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Evidence that the galectin family of proteins plays crucial roles in cancer, inflammation, and immunity has accumulated over the last decade. The galectins have consequently emerged as interesting drug targets. A majority of galectin functions occurs by means of cross-linking glycoproteins and by doing so controlling gly-coproteirl cellular localization and residence times. The glycoprotein cross-
Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson's disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown. In this study, we use modified rabies virus to trace afferent and efferent connectivity of transplan
Approximately 470 million years ago one of the largest cosmic catastrophes occurred in our solar system since the accretion of the planets. A 200-km large asteroid was disrupted by a collision in the Main Asteroid Belt, which spawned fragments into Earth crossing orbits. This had tremendous consequences for the meteorite production and cratering rate during several millions of years following the
Metabolite profiling was used to characterize stress responses of potato tissue subjected to reversible electroporation, providing insights on how potato tissue responds to a physical stimulus such as pulsed electric fields (PEF), which is an artificial stress. Wounded potato tissue was subjected to field strengths ranging from 200 to 400 V/cm, with a single rectangular pulse of 1 ms. Electroporat
Photoreceptor degeneration in retinitis pigmentosa is one of the leading causes of hereditary blindness in the developed world. Although causative genetic mutations have been elucidated in many cases, the underlying neuronal degeneration mechanisms are still unknown. Here, we show that activation of cGMP-dependent protein kinase (PKG) hallmarks photoreceptor degeneration in rd1 and rd2 human homol
Nitrogen and oxygen K emission spectra of glycine in the form of anions, zwitterions, and cations in aqueous solution are presented. It is shown that protonation has a dramatic influence on the local electronic structure and that the functional groups give a distinct spectral fingerprint.
In this paper, we report on the development of a vertical wrap-gated field-effect transistor based on epitaxially grown InAs nanowires. We discuss some of the important steps involved in the growth and processing, such as nanowire position control in situ doping, high-kappa dielectric deposition, spacer layer formation: and metal wrap-gate fabrication. In particular, we compare a few alternative m
Popular Abstract in Swedish Ortnamn utgör en särskild del av kulturarvet; under århundraden har de muntligen traderats från generation till generation på den plats där de skapats, där de minner om tidigare händelser, aktiviteter och kunskaper. I synnerhet på de håll skriftlig dokumentation är relativt sentida ger ortnamn en möjlighet att nå insikter om den mer avlägsna historien. Detta gäller särsAs a special part of our cultural heritage, toponyms have been handed down orally from generation to generation for centuries or more at the place where they were coined, recalling events, activities and knowledge. Especially where written documentation is relatively young, place names offer a way to reach further back into the past. This is particularly true of many dialectal cultures, in which o
A new two-state polymer folding model is proposed, in which the folding of a stiff helical polymer is enabled by allowing for short sequences of coils connecting shorter and separated helices. The folding is driven by short-range attraction energy among stacked helices and is opposed by the free-energy cost of forming coils from helical monomers. Principal outcomes of the model are equilibrium dis
Photo-Fenton oxidation was used for treatment of synthetic textile wastewater as stand alone treatment, as pre-treatment before aerobic biological treatment and as post-treatment after anaerobic biological treatment. The processes were compared with regards to decolorization, chemical oxygen demand (COD) reduction and chemical consumption. When applying photo-Fenton alone for treatment of Remazol
The detailed structural and mechanical properties of a tetraoleoyl cardiolipin (TOCL) bilayer were determined using neutron spin echo (NSE) spectroscopy, small angle neutron and X-ray scattering (SANS and SAXS, respectively), and molecular dynamics (MD) simulations. We used MD simulations to develop a scattering density profile (SDP) model, which was then utilized to jointly refine SANS and SAXS d
An evacuation experiment including 100 individuals was performed inside a tunnel in order to study the effectiveness of different way-finding installations and to collect data on movement speeds and human behaviour. The participants took part in the experiment individually, and no group interactions were studied. The experiment tunnel was 200 m long and an emergency exit was located 180 m into the
Popular Abstract in Swedish Avhandlingen diskuterar Sociologins position i debatten kring artificiell intelligens, d.v.s sådan AI som kan skapa kunskap på egen hand. Det påpekas att sociologin behöver göra en åtskillnad mellan två sätt att skapa AI system: Symbolisk AI (eller Klassisk AI) och Distribuerad AI – DAI. Den sociologiska litteraturen visar en i stort kritisk attityd till symbolisk AI viThis dissertation is concerned with Sociology’s stance in the debate on Strong Artificial Intelligence, i.e. such AI that is able to shape new knowledge without human interference. There is a need for sociologists to realize the difference between two approaches to constructing AI systems: Symbolic AI (or Classic AI) and Distributed AI – DAI. Sociological literature shows a largely critical attitu
We demonstrate that freeing a single-atom thick layer of hexagonal boron nitride (h-BN) from tight chemical bonding to a Ni(111) thin film grown on a W(110) substrate can be achieved by intercalation of Au atoms into the interface. This process has been systematically investigated using angle-resolved photoemission spectroscopy, x-ray photoemission, and absorption techniques. It has been demonstra
Security of supply is widely addressed in the academia. In this paper we conduct a review of methodologies, discuss strengths and weaknesses and identify areas that would benefit from further research and methodology development. A distinction is made between methodologies used to assess general vulnerability and those that value the outcome of insecurity by testing how energy systems respond to d
Popular Abstract in Swedish Under 1900-talets inledande decennier genomfördes fältarbeten på den svenska landsbygden då äldre bebyggelse och byar dokumenterades på bild och i ord. Dessa dokumentationer ingick i ett större sammanhang, där ambitionen var att alla aspekter av en förmodat försvinnande allmogekultur skulle kartläggas, samlas in och arkiveras. By- och bebyggelsedokumentationerna utfördeIn the first decades of the twentieth century there were fieldwork expeditions in rural Sweden, documenting archaic buildings and villages in words and pictures. These documentation efforts were part of a larger context, where the ambition was to survey and collect all aspects of what was presumed to be a vanishing peasant culture. The documentation was carried out by several different museums and
