Popular Abstract in Swedish En deletion innebär att det fattas en bit DNA i en kromosom. Deletioner kan variera i storlek från enstaka baspar till en stor del av en kromosom. Deletioner kan orsaka sjukdomar, men det finns också exempel på deletioner som inte ger någon påvisbar effekt på individen. Genom att analysera genetiska markörer i familjer kan man hitta mönster som kan förklaras av deletionA deletion is defined as a missing piece of a chromosome, ranging in size from as small as a single base pair to as much as an entire arm of a chromosome. Deletions can cause diseases, but may also have a neutral effect in the genome. In this thesis, I describe how inherited deletions can be detected by analysis of the segregation pattern of genetic markers in pedigrees. These methods are based on

Thermal stability of food-borne pathogens in apple cider is influenced by the composition of the product. As a preliminary step to determine the effect of pasteurization of apple cider on the survival of Escherichia coli O157:H7, a study was carried out to characterize apples and unpasteurized apple cider produced by a Guelph area orchard. Samples of commercial unpasteurized cider and the constitu

During the last decades the need to control the paper production process has grown, due to the technological development and the continuing increases in quality demands. Recent development of sensors and fast, high-capacity computers open up new possibilities for the development of high capacity monitoring systems for the paper industry. Optical methods have advantages for performing fast and high

The purpose of this thesis is to study how the Swedish working-class authors, and close friends, Eyvind Johnson (1900-1976) and Rudolf Värnlund (1900-1945) during the interwar period portray the individual and collectives of different kinds. The studied novels are Eyvind Johnson’s Timans och rättfärdigheten (1925; Timans and righteousness), Bobinack (1932), Romanen om Olof (1934-1937; The novel ab

It is well known that Catholic nuns and sisters played an important role in modern society, and that they in many ways paved the way for the entrance of women into professional life within the social sector. Modern research has also pointed out their social achievements as missionaries in the third word. But it is less known that female Catholic congregations also led school, hospitals and other s

Many scholars have claimed that the stone battle axes of the Battle Axe Culture were status objects with a social rather than a pratical function. One way of investigating this is to study the context in which the battle axes were manufactured, and by whom. If any object is to serve as a mark of status, it must be possible for someone who wishes to assert his/her superiority over other community m

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Popular Abstract in Swedish Pyrimidiner är DNA-byggstenar som är essentiella för cellens överlevnad och delning. I mänskliga celler finns pyrimidiner att tillgå antingen genom återupptag eller genom biosyntes (nysyntes). Biosyntesen av pyrimidiner sker i flera steg och i ett av dem spelar enzymet Dihydroorotat dehydrogenas (DHODH) en avgörande roll genom att katalysera en oxidationsreaktion. När cIn the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. Potent inhibitors were identified within three classe

Force feedback (FF) is a technology which is very interesting in the context of human machine interfaces. This as it is usable as a haptic interface, which makes it possible to model and simulate objects and textures. One problem with haptic FF devices today is that most of them are of professional or research standard, which makes them expensive. The technology of FF have also been introduced in