The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics approach, we found that CSPG4, MCAM, and AOC3 correlate with MYOCD, MRTF-A/MKL1, and SRF across human tissues. No other transcription factor correlat

Background: Contamination of drinking water by hazardous chemicals can be associated with human health risks. Recent studies using effect-based in vitro methods have demonstrated that a large part of the observed toxic effects are caused by unknown chemicals. In this study, we have used a panel of effect-based methods to study the presence of chemical contaminants in a unique material; glass-bottl

Background: Researchers have shown an increased interest in involving professionals from outside academia in research projects. Professionals are often involved in research on ageing and health when the purpose is to address the gap between research and practice. However, there is a need to acquire more knowledge about what the involvement might lead to by exploring researchers’ experiences of inv

The use of organic mulch is important for urban green applications. For urban areas in arid and semiarid regions receiving short high-intensive rainfall, rainfall characteristics, and soil slope play an important role for mulch functioning. These properties of mulch were studied. For this purpose, rainfall simulation experiments using organic mulching were conducted in Jiufeng National Forestry Pa

Anolis lizards originated in continental America but have colonized the Greater Antillean islands and recolonized the mainland, resulting in three major groups (Primary and Secondary Mainland and Greater Antillean). The adaptive radiation in the Greater Antilles has famously resulted in the repeated evolution of ecomorphs. Yet, it remains poorly understood to what extent this island radiation diff

The boreal forest is among the largest terrestrial biomes on earth, storing more carbon (C) than the atmosphere. Due to rapid climatic warming and enhanced human development, the boreal region may have begun transitioning from a net C sink to a net source. This raises serious concern that old biogenic soil C can be re-introduced into the modern C cycle in near future. Combining bio-decay experimen

Background: In childhood cancer care, healthcare professionals must deal with several difficult moral situations in clinical practice. Previous studies show that morally difficult challenges are related to decisions on treatment limitations, infringing on the child's integrity and growing autonomy, and interprofessional conflicts. Research also shows that healthcare professionals have expressed a

The discovery of superconductivity above 250 K at high pressure in LaH10 and the prediction of overcoming the room temperature threshold for superconductivity in YH10 urge for a better understanding of hydrogen interaction mechanisms with the heavy atom sublattice in metal hydrides under high pressure at the atomic scale. Here we use locally sensitive X-ray absorption fine structure spectroscopy (

Abstract in Undetermined Applications of physical bounds for electromagnetic radiators can be used to derive a priori estimates for antenna parameters in terms of the directivity-bandwidth product. These estimates relate the static electric and magnetic polarizability of the radiating structure to its dynamic properties. The results have previously been illustrated for dipole radiators with good aApplications of physical bounds for electromagnetic radiators can be used to derive a priori estimates for antenna parameters in terms of the directivity-bandwidth product. These estimates relate the static electric and magnetic polarizability of the radiating structure to its dynamic properties. The results have previously been illustrated for dipole radiators with good agreement. Here, the bound

The frequency dependence of the permittivity, permeability, and index of refraction restrict metamaterial applications such as cloaking and perfect lenses. Here, the principles of causality and passivity together with identities for Herglotz functions are used to construct various sum rules. The sum rules relate the frequency dependence of the material parameters with their high- and low-frequency

I denna AMM-rapport presenteras åtgärdsförslag som syftar till att förbättra skolledares arbetsmiljö. Rapporten är en del av forskningsprojektet ”Skolledares arbetsmiljö: Ett projekt om organisatoriska förutsättningar, stressrelaterad psykisk ohälsa, personalrörlighet och förbättringspotential” som finansierats av AFA Försäkring (dnr 170094). Åtgärdsförslagen har samlats in med hjälp av enkäter, g

Colour polymorphisms are popular study systems among biologists interested in evolutionary dynamics, genomics, sexual selection and sexual conflict. In many damselfly groups, such as in the globally distributed genus Ischnura (forktails), sex-limited female colour polymorphisms occur in multiple species. Female-polymorphic species contain two or three female morphs, one of which phenotypically mat

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to plants (although the enzyme itself is strictly microbial). It has been studied extensively with both experimental and computational methods, but many details of the reaction mechanism are still unclear. X-ray crystallography is the main source of structural information for biomacromolecules, but it h

Global steel production is currently dependent on coal and capital-intensive production facilities with long economic lifetimes. While the Paris Agreement means carbon neutrality must be reached globally by 2050–2070, with negative emissions thereafter, coal-based steel production today accounts for around 8% of global energy-related CO2 emissions. Its production may stabilize or even decline in i

The Nehruvian policies propagated upon India’s independence envisaged no place for religion in political mobilization. Still, religion has continued to affect and influence Indian politics, even as India has become progressively affected by processes of liberalization and globalization. The particular politics of Indian secularism was based on keeping a distance from matters of faith and custom. H

It is increasingly evident that the centre of gravity of international relations is shifting in the direction of Asia. China’s economic and political rise is the single most important dimension of this development. This coincides with fading American hegemony, obvious during, but in essence not limited to, the Trump Presidency. These actor-level changes take place within a context of structural chIt is increasingly evident that the centre of gravity of international relations is shifting in the direction of Asia. China’s economic and political rise is the single most important dimension of this development. This coincides with fading American hegemony, obvious during, but in essence not limited to, the Trump Presidency. These actor-level changes take place within a context of structural ch

Background: The characteristics of Parkinson's disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability. Research question: What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effe

Heparin and heparan sulfate (HS) are linear sulfated disaccharide polymers. Heparin is found mainly in mast cells, while heparan sulfate is found in connective tissue, extracellular matrix and on cell membranes in most tissues. α1-microglobulin (A1M) is a ubiquitous protein with thiol-dependent antioxidant properties, protecting cells and matrix against oxidative damage due to its reductase activi