Filtyp
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
International research collaboration stands at a pivotal juncture, shaped by enduring structural inequalities between high-, middle-, and low-income countries and challenged by a trend of withdrawal from international collaboration. These asymmetries can create a misalignment between global scientific progress and the capacity to address pressing societal crises, which often disproportionately aff
This paper presents a single-layer filtering antenna (filtenna) based on a compact square substrate-integrated waveguide (SIW) cavity for millimeter-wave (mmWave) applications. The cavity operates in the fundamental TE110 mode to enable beam scanning, while a central shorting via introduces the TE210 mode, broadening the bandwidth. A radiating slot, placed at high-intensity regions of both modes,
Background and aimImproving the quality of health care is a global priority, yet many conventional quality improvement approaches, rooted in industrial models of standardisation and control, struggle to account for the uncertainty and complexity of clinical care. Trauma, defined as external injury and the body's physiological response, causes about 4.4 million deaths each year. The impact is greatBackground and aimImproving the quality of health care is a global priority, yet many conventional quality improvement approaches, rooted in industrial models of standardisation and control, struggle to account for the uncertainty and complexity of clinical care. Trauma, defined as external injury and the body's physiological response, causes about 4.4 million deaths each year. The impact is great
Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o
Scope: Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus on the management and follow-up of VGEI, with a focus on antimicrobial strategies. Methods: A modified Delphi method was conducted to reach consensus on key aspects of VGEI care, including antim
Cu nanoparticles are widely used in different fields. Controlling the Cu oxidation state and the local strain is fundamental for optimizing its efficiency in processes, such as catalytic reactions. In this work, Cu nanoparticles were synthesized by using glucose as a reducing agent. Different synthesis conditions led to nanoparticles with a tunable local strain and Cu(0)/Cu 2O ratio. The amounts o
Insect wing interference is highly sensitive to the membrane thickness and has shown remarkable potential to differentiate insect species, both ex vivo in laboratory settings and for free-flying insects in situ. While several studies have reported diversity of wing interference patterns, no study has linked this resonant coherent scattering from membranes to the goniometric scattering phase functi
Intersectionality is increasingly being operationalized as part of gender mainstreaming efforts across national and multilateral contexts. One prominent example can be located in Sweden’s 2015 institutional commitment to centering future gender equality policy in an intersectional analysis. This article explores the complexities of institutionalizing intersectionality in Swedish gender equality po
The complexity of modern healthcare continues to evolve, emphasizing the need for comprehensive collaboration among professionals from diverse backgrounds, patients, and their families to integrate care. Multidisciplinary team meetings (MDTMs) have emerged as an opportunity to advance interprofessional collaborative practice. However, despite their growing prevalence in clinical and educational co
FN:s oberoende kommission har slagit fast att ett folkmord pågår i Gaza. Trots det vägrar Lunds universitetsledning att ompröva sina samarbeten med israeliska universitet och företag med kopplingar till vapenindustrin.Lunds universitet måste nu ta ansvar och avbryta dessa samarbeten – eller erkänna att man väljer att blunda för brott mot mänskligheten. Det skriver 16 forskare från Lunds universite
Glucuronidation is the major phase II biotransformation reaction that facilitates the clearance of exogenous compounds from the human body. Glucuronidated metabolites have been investigated in urine samples at a broad scale; however, their characterization in other human biospecimens is underexplored. Our study has now performed a comprehensive profiling of glucuronides in plasma, fecal, and cereb
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
We report the fabrication of three-dimensional topological insulator heterostructures using a single-step bottom-up approach based on directional solidification. These materials exhibit atomically smooth interfaces, preserving topological surface states and enabling hetero-junction formation. This scalable approach paves the way for advancements in spintronics, quantum computing, and novel optoele
Meta-analyses are vital for synthesizing evidence in medical research, but conflicts of interest can introduce research bias, undermining the reliability of the synthesized findings. This paper proposes a new robust Bayesian meta-analysis model. The model inflates uncertainty of low-quality studies and incorporates a bias term for studies subject to conflicts of interest. Using a random-effects mo
The Canary Islands are an island chain created by volcanic activity, despite extensive studies of the region there is not a clear consensus of their process of creation, primarily there is a question concerning the origin of the magmas which has built up this chain of islands. The largest contributor to these uncertainties is the continued volcanic activity on older islands, something which does n
Aims: Spontaneous coronary artery dissection (SCAD), causing acute coronary syndrome (ACS), primarily in middle-aged women, is diagnosed with invasive coronary angiography (ICA). Due to the risk of dissection propagation with ICA, a non-invasive diagnostic tool is needed. We investigated coronary computed tomography angiography (CCTA) findings in acute SCAD, as well as the inter-modality agreement
Al-Hoorie, Hiver, and In'nami (2024) offer compelling arguments for why L2 motivational self-system research is currently in a state of validation crisis. Seeking a constructive resolution to the crisis, in this response we argue that two fundamental conditions are needed for the field to emerge stronger: psychological readiness and methodological maturity. For psychological readiness, we call for
