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PURPOSE: Endothelin (ET)-1 has been implicated in the atherosclerotic process and during inflammation. Similarity in the development process of giant cell arteritis (GCA) and atherosclerosis exists. Several ET receptor antagonists have been developed, principally to target cardiovascular disease states. High doses of corticosteroids currently are used in the treatment of GCA, whereas other treatme

PURPOSE: Randomized multiple myeloma (MM) studies show improved response rates and better progression-free survival for newer therapies. However, a less pronounced effect has been found for overall survival (OS). Using population-based data including detailed treatment information for individual patients, we assessed survival patterns for all patients diagnosed with MM in Malmö, Sweden from 1950 t

The fifth harmonic of a 60-fs 10-Hz terawatt titanium:sapphire laser generated in Xe gas is used to ionize Xe and Kr atoms by nonresonant two-photon absorption and At atoms through a quasiresonant three-photon process. At relatively low harmonic yields, the variation of the number of Kr and Xe ions with the number of harmonic photons is quadratic. At high harmonic yields, it deviates from a quadra

The nonrandom behavior of the outputs of a random S-box can be exploited when constructing distinguishers for cryptographic primitives. Different methods of constructing samples from the outputs have been used in the literature. However, it has been unclear exactly how these methods differ and which method is optimal. We analyze four different sampling techniques. We prove that two of these sampli

We compared the incidence of cancer among Turkish, Chilean, and North African (NA) first-generation immigrants with residents in their countries of origin and native Swedes. The Swedish Family-Cancer Database was used to calculate age-standardized incidence rates. We compared the age-standardized incidence rates for immigrants with those in the Cancer Incidence in Five Continents report. All-cance

Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer, and it has been described as a potent antiandrogen in males. In this study, lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP (1, 10, and 100 mg/kg body weight) from pos

Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis of several neurodegenerative disorders. Activated microglia release pro-inflammatory factors that may be neurotoxic. Here we show that the orderly activation of caspase-8 and caspase-3/7, known executioners of apoptotic cell death, regulate microglia activation through a protei

Abstract Purpose: To explore the early reactions of the retinal Müller glia in response to retinal insult prior to gliotic remodeling and the sustained upregulation of intermediate filament glial fibrillary acidic protein (GFAP), which has traditionally been considered the most sensitive early indicator of reactive gliosis. Methods: To study pre-gliotic events, we used a model of adult rat retinal

Krönika om seriemördare i kriminaljournalistik och i populärkultur med anledning av fallet Thomas Quick

There is ample evidence for intra-patient evolution of the human immunodeficiency virus type 1 (HIV-1) biological phenotype during the pathogenic process. Evolution often involves switch of coreceptor use from CCR5 to CXCR4, but change to more flexible use of CCR5 occurs over time even in patients with maintained CCR5 use. The increasing use of entry inhibitors in the clinic, often specific for on

Better understanding of the impacts of an incident may help analysts to design more appropriate incident management strategies. Very little is known to date about the usefulness of applying data mining in traffic and transport related research, although data mining has contributed its usefulness significantly in other fields. This research is intended to discover the relationship between motor veh

Innehållet i denna paper är i stort detsamma som i papern publicerad i Philologica Jassyensia 2008, men föredraget vid denna konferens insisterar mer på hur vi har „byggt upp” olika studieaktiviteter i den virtuella miljön för att kunna uppnå en nästintill maximal flexibilitet respektive effektivitet i lärandet.