Sphingolipids in the gut? Which are the important issues?
Glycosphingolipids and sphingomyelin (SM) are important components of the apical brush border and the Golgi and enclocytic vesicles of the gut epithelium. In particular, glucosylceramide is abundant in the microvilli. Synthesis and degradation of mucosal sphingolipids and targeting of sphingolipids to distinct cell compartments during cell differentiation are thus important features of intestinal