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BACKGROUND AND OBJECTIVE: BRCA1 and BRCA2 pathogenic germline variants (PGVs) are associated with higher risk of prostate cancer (PC). The IMPACT study evaluated the utility of targeted prostate-specific antigen (PSA) screening in BRCA1/BRCA2 PGV carriers. Here we report outcomes after five rounds of PSA screening in IMPACT.METHODS: Between 2005 and 2015, 3063 participants aged 40-69 yr (median 54

Under en inventering av djurlivet i Lunds universitets Botaniska trädgårds växthus påträffades i januari 1982 40 st olika arter. Av dessa var mer än hälften av utländskt ursprung och har sannolikt ursprungligen medföljt växtsändningar från andra växthus. Två gråsuggor (Armadillidium nasutum och Trichorhina monocellata) har troligtvis ej tidigare blivit funna i Sverige. Uppgifter ges om de påträffa

we propose to fully integrate EHRDs rights in the roadmap for phasing out fossil fuels with the aim to uphold a pace that is required to catalyse climate justice for the most affected peoples and territories. A phase-out fossil fuel roadmap should consider the central role they have in protecting life on Earth, safeguarding the climate and environment, thriving biodiversity and leading pathways to

How long do fungal hyphae persist in the environment? And how does this differ betweengroups and species of fungi? Despite growing knowledge of fungal contributions to decom-position and soil carbon cycles, surprisingly little is known about the turnover of mycelia:What happens to fungal hyphae over time? And how this impacts different fungi’s contribu-tion to carbon sequestration?In this study, w

Remanufacturing is a key strategy in the circular economy, enabling substantial product value retention. However, inconsistent definitions across standards and legislation hinder global trade, core recovery and market acceptance. This study examines how remanufacturing is defined in laws and standards, and how these definitions impact industry practices. Through a literature review of key existing

Denna uppsats undersöker den politiska teaterns roll och potential att skapa verklig samhällsförändring. Utifrån ett materialistisk perspektiv ställs frågan huruvida teatern, som primärt verkar i åskådarens medvetande, är begränsad till att enbart förändra tankesätt eller om den även kan vara ett direkt medel för konkret politisk och materiell förändring. Syftet är att kartlägga vår tids svårighet

Background Multimorbidity, the co-occurrence of two or more non-communicable diseases (NCDs), is common and has been linked to venous thromboembolism (VTE). Whether multimorbidity diagnosed in primary-care is associated with incident VTE remains unclear. We aimed to examine this association. Methods Multimorbidity was defined using Swedish primary-care data. Individuals without prior VTE were incl

PURPOSE: The systolic blood pressure (SBP) response to exercise reflects cardiovascular health, with both exaggerated and blunted responses linked to adverse outcomes. Prior studies relied typically on peak SBP or two-point slopes for evaluation. We aimed to identify distinct SBP responses from full times-series recorded during maximal, graded exercise and assess their clinical determinants and pr

BACKGROUND: Our aim was to explore the reasoning and experiences of women when offered a self-sampling HPV test.METHODS: This study implemented a qualitative study design and content analysis using an inductive approach. Data consisted of written narratives collected through open-ended questions from a total of 173 women. Women were included if they had been offered a self-sampling device since Se

The capacity for birds to adjust their breeding time to variation in spring temperature via plasticity is crucial for insectivorous passerines in temperate areas, particularly in a context of climate disruptions. Recent studies suggested that phenological plasticity varies in response to environmental change via urbanization. We investigated the effects of urbanization on laying date, its phenotyp

We investigate how differences in the stellar feedback produce disks with different morphologies in Milky Way-like progenitors over 1 ≤ z ≤ 5, using eight state-of-the-art cosmological hydrodynamics simulation codes in the AGORA project. In three of the participating codes, a distinct, rotation-dominated inner core emerges with a formation timescale of ≲300 Myr, largely driven by a major merger ev

Populärvetenskaplig sammanfattning:Elfordon uppfattas ofta som en modern uppfinning, men elektriskt drivna fordon har funnits sedan slutet av artonhundratalet. De första helelektriska personbilarna, bussarna och lastbilarna utvecklades redan innan förbränningsmotorn slog igenom.För att förstå varför elektriska störningar spelar en så viktig roll i dagens elfordon kan man börja med en enkel bild. TThe rapid electrification of heavy-duty vehicles has introduced traction voltage systems (TVS) with electrical scale and complexity not previously seen in on-road applications. Multiple power electronic subsystems interact through long cables and frequency-dependent impedances, making conducted electromagnetic interference (EMI) a system-level phenomenon. Differential-mode (DM) and common-mode (CM

In 1807, Britain outlawed the slave trade across its empire. Yet in the Cape Colony, households continued accumulating slaves for decades afterwards. New evidence from digitised tax censuses suggests the answer lies not in labour demand, but in the financial value of enslaved people as capital assets.