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Glial cell line-derived neurotrophic factor (GDNF) has shown potential as a treatment for Parkinson's disease. Recombinant adeno-associated viral vectors expressing the GDNF protein (rAAV-GDNF) have been used in rodent models of Parkinson's disease to promote functional regeneration after 6-OHDA lesions of the nigrostriatal system. The goal of the present study was to assess the anatomical and fun

In order to maximize protein identification by peptide mass fingerprinting noise peaks must be removed from spectra and recalibration is often required. The preprocessing of the spectra before database searching is essential but is time-consuming. Nevertheless, the optimal database search parameters often vary over a batch of samples. For high-throughput protein identification, these factors shoul

Antimony-vanadium-oxide catalysts were prepared with various Sb/V ratios and were used for propene ammoxidation. It was observed that antimony in excess of the amount required for forming SbVO4 was required to have a catalyst that is selective to acrylonitrile formation. Characterisation of catalysts with FTIR revealed partial reduction of the oxidised phase Sb0.92V0.92O4 upon use to form Sb0.95V1

The radiological findings in six patients fulfilling the criteria of neurofibromatosis type 2 (NF2) were reviewed. Subtle cutaneous lesions were found in three. All patients had bilateral acoustic schwannomas; two had small acoustic tumours and normal hearing. In these patients the presenting symptoms were caused by multiple intracranial meningiomas and spinal neurofibromas, respectively, whereas

An implementation of triples corrections for the calculation of the electronic ground states and for singlet and triplet excitation energies within the CC3 model is discussed. At most objects of size (VO2)-O-2 and (VO)-O-3 are kept in memory and on disc, respectively (V is the number of virtual orbital and O is the number of occupied orbitals). The used strategy means that more terms that scales a

Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathologi

PURPOSE: To determine whether long-term treatment with the anti-epileptic drug vigabatrin causes damage to rabbit retina.METHODS: Five rabbits were treated continuously with a daily dose of vigabatrin solution per orally during a period of 1-8 months. Two rabbits receiving water were used as controls. Repeated full-field electroretinograms (every two weeks) were assessed during this period. Vigaba

The proposed Differential Difference Comparator (DDC) provides easy linear voltage summing/subtraction and comparison functions via current operation. The speed of this unconventional comparator drastically improved since there is no feedback loop and coupling capacitors needed to maintain the linearity. The linear input range is also enlarged by the common mode compression. The principle, design

We consider gamma-ray bursts (GRBs) produced by the merger of a massive white dwarf with a neutron star. We show that these are likely to produce long-duration GRBs, in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation, and occur close to the host galaxy. However, rare members of the class need not

Malacoplakia is a granulomatous disease with a histiocytic infiltrate containing calcified structures called Michaelis-Gutmann bodies. These structures are considered to represent an abnormal response to infection involving defective lysosomes and abnormal microbubular assembly. The disease most frequently involves urinary and genital tracts, but has also been described from most other organs. Her

Chronic diseases (CD) represent the main cause of mortality in developed countries. The increase in the prevalence of of CD is associated with changes in lifestyle habits, including those related to the consumption of processed foodstuffs. In these foods advanced glycation end products (AGE) and advanced lipoperoxydation products (ALE) are formed as a consequence of the reactivity of proteins, car

Scheelite CdMoO4 and wolframite eCdWO(4):MO (0.04-0.4wt%) single crystals were studied using the time-resolved spectroscopy under UV excitation over a temperature range of 1.85-300K. The threshold energies for the creation of free charge carriers were measured using the method of photostimulated luminescence. The decay kinetics of the main emission in CdMoO4 and the molybdenum-related emission in

The importance of different sources of gases in a vacuum system is discussed and the definitions of different flow regimes are presented. The conductance is given for a few different, typical geometries in an accelerator vacuum system. The theory is applied to the vacuum system of the Lund electrostatic tandem accelerator and a pressure profile through the accelerator is calculated. The quality of

By comparison of the cDNA-derived amino acid sequences and the cell type-specific patterns of synthesis we have identified desmocollin Dsc2 as the most widespread, perhaps ubiquitous desmocollin subtype. Using Northern blot analyses and ribonuclease protection assays we have found an approximately 5.6 kb mRNA encoding Dsc2 in all the diverse human tissues, tumors and cell lines examined that are k

A formula of Walczak is applied to two situations in differential geometry. Holomorphic distributions on Kahler manifolds are studied, and it is shown how the formula simplifies to a Bochner type formula, which is particularly useful in the study of integrable distributions. Then the Walczak formula is applied in the context of harmonic morphisms, where it provides a means of investigating the ver

Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood. Herein, we studied ERK activation in response to two laminins isoforms (-1 and -10/11) in two epithelial cell lines. Both cell lines expressed {beta}1-containing integrins and dystroglycan but lacked integrin {alpha}6{beta}4. Antibody pertu

In this work, the effect of composition, particle size and particle size ratio on the tensile properties of well-characterized hard/soft latex blends was investigated. Four blends of hard/soft latices, with varying particle sizes (either small or large), and volume fractions of 100/0, 80/20, 60/40, 50/50, 40/60, 20/80 and 0/100 were studied. The stress at break increased and the strain at break de