel upplever känslan av rädsla och trygghet, och hur de utifrån ett genusperspektiv talar om känslor. Vidare har studien undersökt vad som bidrar till de unga männens känsla av rädsla och trygghet. Detta har gjorts genom en kvalitativ metod i form av fem semi strukturerade intervjuer med

Abstract The utilization of one-carbon compounds, such as methanol, as a feedstock for production of high value compounds is a fast developing area within cell factory engineering. Methanol is a cheap and easily stored compound, which can be produced from CO2 and renewable energy. Engineering microbial cell factories for utilization of methanol could therefore contribute to decreasing the amounts

Society and companies are becoming increasingly digitized. If you compare company structures historically and today you will see some palpable differences. Today, there are companies that work almost exclusively digitally. Therefore, a new focus is created on assets that lack physical form, that is intangible assets. These are dealt with today within the accounting regulations and practices, but t

n this master’s thesis, one studies the liquidity of bonds. One considers bid-ask spread and develops four estimators of this liquidity measure based on trading data. One also computes Amihud’s measure. This approach helps to determine liquidity and its associ-ated costs without quotation. One finds out that the Roll, the FHT estimators and the Amihud measure take the lead. One looks at the changes

The aim of this thesis is to describe and explain how meal-box, as a digital device designed to assist households in carrying out eating practices, reconfigure household practices and enable specific behavioural activities, including sustainability. Taking a socio-material and practice theory approach and drawing on an ethnographic study of three meal-box providers – The Seasons, Hello Fresh and L

Studier har visat att det kan göras bra bedömningar av trafiksäkerhetstillstånd och dess bidragande faktorer genom att studera konflikterna i trafiken istället för olyckorna. Genom att undersöka hur konflikterna i en trafikplats ser ut kan man få mer data och få den mycket snabbare än om man undersöker olycksdata. Genom att använda nya verktyg till datorer som djupinlärning kan man även lättare taStudies have shown that good assessments can be made of traffic safety conditions and contributing factors by studying the conflicts in traffic rather than the accidents. By analysing the conflicts in a location with traffic you can get more data and in a shorter time-frame than if analysing accident data. By using new tools for computers such as deep learning, it's easier to get these conflic

The aim of this thesis is to describe and explain how meal-box, as a digital device designed to assist households in carrying out eating practices, reconfigure household practices and enable specific behavioural activities, including sustainability. Taking a socio-material and practice theory approach and drawing on an ethnographic study of three meal-box providers – The Seasons, Hello Fresh and L

As one of the most important sites in which and through which discourse is articulated and disseminated, newspapers play particularly extensive roles in furthering understandings of human rights cases involving citizens of dual nationality and foreign policy. Drawing on critical discourse analysis and the practice of journalistic framing, this study examined the effects of intertextuality on the d

The modernization of China comes as one of the most interesting topics not only at this moment but also has been researched for a long time. The individualization theories come as a result of modernity. This thesis draws on ten in-depth interviews in order to analyze the individualization among the educated, middle-class young people who were born in the 1990s by testing Yan Yunxiang’s theories of

Climate change, along with grassland degradation, have become major causes of livelihood difficulties for herdsmen in Inner Mongolia for the past few decades. The purpose of this study is to seek better understanding of the relationships between climate change and herders’ livelihoods in pastoral communities in Inner Mongolia, map out the major institutional changes on climate adaptation measures