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A Thromboelastometric Evaluation of the Effects of Hypothermia on the Coagulation System

BACKGROUND: Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated wh

An Empirical Analysis of Factors Driving the Swap Spread

In this article, we perform a robust analysis of the determinants of U.S. swap spreads using a wide range of theoretically motivated candidate factors. We conduct an analysis by taking into consideration the interdependence between the candidate factors, as well as the time frequency under which the factors affect the spread. We find that the suggested variables can to a fair degree explain moveme

The role of harvesting in age-structured populations: Disentangling dynamic and age truncation effects

Understanding the processes generating fluctuations of natural populations lies at the very heart of academic ecology. It is also very important for applications such as fisheries management and pest control. We are interested in the effect of harvesting on population fluctuations and for that purpose we develop and analyze an age-structured model where recruitment is a stochastic process and the

Everyday Evidence: Outcomes of Psychotherapies in Swedish Public Health Services

This naturalistic study presents outcomes for three therapy types practiced in psychiatric public health care in Sweden. Data were collected over a 3-year period at 13 outpatient psychiatric care services participating in the online Quality Assurance of Psychotherapy in Sweden (OAPS) system. Of the 1,498 registered patients, 14% never started psychotherapy, 17% dropped out from treatment, and 36%

Influencing teaching and learning microcultures. Academic development in a research-intensive university.

Popular Abstract in Swedish Alltsedan expansionen av den högre utbildningen tog fart i Sverige, i slutet av 60-talet, har universitet och högskolor arbetat för att utveckla utbildningskvaliteten. Detta har bland annat gjorts genom satsningar på policys som reglerar exempelvis arbete med kursvärderingar, mångfald, och kurs- och utbildningsplaner. Satsningar har också gjorts på pedagogisk utbildningThe focus in this thesis is to explore theoretical perspectives and strategies for academic development, particularly in a research-intensive university. The purpose is to investigate academic development that aims to support and influence individual academic teachers and groups of teachers, in the different social collegial contexts that they work in, here called microcultures. Building on litera

Bioavailability of DOC in leachates, soil matrix solutions and soil water extracts from beech forest floors

The biodegradability of dissolved organic carbon (DOC) in different fractions from the forest floor was studied. Soil leachate (SI, the soil solution in macropores which is freely drained from forest floor after rainfall), the soil matrix solution (SMS, the soil solution in meso-/micropores of the soil matrix), and soil water extracts (SWE) from two different beech forest floors were compared. Zer

Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells

Inflammation is a response to injury or pathogen invasion. A large proportion of the bodie's immune system is centred in the gastrointestinal tract (GI). Prolonged inflammatory conditions of the GI have been suggested to increase the risk for developing colon cancer. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known receptors, two of wh

Application of a district management approach to Southern African river basin systems: the case of the Umbeluzi, Incomati and Maputo river basins

In recent years, the 'river basin as a management unit' approach has been adopted as a solution to water management. The situation between Swaziland, Mozambique and South Africa regarding managing the water resources of the Incomati, Maputo, and Umbeluzi shared river basins is an interesting case that might need a different approach. These rivers flow downstream to the Maputo estuary where their w

A hypothesis for Proterozoic-Phanerozoic supercontinent cyclicity, with implications for mantle convection, plate tectonics and Earth system evolution

We present a conceptual model for supercontinent cycles in the Proterozoic-Phanerozoic Eons. It is based on the repetitive behavior of C and Sr isotopes in marine carbonates and U–Pb ages and εHf of detrital zircons seen during the Neoproterozoic-Paleozoic and Paleoproterozoic Eras, respectively. These records are considered to reflect secular changes in global tectonics, and it is hypothesized th

Socioeconomic patterns of overweight and obesity in Scania, Sweden

Popular Abstract in Swedish Socioekonomiska mönster av övervikt och fetma i Skåne, Sverige I världen idag är fetma och övervikt ett av de största hoten mot människors goda hälsa. Den här avhandlingen har försökt beskriva och öka kunskapen om hur olika faktorer, som levnadsvillkor och levnadsvanor, bidragit till ökningen av övervikt och fetma i befolkningen. Övervikt och fetma ökar risken för en rOverweight and obesity are major social and public health concerns globally. The obesity epidemic is caused by a widespread chronic energy imbalance between high-energy intake and low-energy expenditure, but this mechanism appears to be modified by a number of other biological, behavioral, and social factors that interact in a complicated manner. It has become a great challenge to understand the e

Participation in physical activities and sedentary behaviour among children with physical disabilities

Participating in physical activity promotes physical and mental health. Children with physical disabilities are not as physically active as other children. They tend to participate in lower intensity physical activity, choose more passive activities with less variety and have more sedentary time. The overall aim of this thesis was to gain knowledge about participation in physical activities, to i

The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions

Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that have the required functional diversity. Thus the different activities displayed by these proteins are mediated by spatially distinct domains, consistent with the specific chemical requirements of each activity. Indeed, current evolutionary theo

Retinoic Acid Is Involved in the Metamorphosis of the Anal Fin into an Intromittent Organ, the Gonopodium, in the Green Swordtail (Xiphophorus hellerii).

In poeciliid fish the male anal fin has been transformed into a gonopodium, an intromittent organ required for internal fertilization. Elevated testosterone levels induce metamorphosis of a subset of anal fin rays to grow and form the specialized terminal structures of the gonopodium. The molecular mechanisms underlying these processes are largely unknown. Here, we investigated whether retinoic ac

Application of a dye-binding method for the determination of available lysine in skim milk powders.

A dye-binding method using Acid Orange 12 was investigated regarding its suitability for the quantification of available lysine, as a means of monitoring the Maillard reaction in skim milk powders. The method was evaluated by analyzing a wide range of milk powders produced by three different drying methods and stored under various conditions. A pilot-scale freeze-dryer, spray-dryer and drum-dryer

Evaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data.

Myocardial perfusion scintigraphy (MPS) is a clinically useful noninvasive imaging modality for diagnosing patients with suspected coronary artery disease. By utilizing gated MPS, the end diastolic volume (EDV) and end systolic volume (ESV) can be measured and the ejection fraction (EF) calculated, which gives incremental prognostic value compared with assessment of perfusion only. The aim of this

Ecological Implications of Changes in the Arctic Cryosphere

Snow, water, ice, and permafrost are showing evidence of substantial change in the Arctic, with large variations among different geographical areas. As a result of these changes, some habitats and their associated ecosystems are expanding, while others are undergoing rapid contraction. The warming of the Arctic cryosphere is limiting the range for cold-adapted biota, and less specialized taxa incl