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AuCd4: A Hume-Rothery Phase with VEC of 1.8 and Icosahedral and Trigonal-Prismatic Clusters as Building Blocks.

The η phase in the Au-Cd binary system has been synthesized, and the structure has been analyzed by single-crystal X-ray diffraction. The compound η-AuCd4 crystallizes in the hexagonal space group P63/m (No. 176). The unit cell contains ∼273 atoms. The compound AuCd4 represents a √3a × √3a × c superstructure of the AgMg4 type. The structure can be well described by icosahedral and trigonal-prismat

Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants

The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being re

HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts.

During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen shortage. HIFs are also implicated in the progression of several cancer forms, and hig

On the secondary flow through bifurcating pipes

The secondary motion induced by flow through curves and bifurcations has been subject to investigation over long time due to its importance in physiological and technological applications. In contrast to the flow in a straight pipe, curvature leads to the formation of secondary flow which is often unsteady. Streamline curvature occurs also in bifurcating pipes leading to some corresponding seconda

Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.

Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissi

A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix (R) in subjects aged 11-17 years: An open, randomised, controlled trial

The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both

Characterization of Bioethanol Production from Hexoses and Xylose by the White Rot Fungus Trametes versicolor

Bioethanol production by white rot fungus (Trametes versicolor), identified from fungal mixture in naturally decomposing wood samples, from hexoses and xylose was characterized. Results showed that T. versicolor can grow in culture, under hypoxic conditions, with various mixtures of hexoses and xylose and only xylose. Xylose was efficiently fermented to ethanol in media containing mixtures of hexo

Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability

Microalbuminuria is an established marker of systemic endothelial dysfunction, which for patients with diabetes signals an increased risk of both diabetic nephropathy and cardiovascular complications. A better understanding of the pathogenesis of microalbuminuria is important in the quest of finding new approaches to treat patients with diabetes. Direct acute effects of episodes of hyperglycaemia

SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.

Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal tract. Special AT-rich sequence binding protein 1 (SATB1) is a global genome organizer that has been de

Phase II Study of the Human Anti-Epithelial Cell Adhesion Molecule Antibody Adecatumumab in Prostate Cancer Patients with Increasing Serum Levels of Prostate-Specific Antigen after Radical Prostatectomy

Background: Rising serum levels of prostate-specific antigen (PSA) after radical prostatectomy are indicative of recurrent prostate cancer. This double-blind, placebo-controlled phase II study evaluated the anti-tumour activity of the anti-epithelial cell adhesion molecule (EpCAM) antibody adecatumumab in delaying biochemical disease progression. Patients and Methods: Prostate cancer patients with

Effective dose from chest tomosynthesis in children.

Tomosynthesis (digital tomography) is a recently introduced low-dose alternative to CT in the evaluation of the lungs in patients with cystic fibrosis and pulmonary nodules. Previous studies have reported an adult effective dose of 0.12-0.13 mSv for chest tomosynthesis. The aim of this study was to determine the paediatric effective dose from the dose-area-product. During a 3-y period, 38 children

The Intergenerational Transmission of Schooling: Are Mothers Really Less Important than Fathers?

There is a “puzzle” in the literature on the intergenerational transmission of schooling, where twin studies emphasize the importance of fathers’ schooling, whereas IV-studies often emphasize the importance of mothers. We provide new evidence on this “puzzle” using register based Swedish data on the largest sample of twins used so far in the literature. In contrast to previous twin studies, our re

Search for contact interactions and large extra dimensions in dilepton events from pp collisions at root s=7 TeV with the ATLAS detector

A search for nonresonant new phenomena, originating from either contact interactions or large extra spatial dimensions, has been carried out using events with two isolated electrons or muons. These events, produced at the LHC in proton-proton collisions at root s = 7 TeV, were recorded by the ATLAS detector. The data sample, collected throughout 2011, corresponds to an integrated luminosity of 4.9

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types.

BACKGROUND: Serology for human papillomaviruses (HPV) types -16 and -18 is established as an important tool for studies of HPV vaccinology and epidemiology. However, as there are a large number of oncogenic genital types of HPV there is a need for development of high-throughput, validated HPV serological assays that can be used for more comprehensive seroepidemiological studies and for research on

Simultaneous Visualization of Water and Hydrogen Peroxide Vapor Using Two-Photon Laser-Induced Fluorescence and Photofragmentation Laser-Induced Fluorescence

A concept based on a combination of photofragmentation laser-induced fluorescence (PF-LIF) and two-photon laser-induced fluorescence (LIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor. Water detection is based on two-photon excitation by an injection-locked krypton fluoride (KrF) excimer laser (248.28 nm), which induces broadband f

Early stages of spinodal decomposition in Fe-Cr resolved by in-situ small-angle neutron scattering

In-situ, time-resolved small-angle neutron scattering (SANS) investigations of the early stages of the spinodal decomposition process in Fe-35Cr were performed at 773 and 798K. The kinetics of the decomposition, both in terms of characteristic distance and peak intensity, followed a power-law behaviour from the start of the heat treatment (a' = 0.10-0.11 and a '' = 0.67-0.86). Furthermore, the met