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Pointwise limit distribution results are given for the isotonic regression estimator at a point of discontinuity. The cases treated are independent data, phi- and alpha-mixing data and subordinated Gaussian long range dependent data. Pointwise limit results for the nonparametric maximum likelihood estimator of a monotone density are given at a point of discontinuity, for independent data. The limi
To investigate a putative involvement of protein kinase C (PKC) isoforms in supporting neuroblastoma cell proliferation, SK-N-BE(2) neuroblastoma cells were transfected with expression vectors coding for the C2 and V5 regions from different PKC isoforms. These structures have been suggested to inhibit the activity of their corresponding PKC isoform. The PKC fragments were fused to enhanced green f
Background Open abdomen (OA) treatment often results in difficulties in closing the abdomen. Highest closure rates are seen with the vacuum-assisted wound closure (VAWC) technique. However, we have experienced occasional failures with this technique in cases with severe visceral swelling needing longer treatment periods with open abdomen. Feasibility and short-term outcome of a novel combination o
In this essay, an attempt is made to derive a model of interpretation from the conception of the sign developed in semiotics. The kind of interpretation discussed here involves the intervention of a interpreting subject between the sender and the receiver of a primary act of communication; this is different from interpretation in the sense of a second act of communication, taking its point of depa
Objective. To study to what extent geographical differences of the mortality from ischaemic heart disease (IHD) can be accounted for by the 28-day case fatality rate (CFR) following first hospital admittance for acute myocardial infarction (MI) and whether the geographical pattern of survival has any relationship with socio-economic circumstances. Design. Register-based surveillance study. Setting
The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimate
The aim of this thesis is to examine the relationship between writing and alterity in three recent novels written by J. M. G. Le Clézio, Désert (1980), Onitsha (1991) and La quarantaine (1995), which deal with the encounter between the so-called primitive cultures and Western society. The first chapter contains a more general discussion on the discourse of alterity in literature and the French exo
We describe two patients with Grisel syndrome (atlantoaxial dislocation) after velopharyngoplasty. One required open fixation, while the other was treated with closed reduction and skull traction. Both patients recovered well after long-term follow-up. Early detection and appropiate treatment improve the prognosis.
Stained fluorescent hyphae were picked out from soil using a Skerman micromanipulator. About 30% of the plated out hyphae produced visible colonies, at least half of which could be considered to be derived from hyphae, The dominating genera were Penicillium, Oidiodendron and Mortierella. Non-sporulating fungi were rather few (4'5%). Results were compared with those obtained using the dilution plat
We measure the amplitude of the elastomechanical displacement at a fine grid of points on a free plate having the shape of a Sinai stadium. The obtained displacement field formally corresponds to a wave function in a quantum system. While the distribution of the squared amplitudes agrees with the prediction of random matrix theory (RMT), there is a strong deviation of the spatial correlator from t
This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates material presented and discussed during the Symposium on the European Strategy for Particle Physics, he
Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene enco
Abstract is not available
A critical review is presented on the state of knowledge and calculation capability for coastal overwash. Overwash and overwash deposits (washover) accompanying hurricanes and severe storms can devastate coastal communities and habitat, but in many areas these processes are essential for maintaining the integrity of barrier islands while creating new habitat. This review covers general studies of
The aim of this study was characterization of a family carrying two mutations known to cause monogenic forms of diabetes, the M626K mutation in the HNF1α gene (MODY3) and the A3243G in mtDNA. β-Cell function and insulin sensitivity were assessed with the Botnia clamp. Heteroplasmy of the A3243G mutation and variants in type 2 diabetes susceptibility genes were determined, and transcriptional activ
