Perilipin 1 is a lipid droplet coating protein known to regulate lipid metabolism in adipocytes by serving as a physical barrier as well as a recruitment site for lipases to the lipid droplet. Phosphorylation of perilipin 1 by protein kinase A rapidly initiates lipolysis, but the detailed mechanism on how perilipin 1 controls lipolysis is unknown. Here, we identify specific lipid binding propertie

Liver fat can be non-invasively measured by proton magnetic resonance spectroscopy (1H-MRS) and fibrosis estimated as stiffness using transient elastography (FibroScan). There are no longitudinal data on changes in liver fat in Europids or on predictors of liver stiffness using these methods. We determined liver fat (1H-MRS) and clinical characteristics including features of insulin resistance at

The Mueilha granite pluton is one of the rare-metals bearing peraluminous granitic plutons in the Arabian-Nubian Shield. It represents the apical part of a highly evolved magma chamber emplaced at a shallow level subsequent to the post Pan-African orogeny. The pluton can be seen as a highly leucocratic medium-grained albite/oligoclase framework infilled with quartz, K-feldspar and muscovite that a

Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular BoNT/A injections (6 UI = 60 pg) on muscle tissue. The gait pattern of the rats was

We prove a result on separation of particles in a two-dimensional Coulomb plasma, which holds provided that the inverse temperature (Formula presented.) satisfies (Formula presented.). For large (Formula presented.), separation is obtained at the same scale as the conjectural Abrikosov lattice optimal separation.

We present a compact implementation of the ultrashort pulse measurement technique based on dispersion scans (d-scan), allowing single-shot measurement of few-cycle pulses. The main novelty in our design, making our setup extremely compact and simple, is the use, after a prism, of a spherical mirror in an off-axis geometry. The intentionally introduced strong astigmatism makes it possible to image

Integrating photosynthetic cell components with nanostructured materials can facilitate the conversion of solar energy into electric power for creating sustainable carbon-neutral energy sources. With the aim at exploring efficient photoinduced biocatalytic energy conversion systems, we have used an amidated carbon nanotube (aCNT) networked matrix to integrate thylakoid membranes (TMs) for construc

Membrane-active peptides (MAPs) are able to induce pores in cell membranes via molecular mechanisms, which are still subject to ongoing research. In this work, we present molecular dynamics simulations that suggest a precursor membrane defect plays an important role in the pore-inducing activity of the prototypical antimicrobial peptide melittin. The simulations reveal that the hydrophobic N-termi

Nutrients constrain the soil carbon cycle in tropical forests, but we lack knowledge on how these constraints vary within the soil microbial community. Here, we used in situ fertilization in a montane tropical forest and in two lowland tropical forests on contrasting soil types to test the principal hypothesis that there are different nutrient constraints to different groups of microorganisms duri

Horseflies (Tabanidae) are polarotactic, being attracted to linearly polarized light when searching for water or host animals. Although it is well known that horseflies prefer sunlit dark and strongly polarizing hosts, the reason for this preference is unknown. According to our hypothesis, horseflies use their polarization sensitivity to look for targets with higher degrees of polarization in thei

Svenska Dagbladet 19/11 2017, understreckare med anledning av att antologin "Tre sekler av svenska pekoral" är under utgivning.

Having multiple control tasks concurrently running on a single computing platform increases the processor utilization but degrades the control performance due to delay and jitter. In scheduling and control codesign, the objective is to optimize the combined performance of all the controllers, subject to a schedulability constraint. The codesign procedure consists of selecting task parameters, e.g.

Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans,trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behavior of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the

Funerary poems on animals form a subgenre of the standard epitaph written to commemorate a deceased person. The poet who created the conditions necessary for the establishment of this kind of poetry in Sweden was the queen dowager Hedvig Eleonora’s court poet Erik Lindschöld (1634–1690); his poems mourning the death of the queen’s bitches were presumably composed in the 1670s. These poems constitu

Seed orchards function as the primary source of high-quality seeds for reforestation in many European countries, but their seed yields can be severely reduced due to seed- and cone-feeding insects. We evaluated various parameters of pheromone-based mating disruption for control of the moths Cydia strobilella and Dioryctria abietella, which are major pests in European Picea abies seed orchards. We

Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childh