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Oligomers are transient toxic species in amyloidoses such as Alzheimer's disease. The binding of oligomers by human chaperone proteins has been inferred from the lack of detectable interactions with monomeric amyloid proteins and delay of fibril formation at sub-stoichiometric chaperone to monomer molar ratios. In this study, we provide direct experimental evidence for the binding of the human cha
The Large Magellanic Cloud (LMC) and Small Magellanic Cloud (SMC) are the Milky Way’s nearest interacting galaxy pair, offering a unique laboratory for studying tidal effects on galactic disks. Despite extensive survey efforts, the 3D geometry of the Magellanic Clouds, particularly the putative warp of the LMC, remains poorly constrained due to incompleteness in their crowded centers and the low s
The aim of this work is to integrate a machine-learning (ML)-based meta-model into a conventional structural vibration model in a componentwise manner using dynamic substructuring. In dynamic substructuring, the finite element (FE) method is one of the popular ways of modeling substructures. In this study, we theoretically examine dynamic substructuring formulations for cases where an ML-based met
Context: Even within the physiological range, serum calcium (sCa++) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa2+ and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa2+ was measured in patients referre
OBJECTIVES: Patients with rheumatoid arthritis (RA) can reduce their increased risk for cardiovascular diseases and improve symptoms and quality of life with healthy lifestyle habits. This study aimed to explore patients' experiences of managing their lifestyle habits following a diagnosis of RA.METHODS: In this qualitative study, 20 patients with RA, 14 women, and 6 men, were included. Individual
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic disease that requires lifelong medication and self-management. Few studies have explored the coping strategies patients use to make life manageable after an RA diagnosis, and how these strategies function in the adaptive process of living with RA. The aim was to describe coping strategies patients with RA use to manage everyday life during the fir
OBJECTIVES: To develop a group-based COMbined Fatigue Intervention (COMFI) that integrates a cognitive behavioural approach with physical activity to enhance self-management of fatigue and reduce fatigue severity and impact in people with inflammatory arthritis (IA).METHODS: The development was guided by the British Medical Research Council's framework for complex interventions and was based on: (
BACKGROUND: Continuity of care is key for high-quality primary care, associated with improved health outcomes, reduced mortality and more efficient use of resources. Achieving relational continuity is challenging in systems with high provider choice and fragmented care-seeking. Sweden exemplifies this tension, combining broad access to primary care and low GP continuity.AIM: To examine how individ
Purpose – Research on management control for innovation has shifted from viewing control as primarily constraining to recognizing that control can also enable innovation. However, common ways of classifying control such as mechanisms, tools or types of use can understate what makes management control in innovation settings distinctive. This paper aims to propose a vocabulary to support richer expl
Firms struggle to translate sustainability ambitions into innovation practices, especially in crisis contexts where leaders must navigate ambiguity, competing demands, and rapid change. This study examines how top managers use sense-related practices to cultivate an adaptive space for sustainability-oriented innovation (SOI) under crisis-induced conditions. Drawing on an in-depth, process-oriented
This paper explores the role of boundary objects in the translation and transformation process of a sustainability concept-Sustainability Development Goals (SDGs)-into a firm's business practices. The qualitative case study describes the experience where a Japanese company successfully implemented SDGs and generated product innovations through its learning process. The findings of the study identi
This special publication demonstrates that the success of Swedish companies in the face of powerful global brands such as Starbucks, McDonald’s, and Burger King is not simply a matter of consumer nationalism or cultural resistance, but rather the result of the interaction between culture, institutions, and business strategy. Although Sweden appeared to be an ideal market for Starbucks, the company
Active small bodies in extrasolar systems, the extrasolar analogues of Solar System comets, provide insights into the orbital evolution and physical processes shaping planetary systems. Since the discovery of exocomets around β Pictoris, these small, icy bodies have shown the potential to become key probes for understanding planetary formation and migration. This review presents an overview of cur
Being publicly visible as an engaged employee persona has become an important asset in contemporary knowledge work. Social networking sites such as LinkedIn offerprofessionals new opportunities to present and perform the ideal worker identity to a broader audience. While engagement and the performance of the ideal worker persona have received attention across various research fields, often being a
The actors providing housing to students have historically balanced precariously between the desire to care for students and the desire for disciplining them. These conflicting desires produce a tension between care and discipline that permeate institutions of student housing and their buildings. The following chapter traces how this tension played out in the formation and the first years of Swede
OBJECTIVE: To evaluate a 3-month post-hip arthroscopy rehabilitation program within a randomized controlled trial comparing hip arthroscopy to sham surgery for femoroacetabular impingement syndrome (HIP ARThroscopy International [HIPARTI] trial) by describing exercise adherence, type, and pain; 6-month changes in International Hip Outcome Tool-33 (iHOT-33); and physical impairments and functiona
This paper explores the sociability among Shi`i women in Kuwait by examining non-mourning rituals such as the Taklif ceremony and the celebrations of Imam births. Using sociability as an analytical framework, the study highlights how these joyous events foster a sense of belonging, social cohesion, and religious devotion, contrasting them with the predominantly studied mourning rituals associated
Introduction: Type 1 diabetes is a chronic autoimmune disease, preceded by the presence of islet autoantibodies, a preclinical state defined as islet autoimmunity. Several environmental exposures have been associated with the initiation of islet autoimmunity but the triggers remain largely unknown. Rapid growth and weight gain during childhood are some of the exposures that have been proposed to p
Civil society organisations play numerous key roles in governing and practically enacting sustainable development. For rural development this importantly includes farmer-based organisations, which among other things can represent and amplify farmers’ voices. In sub-Saharan Africa, small-scale farmers in particular lack organisational vehicles for political influence. This study analyses an attempt
