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Background-eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). Methods and Results-In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucl
BACKGROUND: The need for equivalent results of routine measurement procedures for the alcohol biomarker carbohydrate-deficient transferrin (CDT) has been recognized by the IFCC. This article describes a project to harmonize CDT as conducted by an IFCC working group initiated for this purpose. METHODS: We used procedures for achieving harmonization as developed by the Consortium for Harmonization o
To date, there have been several detections of high-mass black hole binaries in both the Milky Way and other galaxies. For some of these, the spin parameter of the black hole has been estimated. As many of these systems are quite tight, a suggested origin of the spin is angular momentum imparted by the synchronous rotation of the black hole progenitor with its binary companion. Using Cygnus X-1, t
Celiac disease is an autoimmune disease characterized by inflammation localized to the small bowel, but less is known about systemic signs of inflammation. The aim was to measure cytokines of the T helper 1 (Th1) and T helper 2 (Th2) cell patterns in children with screening detected celiac disease before and after treatment with a gluten free diet.
The concept of ethnocultural empathy has been put forward as a variable that could explain tolerance between individuals and groups of different ethnic and cultural background. However, it is not clear if ethnocultural em-pathy is distinct from basic empathy. In this study we investigated the association between basic empathy, as measured by the Interpersonal Reactivity Index (Davis, 1983) and eth
Prognostication after cardiac arrest and therapeutic hypothermia is challenging. Recent data indicate that a subgroup of patients with postanoxic status epilepticus may recover. We describe a case of postanoxic status epilepticus with good outcome where a multimodal prognostic strategy motivated active and prolonged treatment. Our patient was a 61-year-old woman resuscitated from out-of-hospital c
Systemic lupus erythematous (SLE) is an autoimmune disorder that primarily affects young women and is characterized by inflammation in several organs including the kidneys, skin, joints, blood, and nervous system. Abnormal immune cellular and humoral responses play important roles in the development of the disease process. Impaired clearance of apoptotic material is a key factor contributing to ac
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cogniti
The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with t
This Letter presents a search for pair production of heavy down-type quarks decaying via b' -> Wt in the lepton + jets channel, as b'(b) over bar' -> W(-)tW(+)(t) over bar -> b (b) over barW(+)W(-)W(+)W- -> l(+/-) nu b (b) over barq (q) over barq (q) over barq ($) over barq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of
In animals, exposure to certain phthalates negatively affects the male reproductive function. Human results are conflicting and mostly based on subfertile males, in whom the association between exposure and reproductive function may differ from the general population.
The aim of this study was to investigate if future thinking would change following two forms of Internet-delivered cognitive behavior therapy (ICBT) for major depression. A second aim was to study the association between pre-post changes in future thinking and pre-post changes in depressive symptoms. Effects of psychological treatments are most often tested with self-report inventories and seldom
Ecophysiological research aiming at explaining the causes and consequences of variation in individual condition, health state, and allostasis is traditionally performed on captive animals under controlled laboratory conditions. The question about how captivity per se affects studied parameters is therefore of central importance for generalizing the information gained from such studies. We addresse
Characterization of molecules within important oncogenetic pathways may have future implications for development of therapies and biomarkers in lung cancer. One such target is the tyrosine kinase receptor KIT (c-KIT). We evaluated alterations and expression of KIT and its ligand, KITLG (also known as SCF), in 72 clinical lung tumor specimens of different histologies. Gene copy number, mRNA express
The Romanian language lectureship in Trondheim was established on 5th June 2008. This is the date when an agreement was signed between The Institute of the Romanian Language, represented by its director, Mrs. Ionela Dabija, and Norges Teknisk-Naturvitenskapelige Universitet (NTNU) [Norwegian University of Science and Technology], represented by professor Arne Halvorsen, the head of Institutt for m
The history of scientific illustrations is a story that correspond the cultural, economic, political and scientific history of the world. A look into the history of sciences displays that pictures and illustrations had a decisive role for the sciences progressive success and rising societal status from the sixteenth century. The illustrations visualized the unknown to graspable facts. Without the
Background No comprehensive systematic review of the accuracy of glomerular filtration rate (GFR) measurement methods using renal inulin clearance as reference has been published. Study Design Systematic review with meta-analysis of cross-sectional diagnostic studies. Setting & Population Published original studies and systematic reviews in any population. Selection Criteria for Studies Index
In retinal transplantation experiments it is hypothesized that remaining diseased photoreceptor cells in the host retina and inner retinal cells in transplants physically obstruct the development of graft-host neuronal contacts which are required for vision. Recently, we developed methods for the isolation of donor photoreceptor layers in vitro, and the selective removal of host photoreceptors in
Due to the positive effects demonstrated in randomized clinical trials on cardiovascular surrogate markers and bone metabolism, a positive effect of growth hormone (GH) treatment on clinically relevant end-points seems feasible. In this review, we discuss the long-term efficacy and safety of GH treatment in adult patients with growth hormone deficiency (GHD) with emphasis on morbidity: fatal and n
Here we present a study of the relationship between July-August (JA) mean climate over China, which is strongly linked to the East Asian summer monsoon (EASM), and the summer (JA) North Atlantic Oscillation (SNAO). The variations of temperature, precipitation, and cloud cover related to the SNAO were analyzed for the period 1951-2002 using gridded data sets as well as instrumental data from 160 st
