Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain. Here we investigated whether neuronal cultures derived from human induced pluripotent stem cells (hiPSCs) feature key advantages compared with rodent primary cultures. Using calcium fluorescence imaging, we tracked

The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent h

An 8-band k · p theory is implemented for studying the electronic properties of near-surface lateral InxGa(1-x)As/InP heterostructure nanowires in the (100) direction. The change in bandgap and effective mass due to inhomogeneous strain are compared to unstrained scenario nanowires, and the lattice mismatch is varied from -3.2% to 1%. The nanowires' height is H = 5, 13 nm, and the width varies fro

Flicker, or more precisely temporal light modulation (TLM), has re-emerged as a problem with the introduction of LED-based lighting technology. TLM, meaning variations in light intensity over time, may have negative effects on human health, causing annoyance, headaches, eyestrain and migraine. In addition to the unnecessary suffering TLM causes in individuals, the negative consequences of TLM crea

Understanding mechanisms involved in speciation can be challenging, especially when hybridization or introgression blurs species boundaries. In bats, resolving relationships of some closely related groups has proved difficult due subtle interspecific variation both in morphometrics and molecular data sets. The endemic South American Histiotus bats, currently considered a subgenus of Eptesicus, har

The article maps the pitfalls and affordances of automatic speech recognition in the study of audiovisual media and digital history more broadly. Three key topics are emphasized: first, the collaboration between scholars and audiovisual archives and the potential of automatic speech recognition to transform the way scholars navigate and engage with audiovisual media history; second, what knowledge

Biografisk artikel om latinaren, läroverksläraren, professorn, ordensgrundaren m m Carl Magnus Zander (1845-1923).

Understanding the link between titanium-aluminium nitride's (Ti1-xAlxN) physicochemical properties and structural dynamics during operation is essential to designing and fabricating advanced ceramic coatings. Here, we directly visualise the oxidation of Ti1-xAlxN (for x = 0, 0.18, 0.44, & 0.67) coatings from 100 to 1000 °C using environmental transmission electron microscopy (ETEM) imaging and

Selected high resolution axial images obtained from a 7T MRI scanner have been labeled to provide detailed information about the subtle structures found in the cerebellum and brainstem.

This review addresses tilt-testing methodology by searching the literature which reports timing of asystole and loss of consciousness (LOC). Despite the Italian protocol being the most widely adopted, its stipulations are not always followed to the letter of the European Society of Cardiology guidelines. The discrepancies permit reassessment of the incidence of asystole when tilt-down is early, im

BACKGROUND AND AIMS: Whether non-alcoholic fatty liver disease (NAFLD) is a cardiovascular (CV) risk factor is debated. We performed a systematic review and meta-analysis to assess the CV morbidity and mortality related to NAFLD in the general population, and to determine whether CV risk is comparable between lean and non-lean NAFLD phenotypes.METHODS AND RESULTS: We searched multiple databases, i

A distinguishing feature of youth detention homes—and any other prisonlike institution—is the fact that inmates cannot just leave. They might escape, and there are ways to be transferred, enjoy an excursion, and get permission for home visits, but typically the young people in this case are supposed to remain within their given institution. I have been eager to not only depict this feature of fielA distinguishing feature of youth detention homes—and any other prisonlike institution—is the fact that inmates cannot just leave. They might escape, and there are ways to be transferred, enjoy an excursion, and get permission for home visits, but typically the young people in this case are supposed to remain within their given institution. I have been eager to not only depict this feature of fiel

In this presentation I discussed the method for data collection that I was about to perform after the conference had taken place. Limitations and risks were discussed.

Due to high demand and capacity consumption, railway timetables are often sensitive to disturbances. To maintain punctual operations, it is important that timetables are robust, and methods are needed that make them robust without consuming too much capacity. In this paper, we demonstrate how a policy change in the form of new timetable planning rules can be used to achieve more robust timetables.