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Volume Tracking: A new method for quantitative assessment and visualization of intracardiac blood flow from three-dimensional, time-resolved, three-component magnetic resonance velocity mapping

Background: Functional and morphological changes of the heart influence blood flow patterns. Therefore, flow patterns may carry diagnostic and prognostic information. Three-dimensional, time-resolved, three-directional phase contrast cardiovascular magnetic resonance (4D PC-CMR) can image flow patterns with unique detail, and using new flow visualization methods may lead to new insights. The aim o

Biomimetic macroporous hydrogel scaffolds in a high-throughput screening format for cell-based assays.

Macroporous hydrogels (MHs) hold great promise as scaffolds in tissue engineering and cell-based assays. In this study, the possibility of combination of three-dimensional (3D) cell culture with a miniaturized screening format was demonstrated on human colon cancer HCT116, human acute myeloid leukemia KG-1 cells, and embryonic fibroblasts cultured on MHs (12.5 mm x 7.1 mm I.D.) in a 96-minicolumn

Bystander hyperactivation of preimmune CD8(+) T cells in chronic HCV patients

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-spe

Long-term stability of return to work after a workplace-oriented intervention for patients on sick leave for burnout.

The period from the mid-1990s to the mid-2000s saw a rapid increase in long-term sick leave in Sweden, primarily due to mental illness and often related to job burnout. This led to an urge for effective treatment programs that could prevent the often long sick leaves. In 2010 we presented a newly developed work-place intervention method, showing that 89% of the intervention group had returned to w

The mu TPC method: improving the position resolution of neutron detectors based on MPGDs

Due to the He-3 crisis, alternatives to the standard neutron detection techniques are becoming urgent. In addition, the instruments of the European Spallation Source (ESS) require advances in the state of the art of neutron detection. The instruments need detectors with excellent neutron detection efficiency, high rate capabilities and unprecedented spatial resolution. The Macromolecular Crystallo

FactorVIIa and its potential therapeutic use in bleeding-associated pathologies

Recombinant FVIIa (rFVIIa) was developed for treatment of haemophilia patients with inhibitors against FVIII/FIX. The haemostatic efficacy rate of 80-90% including major orthopaedic surgery (dosing of 90-120 mu g/kg every other hour [h] for at least the first 24 h) was achieved in these patients. In a home-treatment setting the efficacy rate of haemostasis in mild-moderate bleedings was 92% (avera

Patient education for alcohol cessation intervention at the time of acute fracture surgery: study protocol for a randomised clinical multi-centre trial on a gold standard programme (Scand-Ankle).

Patients with hazardous alcohol intake are overrepresented in emergency departments and surgical wards. These patients have an increased risk of postoperative complications with prolonged hospital stays and admissions to intensive care unit after surgery. In elective surgery, preoperative alcohol cessation interventions can reduce postoperative complications, but no studies have investigated the e

Intravenous contrast ultrasound examination using contrast-tuned imaging (CnTI (TM)) and the contrast medium SonoVue (R) for discrimination between benign and malignant adnexal masses with solid components

Objective To determine whether intravenous contrast ultrasound examination is superior to gray-scale or power Doppler ultrasound for discrimination between benign and malignant adnexal masses with complex ultrasound morphology. Methods In an international multicenter study, 134 patients with an ovarian mass with solid components or a multilocular cyst with more than 10 cyst locules, underwent a st

Testing Latour's app: a user's guide

I reconstruct Bruno Latour's ideas about science and religion and compare them to Ian G. Barbour's and Mikael Stenmark's models, as well as to the discussion of technology and religion developed by John C. Caiazza and Antje Jackelen. I show how using "Latour's App" enlightens some aspects of said models which Barbour and Stenmark themselves were seemingly struggling with, and that Caiazza's and Ja

Adjuvant chemotherapy for endometrial cancer after hysterectomy

Background Endometrial adenocarcinoma (womb cancer) is a malignant growth of the lining (endometrium) of the womb (uterus). It is distinct from sarcomas (tumours of the uterine muscle). Survival depends the risk of microscopic metastases after surgery. Adjuvant (postoperative) chemotherapy improves survival from some other adenocarcinomas, and there is evidence that endometrial cancer is sensitive

A Comparative Analysis of WHR System in HD Engines Using Conventional Diesel Combustion and Partially-Premixed Combustion

In the truck industry there is a continuous demand to increase the efficiency and to decrease the emissions. To acknowledge both these issues a waste heat recovery system (WHR) is combined with a partially premixed combustion (PPC) engine to deliver an efficient engine system. Over the past decades numerous attempts to increase the thermal efficiency of the diesel engine has been made. One such at

Abundance of arbuscular mycorrhizal fungi in relation to soil salinity around Lake Urmia in northern Iran analyzed by use of lipid biomarkers and microscopy

Saline soils around Lake Urmia in northern Iran constitute a stressed environment for plants and microbial communities, including arbuscular mycorrhizal (AM) fungi. Soil and root samples were collected from fields cultivated with the glycophytes Allium cepa L. and Medicago sativa L, and sites dominated by the halophyte Salicornia europaea L. Soil and root samples were analyzed for the AM fungal si

Pattern of Five-Year Weight Change by Age and Birth Cohorts in a Swedish Adult Population

The driving factors behind the global epidemic of obesity have not yet been fully elucidated. Investigating the effect of age and cohort on weight change might enable us to develop effective intervention strategies. Aims To analyse the pattern of BMI change by age and birth cohort over five-year follow-up in adult Swedish sample. Methods The data was drawn from the Scania Public Health Cohort. The

Two Ports Laparoscopy-Assisted Colostomy in Neonates : A Method Described

This is a description of the technique used for laparoscopy-assisted colostomy in neonates with anorectal malformations (ARM), using 2 laparoscopic ports only. The technique is easy to use and has the advantages of enabling identification of the sigmoideum, the internal genitals and to establish a stoma leaving only minimal scars in the umbilicus. In our departments, we routinely perform stoma ope

The Gaia-ESO Survey: Abundance ratios in the inner-disk open clusters Trumpler 20, NGC 4815, NGC 6705

Context. Open clusters are key tools to study the spatial distribution of abundances in the disk and their evolution with time. Aims. Using the first release of stellar parameters and abundances of the Gaia-ESO Survey, we analyse the chemical properties of stars in three old/intermediate-age open clusters, namely NGC 6705, NGC 4815, and Trumpler 20, which are all located in the inner part of the G