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PURPOSE. To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. METHODS. Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT), and fundus autofluorescence photography (FAF). Genetic analysis of the BEST1
Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of
Cellulose dissolution and regeneration is an increasingly active research field due to the direct relevance for numerous production processes and applications. The problem is not trivial since cellulose solvents are of remarkably different nature and thus the understanding of the subtle balance between the different interactions involved becomes difficult but crucial. There is a current discussion
Background: Serum protein profiles have been investigated frequently to discover early biomarkers for breast cancer. So far, these studies used biological samples collected at or after diagnosis. This may limit these studies' value in the search for cancer biomarkers because of the often advanced tumor stage, and consequently risk of reverse causality. We present for the first time pre-diagnostic
The Arctic is rapidly transitioning toward a seasonal sea ice-free state, perhaps one of the most apparent examples of climate change in the world. This dramatic change has numerous consequences, including a large increase in air temperatures, which in turn may affect terrestrial methane emissions. Nonetheless, terrestrial and marine environments are seldom jointly analyzed. By comparing satellite
α1-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding anti-oxidative functions. In addition, exposure of A1M to hemoglobin has been shown to induce proteolytic elimination of a C-terminal tetrapeptide yielding a heme-degrading form, truncated A1M (t-A1M). Myeloperoxidase (MPO), a heme-containing enzyme that catalyzes the production of fr
Popular Abstract in Swedish Den vanligaste barncancerformen är akut leukemi, en form av blodcancer som uppstår i immunförsvarets celler och som drabbar cirka 75 barn i Sverige varje år. Även om de flesta av barnen idag botas får en av fem återfall och då minskar överlevnaden drastiskt trots intensiv behandling. Vad det är som gör leukemin mer motståndskraftig när den återkommer vet man ännu inte iAcute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. Proper classification is important because determining the correct subtype plays a vital role
BACKGROUND AND PURPOSE: Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites. METHODS: Thirty patients with significant carotid sten
It has been suggested that speakers with an L1 with lexical tones may have an advantage when it comes to perceptually discriminating between different tones in another tone language (Kaan, Wayland, Bao & Barkley, 2007). Other studies in L2-learning show that this is not entirely the case (van Dommelen & Husby 2009, So & Best 2010). A model of typological pitch prominence (Schaefer &
Abstract in UndeterminedThe objective of the report is to analyse simulation results coming from the use of a policy evaluation method that encompasses a wider set of determinants for technology choice. To that end, we use the EEB_Sweden model v1.0. Still in an early stage of development, the model offers an opportunity to capture or integrate critical modelling aspects that justify our research p
Equilibrium fluctuation analysis of single binding events has been used to extract binding kinetics of ligand interactions with cell-membrane bound receptors. Time-dependent total internal reflection fluorescence (TIRF) imaging was used to extract residence-time statistics of fluorescently stained liposomes derived directly from cell membranes upon their binding to surface-immobilized antibody fra
In the Nordic countries machine strength grading of structural timber is becoming increasingly important. A new standard, EN 14081, which allows CE-marking of strength graded structural timber was recently accepted. This standard allows both machine
control and output control as methods for controlling the graded timber. Machine control is most commonly used in Europe. The project reporte
Background: Exercise facilities may have the potential to promote physical activity among residents, and to support an active lifestyle throughout the year. We investigated the association between objectively assessed availability of exercise facilities and objectively assessed physical activity outcomes, and whether time of year had a modifying effect on these associations. Methods: A total of 2,
Gravitational scattering in the ADD-model is considered at both sub- and transplanckian energies using a common formalism. By keeping a physical cut-off in the KK tower associated with virtual KK exchange, such as the cut-off implied from a finite brane width, troublesome divergences are removed from the calculations in both energy ranges. The scattering behavior depends on three different energy
