Sökresultat

Filtyp

Din sökning på "*" gav 529942 sökträffar

Ovarian cancer surgery - A population-based registry study

Background/Aim: To evaluate ovarian cancer surgery in tertiary centers (TC) and regional hospitals (RH). Patients and Methods: Data from the GynOp registry on patients undergoing surgery for ovarian cancer or borderline tumor from 2013 to 2015 were analyzed. Results: Four TC and 21 RH reported 1, 108 cases of surgery with curative intent, 770 cases (69.5%) in TC and 338 cases (30.5%) in RH. Out of

Eastern Mediterranean Mobility in the Bronze and Early Iron Ages : Inferences from Ancient DNA of Pigs and Cattle

The Late Bronze of the Eastern Mediterranean (1550-1150 BCE) was a period of strong commercial relations and great prosperity, which ended in collapse and migration of groups to the Levant. Here we aim at studying the translocation of cattle and pigs during this period. We sequenced the first ancient mitochondrial and Y chromosome DNA of cattle from Greece and Israel and compared the results with

Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children

The aim of the study was to assess possible relationships between adipocyte fatty acid-binding protein (FABP4) and total body fat (TBF), abdominal fat, body fat distribution, aerobic fitness, blood pressure, cardiac dimensions and the increase in body fat over 2 years in a community sample of children. A cross-sectional study was used in a community sample of 170 (92 boys and 78 girls) children ag

Fetal hyperglycemia changes human preadipocyte function in adult life

Context: Offspring of women with gestational diabetes (O-GDM) or type 1 diabetes mellitus (O-T1DM) have been exposed to hyperglycemia in utero and have an increased risk of developing metabolic disease in adulthood. Design: In total, we recruited 206 adult offspring comprising the two fetal hyperglycemic groups, O-GDM and O-T1DM, and, as a control group, offspring from the background population (O

Associations between prediagnostic blood glucose levels, diabetes, and glioma

Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269

Nuclear Structure Studies near 208Pb and γ-ray Imaging Techniques

AGATA är en speciell positionskänslig detektor för gammastrålning. Genom attanvända en sådan detektor är det möjligt att rekonstruera den väg som gam-mastrålningen tar genom detektorn. Det garanterar en mycket högre känslighetför detektion av gamma strålning än vad var möjlig för tidigare typer av de-tektorer. Detta betyder att vi kan få tillgång till mycket mer information omatomkärnan än vad vi This thesis focuses on a high-resolution γ-ray spectroscopy experiment where the fragmenta- tion of a 208 Pb primary beam was used to populate even-mass nuclei around 208 Pb. It was conducted in 2012 using the Advanced GAmma-ray Tracking Array (AGATA) while it was placed at GSI Darmstadt, Germany. Projectile-like fragments were selected and identified with the GSI Fragment Separator. The final aim

Zero-group velocity modes in plates with continuous material variation through the thickness

Lamb modes with zero group velocity at nonzero wave numbers correspond to local and stationary resonances in isotropic plates. Lamb modes can be utilized for nondestructive evaluation of the elastic properties and thickness. One example of an application is the testing of plate-like concrete structures. In this example, continuous variation in the material velocity through the thickness may occur.

3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy : A pilot study

Structural analysis of biological membranes is important for understanding cell and subcellular organelle function as well as their interaction with the surrounding environment. Imaging of whole cells in three dimension at high spatial resolution remains a significant challenge, particularly for thick cells. Cryo-transmission soft X-ray microscopy (cryo-TXM) has recently gained popularity to image

Epigenetic modifications and gestational diabetes : A Systematic review of published literature

Objective: To summarize the current knowledge on epigenetic alterations in mother and offspring subjected to gestational diabetes (GDM) and indicate future topics for research. Design: Systematic review. Methods: We performed extensive searches in PubMed, EMBASE and Google scholar, using a combination of the search terms: GDM, gestational diabetes, epigenetic(s), methylation, histone modification,

The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders : a delineation of four potential pathways to illness

How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major p

Exploring dementia management attitudes in primary care : a key informant survey to primary care physicians in 25 European countries

Background:: Strategies for the involvement of primary care in the management of patients with presumed or diagnosed dementia are heterogeneous across Europe. We wanted to explore attitudes of primary care physicians (PCPs) when managing dementia: (i) the most popular cognitive tests, (ii) who had the right to initiate or continue cholinesterase inhibitor or memantine treatment, and (iii) the rela

Attitudes to Stem Cell Therapy among Ischemic Stroke Survivors in the Lund Stroke Recovery Study

Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among stroke patients potentially suitable for SCT. Consecutive fir

Glucose homeostasis, beta cell function, and insulin resistance in relation to vitamin D status after gestational diabetes mellitus

Introduction: We wanted to determine vitamin D status after gestational diabetes mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D3 (25OHD3) are associated with beta cell function, insulin resistance or a diagnosis of diabetes after GDM. Material and methods: Glucose homeostasis was assessed during a 75-g oral glucose tolerance test one to two years after delivery in 376 women w

Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment

BackgroundThe role of inflammation in Alzheimer’s disease (AD) and other cognitive disorders is unclear. In a well-defined mono-center population, we measured cytokines and chemokines in paired serum and cerebrospinal fluid (CSF) samples. MethodsConsecutive patients with AD (n = 30), stable mild cognitive impairment (SMCI, n = 11), other dementias (n = 11), and healthy controls (n = 18) were inclu

Postgrowth and Wellbeing : Challenges to Sustainable Welfare

This book presents a detailed and critical discussion about how human wellbeing can be maintained and improved in a postgrowth era. It highlights the close links between economic growth, market capitalism, and the welfare state demonstrating that, in many ways, wellbeing outcomes currently depend on the growth paradigm. Here the authors argue that notions of basic human needs deserve greater empha

Optically Stimulated Luminescence for Retrospective Radiation Dosimetry. The Use of Materials Close to Man in Emergency Situations

If an accident or attack involving radiological or nuclear material were to happen, people from the general public would be at risk of exposure to ionising radiation. Unlike people working with ionising radiation, for whom level of exposure to radiation is constantly monitored with dosemeters, people from the general population do not wear dosemeters; thus, the dose estimations for these individua