Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biologic responses. Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear. Methods: CD-1 mice were administered different PI3K inhibitors either intranasally or intragastrically once a day for

What happens when cultural analysis enters the world of applied research and academics become consultants working with corporations and public institutions? The divide between academic research and commercial ethnography has often hampered communication and critical exchanges between these two worlds. In this paper we look at the experiences of consultants, drawing on Danish and Swedish examples.

Sammandrag. Uppsatsen är en studie av syntaktiska, semantiska och pragmatiska egenskaper hos konstruktionen x-som-x. Undersökningen tar sin utgångspunkt i den interaktionella grammatiken, och som jämförelsematerial används tidigare undersökningar av konstruktionen x-och-x. Exempel på x-som-x är hämtade från olika källor på Internet, såsom bloggar och diskussionsforum. I avsnittet om konstruktionen

Background: Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was to investigate the influence of polyamine pool reduction on the cytotoxic effe

We present a method aimed at reducing uncertainties and instabilities when characterizing materials in waveguide setups. The S-parameters for a rectangular waveguide loaded with a rectangular sample block are measured for three different sample orientations, and the corresponding geometries are modeled in a finite element program, taking any material parameters as input. The material parameters of

We present a detailed experimental and numerical study of the structural and dynamical properties of salt-free lysozyme solutions. In particular, by combining small-angle X-ray scattering (SAXS) data with neutron spin echo (NSE) and rheology experiments, we are able to identify that an arrest transition takes place at intermediate densities, driven by the slowing down of the cluster motion. Using

Klädgalgen är en relativt sentida företeelse i de svenska hemmen. Artikeln diskuterar galgen såsom "massprodukt" men också dess, i många fall, mycket säregna, rentav unika, utformning och estetik. Artikeln vill lyfta fram att galgen, ett obetydligt och ofta undangömt föremål, inte sällan har ägnats en stor omtanke. Vissa galgar är helt unika. Även ett enkelt vardagsföremål, såsom en galge, uttryck

We previously demonstrated that the overall incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP1) are increased in insulin-resistant mice and may contribute to the upregulated β-cell function. Now we examined whether this could, first, be explained by increased islet GLP1 receptor (GLP1R) protein levels and, secondly, be leveraged by G-protein-coupled receptor 119 (GPR119

Background: In the everyday surgical life, staff may experience that patients with Alcohol Use Disorders (AUDs) seem reluctant to participate in alcohol intervention programs. The objective was therefore to assess acceptance of screening and intervention as well as adherence to the intervention program among emergency department (ED) and surgical patients with AUDs. Methods: A systematic literatur

Granular sands are characterized and modeled here by explicitly exploiting the discrete-continuum duality of granular matter. Grain-scale kinematics, obtained by shearing a sample under triaxial compression, are coupled with a recently proposed multiscale computational framework to model the behavior of the material without resorting to phenomenological evolution (hardening) laws. By doing this, c

Collection and recycling systems for small waste electrical and electronic equipment (WEEE) in Europe has been developed based on the 2003 EU Directive on Waste Electrical and Electronic Equipment (WEEE Directive), which was transposed into the national laws of EU Member States. With the growing recognition on the potential for small WEEE to supply mateirals that are critical to the continued grow

White horses frequently suffer from malign skin cancer and visual deficiencies owing to their high sensitivity to the ultraviolet solar radiation. Furthermore, in the wild, white horses suffer a larger predation risk than dark individuals because they can more easily be detected. In spite of their greater vulnerability, white horses have been highly appreciated for centuries owing to their natural

Intradialytic hypotension is the most common acute complication during conventional hemodialysis treatment. Prediction of such events is highly desirable in clinical routine for prevention. This paper presents a novel prediction method of acute symptomatic hypotension in which the photoplethysmographic signal is analyzed with respect to changes in amplitude, reflecting vasoconstriction, and cardia

There is empirical evidence indicating that trust in research is decreasing. If distrust is justified, this is a good thing; if not, it is a cause of concern. A basic question concerns the reasons for, ant the causes of, distrust. Which are they, what do they mean, and how reliable are they? The papers and presentations in this volume focus on external and internal factors contributing to distrus

Background: It is not known whether the recently described break in the trend in hip fracture incidence in many settings applies in both women and men, depends on changes in bone mineral density (BMD) or changes in other risk factors, or whether it is apparent in both urban and rural settings. Methods: We evaluated changes in annual hip fracture incidence from 1987 to 2002 in Swedish men aged >= 6

The principal results of project 440 "Assembly and Breakup of Rodinia" of the International Geological Correlation Programme (IGCP) are reviewed in this work. A map of that supercontinent compiled using geological and paleomagnetic data describes global paleogeography 900 Ma ago. The assembly of Rodinia, which comprised most of Precambrian continental blocks, lasted ca. 400 m.y. (from 1300 to 900