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Psychotropic drugs and falling accidents among the elderly: a nested case control study in the whole population of Scania, Sweden.

STUDY OBJECTIVE: The objective of this study was to investigate the associations between medication with psychotropic drugs and falling accidents in the whole population aged 65 years and older in the county of Scania, Sweden. DESIGN: A population based nested case control study was performed. SUBJECTS: Cases were persons registered in the Region Healthcare database after a falling accident during

Risk factors for depressive disorders in the Lundby cohort - A 50 year prospective clinical follow-up.

BACKGROUND: Depressive disorders are common and disabling. The Lundby Study is a prospective study of a community sample that started in 1947(N=2550). In 1957, 1013 newcomers were added. The latest field investigation was carried out in 1997. AIM: To identify risk factors for depressive disorders. METHOD: The Lundby database contains clinical assessments of the subjects made by psychiatrists. It a

Familial risk factors shared by venous thromboembolism and cancer: A nationwide epidemiological study of Swedish families.

BACKGROUND: Cancer and venous thromboembolism (VTE) are associated disorders. In the present nationwide study, we analyzed the risk of cancer in siblings, offspring and spouses of individuals hospitalized for VTE (and vice versa) with the aim of identifying shared familial risk factors for cancer and VTE. MATERIAL AND METHODS: The Multigeneration Register was linked to the Swedish Hospital Dischar

Incidence of cancer of unknown primary in Sweden: analysis by location of metastasis.

Increasing incidences of cancer of unknown primary (CUP) have been observed in Sweden previously. However, it is not known how the incidence trends for specific locations of metastasis vary. Site-specific data are available on the basis of the ninth international classification of diseases. CUP patients were identified between 1987 and 2008 from the Swedish Family-Cancer Database. Malignant neopla

Oncogenic flt3 receptors display different specificity and kinetics of autophosphorylation.

OBJECTIVE: Fms-like tyrosine kinase-3 (FLT3), a growth factor receptor normally expressed in hematopoietic progenitor cells, has been shown to have an important role in the development of acute myeloid leukemia due to activating mutations. FLT3 mutations are found in approximately one third of AML patients and correlate with a poor prognosis, thus making the FLT3 receptor a potential therapeutic t

Progressive multifocal leukoencephalopathy - the importance of early diagnosis illustrated in four cases.

Progressive multifocal leukoencephalopathy (PML) is a rare, deadly demyelinating disease of the central nervous system, which is caused by a reactivation of the DNA polyomavirus JC and occurs in immunosuppressed individuals. So far, only 25 cases have been described in patients with SLE and none survived without antiviral therapy and only two cases in RA. We present four additional cases from a de

Comparison of measurements of autoantibodies to glutamic acid decarboxylase and islet antigen-2 in whole blood eluates from dried blood spots using the RSR-enzyme linked immunosorbent assay kits and in-house radioimmunoassays.

To evaluate the performance of dried blood spots (DBSs) with subsequent analyses of glutamic acid decarboxylase (GADA) and islet antigen-2 (IA-2A) with the RSR-ELISAs, we selected 80 children newly diagnosed with type 1 diabetes and 120 healthy women. DBSs from patients and controls were used for RSR-ELISAs while patients samples were analysed also with in-house RIAs. The RSR-ELISA-GADA performed

Incretin hormone secretion over the day.

The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone se

Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays.

Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two severe autoimmune connective tissue diseases. The fundamental knowledge about their aetiology is limited and the conditions display complex pathogenesis, multifaceted presentations, and unpredictable courses. Despite significant efforts, the lack of fully validated biomarkers enabling diagnosis, classification, and monitoring

High-resolution genomic screening in mantle cell lymphoma--specific changes correlate with genomic complexity, the proliferation signature and survival.

Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) and numerous copy number aberrations (CNAs). Recently, gene expression profiling defined a proliferation gene expression signature in MCL where high scores predict shorter survival. We investigated 31 MCL cases using high-density single nucleotide polymorphism arrays and correlated CNA patterns with the proliferation signature an