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Cueing and construing dialogue in English and Spanish

This study explores the ways in which English and Spanish direct speech is portrayed through the verbs in Speech Framing Expressions (SFEs) introducing dialogues. The descriptive purpose is to identify what verb meanings are used to cue direct speech in SFEs, what lexical resources there are to express these meanings, how the meanings are lexicalized and how rich the vocabularies are. Five main se

The intersubjective role of I think constructions in conversation : Combining evidence from corpus and experimental techniques

Combining data from spontaneous face-to-face conversations in the London-Lund Corpus (LLC) of spoken British English and a laboratory experiment, this paper analyses the dynamic nature of I think constructions in dialogue. We make use of the functional category of ENGAGEMENT in APPRAISAL theory as an analytical tool (Martin & White, 2005). More precisely, we examine whether I think constructio

Sociolinguistic Features for Author Gender Identification : From Qualitative Evidence to Quantitative Analysis

Theoretical and empirical studies prove the strong relationship between social factors and the individual linguistic attitudes. Different social categories, such as gender, age, education, profession and social status, are strongly related with the linguistic diversity of people’s everyday spoken and written interaction. In this paper, sociolinguistic studies addressed to gender differentiation ar

C4b-binding protein protects β-cells from islet amyloid polypeptide-induced cytotoxicity

C4BP (C4b-binding protein) is a polymer of seven identical α chains and one unique β chain synthesized in liver and pancreas. We showed previously that C4BP enhances islet amyloid polypeptide (IAPP) fibril formation in vitro. Now we report that polymeric C4BP strongly inhibited lysis of human erythrocytes incubated with monomeric IAPP, whereas no lysis was observed after incubation with preformed

Mentally disordered offenders in Sweden : differentiating recidivists fromnon-recidivists in a 10-year follow-up study

Background: Forensic psychiatric patients present a challenge as they manifest severe mental disorders together with criminal behaviour. There are well-known risk factors for criminal behaviour in the general population, yet knowledge of what predicts reconviction in the Swedish forensic population in the long-term perspective is still insufficient. Aims: The study aims to (1) describe background

Conflict between the Electronic Factors and Structure-Directing Rules in the Intergrowth Structure of Ca4Ag2+xGe4-x with x = 1/2

Combined experimental and theoretical efforts to conceptually understand the structure directing forces in intergrowth structures have led to the discovery of the new ternary phase Ca4Ag2+xGe4-x (x = 0.5), obtained from high-temperature reaction of the elements. It crystallizes in a new structure type according to single-crystal diffraction methods: monoclinic space group C2/m-i10 with a = 10.7516

Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia

Males of all species of the parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pheromone while only N. vitripennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR). Three genes coding for the NAD + -dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV10128, and NV10129 are linked to the ability of Nv to produce RR. Here we sho

Aspects of prophylactic treatment of hemophilia

Retrospective and prospective studies unambiguously show that prophylactic treatment of severe hemophilia A or B should be started as primary prophylaxis at 1-2 years' of age and ideally before the first joint bleed. The dose and dose frequency should be individually tailored depending on the goal of treatment, venous access and the bleeding phenotype. The circumstances during the first exposures

Integrated Acoustic Separation, Enrichment, and Microchip Polymerase Chain Reaction Detection of Bacteria from Blood for Rapid Sepsis Diagnostics

This paper describes an integrated microsystem for rapid separation, enrichment, and detection of bacteria from blood, addressing the unmet clinical need for rapid sepsis diagnostics. The blood sample is first processed in an acoustophoresis chip, where red blood cells are focused to the center of the channel by an acoustic standing wave and sequentially removed. The bacteria-containing plasma pro

Assessing the external validity of algorithms to estimate EQ-5D-3L from the WOMAC

Background: The use of mapping algorithms have been suggested as a solution to predict health utilities when no preference-based measure is included in the study. However, validity and predictive performance of these algorithms are highly variable and hence assessing the accuracy and validity of algorithms before use them in a new setting is of importance. The aim of the current study was to asses

Consistent assimilation of multiple data streams in a carbon cycle data assimilation system

Data assimilation methods provide a rigorous statistical framework for constraining parametric uncertainty in land surface models (LSMs), which in turn helps to improve their predictive capability and to identify areas in which the representation of physical processes is inadequate. The increase in the number of available datasets in recent years allows us to address different aspects of the model

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

Integrins are heterodimeric transmembrane proteins that play a fundamental role in the migration of leukocytes to sites of infection or injury. We found that protein tyrosine phosphatase nonreceptor type 22 (PTPN22) inhibits signaling by the integrin lymphocyte function-associated antigen-1 (LFA-1) in effector T cells. PTPN22 colocalized with its substrates at the leading edge of cells migrating o

Individualized prediction of lung-function decline in chronic obstructive pulmonary disease

Background: The rate of lung-function decline in chronic obstructive pulmonary disease (COPD) varies substantially among individuals. We sought to develop and validate an individualized prediction model for forced expiratory volume at 1 second (FEV1) in current smokers with mild-to-moderate COPD. Methods: Using data from a large long-term clinical trial (the Lung Health Study), we derived mixed-ef

Opioid and amphetamine dependence is associated with methicillin-resistant Staphylococcus aureus (MRSA) : An epidemiological register study with 73,201 Swedish in- and outpatients 1997–2013

Background: While methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence globally, Sweden is still a low-prevalence country enabling studies on the natural MRSA spread in subpopulations unaffected by a surrounding highly infected population. Substance dependence and injection drug use have been risk factors for MRSA carriage and infection in other countries. In this retrosp

Comparison of a web-based food record tool and a food-frequency questionnaire and objective validation using the doubly labelled water technique in a Swedish middle-aged population

Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report

Moder Elisabeth Hesselblad : Ett svenskt helgon i takt med tiden

Den 5 juni 2016 helgonförklarades Maria Elisabeth Hesselblad (1870-1957), grundarinnan av den romerska grenen av birgittinorden. Hon är det andra svenska helgonet efter heliga Birgitta som kanoniserats av påven. Intressant nog har hon återupprättat just den ordensgemenskap som går tillbaka på heliga Birgitta, om än i ny form. I artikeln presenteras Hesselblad och hennes verk och hur bilden av henn

UHV and Ambient Pressure XPS : Potentials for Mg, MgO, and Mg(OH)2 Surface Analysis

The surface sensitivity of x-ray photoelectron spectroscopy (XPS) has positioned the technique as a routine analysis tool for chemical and electronic structure information. Samples ranging from ideal model systems to industrial materials can be analyzed. Instrumentational developments in the past two decades have popularized ambient pressure XPS, with pressures in the tens of mbar now commonplace.

The rate of brain death and organ donation in patients resuscitated from cardiac arrest : a systematic review and meta-analysis

Background: The occurrence of brain death in patients with hypoxic-ischaemic brain injury after resuscitation from cardiac arrest creates opportunities for organ donation. However, its prevalence is currently unknown. Methods: Systematic review. MEDLINE via PubMed, ISI Web of Science and the Cochrane Database of Systematic Reviews were searched for eligible studies (2002–2016). The prevalence of b