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Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen
This paper is a translation of my "Preference Utilitarianism by Way of Preference Change?", in which I revisit Richard Hare’s classical and much discussed argument for preference utilitarianism (Moral Thinking, 1981), which relies on the conception of moral deliberation as a process of thought experimentation, with concomitant preference change. The paper focuses on an apparent gap in Hare’s reaso
The subject of the thesis is the psychê, a Greek word whose closest equivalent is the Swedish “själ”, the English “soul”, the French “âme” and the German “Seele”. The meanings of these words are far from being the same. What is more, the Greek psychê has shifting meanings, both synchronically and diachronically speaking. We are faced with two problems: What does the word psychê designate and how i
Background: Hitherto, risk prediction models for preoperative ultrasound-based diagnosis of ovarian tumors were dichotomous (benign versus malignant). We develop and validate polytomous models (models that predict more than two events) to diagnose ovarian tumors as benign, borderline, primary invasive or metastatic invasive. The main focus is on how different types of models perform and compare. M
Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however, there are little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intrahepatic bile duct (IBD), and gallbladder and biliary tract cancers outside of the l
Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a
Context: The questions of how many individuals and how much time to use for a single testing task are critical in software verification and validation. In software review and usability evaluation contexts, positive effects of using multiple individuals for a task have been found, but software testing has not been studied from this viewpoint. Objective: We study how adding individuals and imposing
Using conceptual dimensions identified by the literature on political leadership, this article compares its transformations at the local level in Europe. Often associated with the alleged shift to governance, the strengthening of the executive comes forward as the underlying tendency in contemporary local leadership. Empowered individualised leadership emerges, in terms of coming to and taking off
We present results of a search for two hypothetical strange dibaryon states, i.e. the H-dibaryon and the possible (Lambda n) over bar bound state. The search is performed with the ALICE detector in central (0-10%) Pb-Pb collisions at root S-NN = 2.76 TeV, by invariant mass analysis in the decay modes (Lambda n) over bar (d) over bar pi(+) and H-dibaryon -> Lambda p pi(-). No evidence for these bou
We present an angle-resolved photoemission study of the valence band of Au/(root 3 x root 3-) - R30 degrees-4H-SiC(0 0 0 1). Several different two-dimensional states could be identified, depending on the Au coverage and annealing temperature. In the case of silicide at the surface, two-dimensional Shockley-like state is observed for higher coverages, but a potential interface state is observed at
Background: Health care policies in many countries aim to enable people with dementia to live in their own homes as long as possible. However, at some point during the disease the needs of a significant number of people with dementia cannot be appropriately met at home and institutional care is required. Evidence as to best practice strategies enabling people with dementia to live at home as long
The tubular cells of the adult kidney are normally mitotically quiescent, in stark contrast to the massive regenerative capacity of the injured renal epithelium. In Paper I we characterized a new cell population of progenitor cells using ALDH as a selection marker. These cells are situated in the proximal tubular epithelium and are called proximal tubular progenitor cells (PTPCs). Gene expression
Associations between various malignancies and work in the pulp and paper industry have been reported but mostly in analyses of mortality rather than incidence. We aimed to study cancer incidence by main mill pulping process, department and gender in a Swedish cohort of pulp and paper mill workers. The cohort (18,113 males and 2,292 females, enrolled from 1939 to 1999 with > 1 year of employment) w
Background: Nocturia, a common complaint in aging men and women, is frequently cited as the cause of nocturnal awakenings leading to sleep loss, daytime fatigue, and reduced quality of life (QOL). Objective: Investigate the association of nocturia with QOL and depressive symptoms among men and women. Design, setting, and participants: A population-based epidemiologic survey of urologic symptoms am
