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Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt at their 3' end, and moreover that the 3' end of miR-21 is po

BACKGROUND: Few large-scale studies have examined the association between sociodemographic factors and the probability of reaching the recommended levels of HbA1c and blood lipids in patients with type 2 diabetes. The aim was to investigate whether sociodemographic characteristics of type 2 diabetes patients affected the odds that they would reach recommended levels of blood lipids and HbA1c. METH

During the last 20 years, several regions in Central America and Mexico have seen a dramatic increase of a rapidly progressive chronic kidney disease, unexplained by diabetes and hypertension.(1-3) This regional epidemic of chronic kidney disease of unknown origin (CKDu) is also being referred to as the Mesoamerican nephropathy or MeN.(4) It has been estimated that this largely unknown epidemic ha

To develop methods for qualitative and quantitative evaluation of MRI artifacts near metallic prostheses, and to compare the efficiency of different artifact suppression techniques with different types of hip prostheses.

Survival after non-Hodgkin lymphoma (NHL) has increased thanks to improved treatment but NHL survivors have an increased risk of second neoplasms. The assessment of cancer risk patterns after NHL may help to quantify the late side-effects of therapy. Poisson regression was used to estimate relative risks (RRs) and absolute incidence rates for nine solid tumours based on a nationwide cohort of 60 9

We generalize the traditional concept of single-peaked preference domains in two ways. First, we introduce the concept of a multiple single-peaked domain, where the set of alternatives is equipped with several underlying orderings with respect to which a preference can be single-peaked, and we argue that these domains are appropriate to represent preferences over political parties. Second, we defi

A micellar nanocontainer delivery and release system is designed on the basis of a peptide-polymer conjugate. The hybrid molecules self-assemble into micelles comprising a modified amyloid peptide core surrounded by a PEG corona. The modified amyloid peptide previously studied in our group forms helical ribbons based on a beta-sheet motif and contains beta-amino acids that are excluded from the be

Pollen and spore analysis is the most successfully used palaeobotanical discipline for reconstructing Holocene vegetation and climate history throughout the world. Subantarctic islands are very specific areas. They are located in the circum-Antarctic Southern Ocean in latitudes that are under strong influence of the southern westerly winds, and are characterised by a treeless, phanerogam-poor flor

"Inflammation resolution" has of late become a topical research area. Activation of resolution phase mechanisms, involving select post-transcriptional regulons, transcription factors, 'autacoids', and cell phenotypes, is now considered to resolve inflammatory diseases. Critical to this discourse on resolution is the elimination of inflammatory cells through apoptosis and phagocytosis. For major in

Study Type - Prognosis inception (cohort) Level of Evidence 2 What's known on the subject? and What does the study add? There are two randomized controlled trials showing that radiotherapy can be beneficial for men with locally advanced prostate cancer. The present study confirms the importance of curative treatment for men with high-risk prostate cancer. OBJECTIVE: • To investigate the influen

A majority of the established systems for determination and optimization of cutting data are based on Woxén’s equivalent chip thickness, heW. In metal cutting theory and models, the equivalent chip thickness is of vital importance when the depth-of-cut ap is in the same order or smaller than the nose radius r. Woxén made considerable simplifications in his chip area model, that form the basis for

Through rapid reactions with ozone, which can initiate the formation of secondary organic aerosols, the emission of sesquiterpenes from vegetation in Amazonia may have significant impacts on tropospheric chemistry and climate. Little is known, however, about sesquiterpene emissions, transport, and chemistry within plant canopies owing to analytical difficulties stemming from very low ambient conce

We previously presented evidence that transmembrane domain (TM) IV and TM X-XI are important for inhibitor binding and ion transport by the human Na+/H+ exchanger, hNHE1 (Pedersen, S. F., King, S. A., Nygaard, E. B., Rigor, R. R., and Cala, P. M. (2007) J. Biol. Chem. 282, 19716-19727). Here, we present a structural model of the transmembrane part of hNHE1 that further supports this conclusion. Th

The use of intravenous artificial oxytocin for augmentation of labour is very common in midwifery care in Sweden. Studies have shown that oxytocin is often administered to women in labour who have no signs of labour dystocia. It was the aim of this study to examine Swedish midwives' views on and experiences of labour augmentation in the context of normal labour. Individual interviews were carried

The physical office environment has been shown to be associated with indicators of both health and performance. This study focuses on how memory performance is affected in normal working conditions compared to a quiet baseline (with low amount irrelevant stimuli) in different office types, including individual office rooms, small open-plan offices, medium-sized open-plan offices and large open-pla

The oxidation of sulfite to sulfate by two different models of the active site of sulfite oxidase has been studied. Both protonated and deprotonated substrates were tested. Geometries were optimized with density functional theory (TPSS/def2-SV(P)) and energies were calculated either with hybrid functionals and large basis sets (B3LYP/def2-TZVPD) including corrections for dispersion, solvation, and

Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix, which mainly develops at the squamocolumnar (SC) junction. The progression of cervical HPV infections into (pre)neoplastic lesions suggests that viral antigens are not adequately recognized by innate immunity or presented to the adaptive immune system. Members of the defensin famil

The agro-climatic resources of Cameroon are examined in light of the potential for food crop production and challenges presented by climate change. We find that the diversity of Cameroon's agro-climate offers the potential for the cultivation of a variety of food crops. This feature of Cameroonian agriculture can be used in addressing the country's adaptive capacity to climate change. However, the

The aim of this article is to introduce a meta-theoretical discussion in architectural research about materiality and its effect on everyday life and use. Taking a relational perspective, I distinguish between three different perspectives on materialities as described in theories in recent decades. From these perspectives I develop three possible conceptualisations of interobjectivity. The first p