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Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. The thesis evaluates the effect of radiolabelling chemistry on biodistribution and targeting properties of Affibod
A critique of Felicitas Goodman's proposal of different states of consciousness for different postures.
The definition of complementary and alternative medicine has been much debated in recent years as this type of therapy has increasingly become a focus of public and academic attention. Individual authors typically stipulate a definition for purposes of their particular articles, and definitions have varied with the perspectives and affiliations of authors. The panel on definition and description o
Background: Continued blood flow in the aneurysm sac after repair, also known as endoleak, can occur after both open and endovascular popliteal aneurysm repair (EPAR) with risk for aneurysm sac enlargement. Primary aims were to investigate aneurysm sac growth and the presence and classification of endoleak after EPAR using contrast-enhanced ultrasound (CEUS).Methods: Cross-sectional study of patie
Molecular clocks estimate that diatom microalgae, one of Earth’s foremost primary producers, originated near the Triassic–Jurassic boundary (200 Ma), which is close in age to the earliest, generally accepted diatom fossils of the genus Pyxidicula. During an extensive search for Jurassic diatoms from twenty-five sites worldwide, three sites yielded microfossils initially recognized as diatoms. Afte
Experimental studies characterizing the reactivity of siliceous materials, such as biogenic silica from the field or laboratory cultures, typically require organic matter removal prior to experimental analysis. Consequently, it is highly desired to develop and optimize a cleaning protocol that imposes minimal alterations to the reactivity of the siliceous substrate and can be robustly employed amo
The polar region is experiencing one of the most rapid environmental changes driven by atmospheric warming, and feedbacks within the cryosphere. Under such a setting, it is crucial to understand the biogeochemical cycling of the nutrient silicon (Si) in the high latitudes, which is regulating the nutrient supply to polar ecosystems, and is linked to the global carbon cycle via diatom production. H
Continental-margin sediments account for ~ 50% of the oceanic biogenic silica burial despite covering < 10% of its area. In Mississippi Sound, a coastal lagoon in the northern Gulf of Mexico (nGoM), we measured sediment biogenic silica at sites removed from major freshwater discharge sources using the traditional method and a method that has been modified for deltaic systems to quantify other reac
Biogeochemical cycling in high-latitude regions has a disproportionate impact on global nutrient budgets. Here, we introduce a holistic, multi-disciplinary framework for elucidating the influence of glacial meltwaters, shelf currents, and biological production on biogeochemical cycling in high-latitude continental margins, with a focus on the silica cycle. Our findings highlight the impact of sign
Abstract Type 2 diabetes mellitus (T2DM) is a heterogeneous and a complex disease defined by hyperglycemia. Thepancreas and its islets are central for glucose homeostasis and healthy adipose tissue. In turn, lipid levels in the bloodare crucial for glucose level stability. Both genetic and environmental factors and their interaction play a pivotal role inthe risk and development of the disease. In
BackgroundLeft ventricular (LV) lead position may be an important factor for delivering effective cardiac resynchronization therapy (CRT). We therefore aimed to evaluate the effects of LV lead position, stratified by native QRS morphology, regarding the clinical outcome.MethodsA total of 1295 CRT-implanted patients were retrospectively evaluated. LV lead position was classified as lateral, anterio
The International Court of Justice has consistently required a stricter standard of proof for ‘charges of exceptional gravity’. The Bosnia Genocide and Croatia Genocide cases saw the Court require the high standard of ‘fully conclusive’ evidence across all elements of the allegations of genocide. Despite the difficulties associated with obtaining the necessary evidence of the intent of the perpetr
ObjectivesTo explore the utilization of three-dimensional (3D) endoanal ultrasound (EAUS) for the follow-up of the anal fistula plug (AFP), describe morphological findings in postoperative 3D EAUS, and evaluate if postoperative 3D EAUS combined with clinical symptoms can predict AFP failure.Materials and methodsA retrospective analysis of 3D EAUS examinations performed during a single-centre study
The Paris Agreement includes the goals of ‘holding the increase in the global average temperature to well below 2°C above pre-industriallevels’ and ‘making finance flows consistent with a pathway towards low greenhouse gas emissions’. Industrial energy efficiency will playan important role in meeting those goals as well as becoming a competitive advantage due to reduced costs for companies. The al
