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Experimental Stem-Cell Based Therapy in Pediatrics : A Fictional Case Study
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From an Information Consumer to an Information Author : the Role of Self-Service Business Intelligence
Self-service business intelligence (SSBI) enables executives, managers, analysts and knowledge workers to access data and build reports based on their needs to support decisions and actions toward business success. This suggests that business users not only consume information but that they are also able to author information. This discourse remains concentrated at an industrial level, and there i
Meteorite flux to Earth in the Early Cretaceous as reconstructed from sediment-dispersed extraterrestrial spinels
We show that Earth’s sedimentary strata can provide a record of the collisional evolution of the asteroid belt. From 1652 kg of pelagic Maiolica limestone of Berriasian–Hauterivian age from Italy, we recovered 108 extraterrestrial spinel grains (32–250 μm) representing relict minerals from coarse micrometeorites. Elemental and three oxygen isotope analyses were used to characterize the grains, pro
Cartilage matrix remodelling differs by disease state and joint type
Dramatic alterations in mechanical properties have been documented for osteoarthritic (OA) cartilage. However, the matrix composition underlying these changes has not been mapped and their aetiology is not entirely understood. We hypothesised that an understanding of the cartilage matrix heterogeneity could provide insights into the origin of these OA-related alterations. We generated serial trans
Decentralisation : An Asian Perspective
Analysis of Deformation of Gas Diffusion Layers and the Impact on Performance of PEM Fuel Cells
Proton exchange membrane (PEM) fuel cells have been promoted due to significant breakthroughs in various aspects and increasing public interests. The porous features of the gas diffusion layer (GDL) and the necessary assembly processes generate localized pressure forces on the channel/shoulder structure of the bi-polar plates (BPP). As a consequence, the assembly pressure acting on a single cell a
Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. Tissue microarrays derived from two cohorts of patients with breast cancer (n=122 and n=498) were immunostained, revealing varying expression of COMP, both in the tumor cells and surrounding stroma. High levels of COMP in tumor cells correlated, independently of
Uncertainty and Discrimination : Family Structure and Declining Child Sex Ratios in Rural India
Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes.METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5
Stae, Community and Resources
Enhancing Information Quality as part of the disease surveillance system in Malawi, Africa: reflections on a mHealth intervention
Tools and annotations for variation
Since the finishing of the Human Genome Project, many next-generation (NGS) or high-throughput sequencing platforms have emerged. One of the applications of NGS technology, variant discovery, can serve as a basis for precision medicine. Large sequencing projects are generating huge amounts of genetic variation data, which are stored in databases, either large central databases such as dbSNP, or ge
Contribution by Departments of Forensic Medicine to Tissue Donation for Transplant Purposes
BACKGROUND: A department of forensic medicine (DFM) can be a valuable source for tissue donation, but logistics can prove difficult to overcome as it pertains to obtaining tissues for donation. This article describes the potential of tissues that can be procured for transplantation.MATERIALS AND METHODS: Sweden has 9.7 million inhabitants, with an annual mortality rate of 90 000 and 5500 medicoleg
Physical aggression among patients with dementia, neuropathologically confirmed post-mortem
ObjectiveTo investigate the prevalence of physical aggression among patients with dementia of different types and to analyze potential differences in clinical traits, in terms of singular or repetitive behavior and occurrence in early or late stage of the disease. We also aimed at examining against whom the physical aggression was exerted.MethodsWe included 281 cases with a neuropathological demen
The Use of Exposure Models in Assessing Occupational Exposure to Chemicals
Physical neglect during childhood alters white matter connectivity in healthy young males
Background: Childhood adversity (CA) leads to greater vulnerability for psychopathology by causing structural as well as functional brain abnormalities. Recent findings on gray matter effects point towards the importance of identifying CA outcome as a function of different CA types, varying in the dimensions of threat and deprivation. Using diffusion tensor imaging, we investigate whether differen
From Conflict to Compromise : The importance of mediation in Swedish work stoppages 1907-1927
Institutions for prevention and resolution of labor market conflicts were introduced all over the world in the early twentieth century. In this paper we analyze the impact of mediation on compromise outcomes in Swedish labor market conflicts, using a dataset of geo-coded strikes and lockouts from 1907 to 1927. Causality is identified by using the distance from the mediator's residence to the confl
In search of features that constitute an "enriched environment" in humans : Associations between geographical properties and brain structure
Enriched environments elicit brain plasticity in animals. In humans it is unclear which environment is enriching. Living in a city has been associated with increased amygdala activity in a stress paradigm, and being brought up in a city with increased pregenual anterior cingulate cortex (pACC) activity. We set out to identify geographical characteristics that constitute an enriched environment aff