Background: Critical needs for treatment trials in gastroesophageal reflux disease (GERD) include assessing response to treatment, evaluating symptom severity, and translation of symptom questionnaires into multiple languages. We evaluated the previously validated Reflux Disease Questionnaire (RDQ) for internal consistency, reliability, responsiveness to change during treatment and the concordance

I argue that it is not possible to give an adequate account, within a Scanlon-style contractualist moral theory of the moral duties to reciprocate benefits one has received from others and to compensate harms one has done to others. The problem, very simply put, is that there is no room within such a theory for the fact that the content of these obligations must be proportionate to the value of th

Background: Panic Disorder with or without Agoraphobia is a commonly occurring disorder affecting 2-3% of the population in Sweden. Untreated, panic disorder is a chronic condition that significantly increases the risk for psychiatric comorbidity, morbidity and mortality, employment difficulties, and healthcare utilization. Cognitive behavioural approaches are the recommended first-line treatment

Alm är en uppskattad komponent i stadsmiljöer och rekreationsskogar och ett potentiellt betydelsefullt trädslag för skogsbruket. Almar hyser ett stort antal rödlistade insekter, svampar, mossor och lavar, och är därmed ytterst värdefulla för den biologiska mångfalden i svenska ädellövsskogar. Alla våra almar, och samtidigt de arter som är beroende av dem, hotas dock allvarligt av almsjukan.

Conducting robust research in a conflict or post-conflict area is complicated by concern for the researcher‟s safety and the difficulty of reaching remote areas. In this paper we open a new frontier in mixed methods (MM) research by demonstrating how it can be used to address safety concerns. We used qualitative and quantitative work carried out in and outside the conflict zone to overcome the cha

To make individualized counseling possible, valid and reliable measures of physical activity are necessary. In health care, quality must be continuously secured and developed. Follow-up of life-style habits such as physical activity does not differ from monitoring of other treatment in the health care setting. After counseling and appropriate period of time, evaluation should be done to assess if

Type 1 diabetes is a chronic disease characterized by severe insulin deficiency and hyperglycemia, due to autoimmune destruction of pancreatic islets of Langerhans. A susceptible genetic background is necessary, but not sufficient, for the development of the disease. Epidemiological and clinical observations underscore the importance of environmental factors as triggers of type 1 diabetes, current

Climate change poses a serious challenge to sustainable urban development, placing many cities at risk. Climatic conditions are changing to such an extent that the capacity of urban institutions and associated governance systems to deal with climatic extremes and variability is being reduced. New approaches for urban climate change adaptation are thus urgently needed. There is an increasing conse

To test the hypothesis that certain individual, environmental and lifestyle factors are positively associated with beneficial health investment behaviours and oral/periodontal health among adolescents.

OBJECTIVE: Glucose degradation products (GDPs) are important in the outcome of peritoneal dialysis (PD) treatment. 3,4-dideoxyglucosone-3-ene (3,4-DGE) is the most cytotoxic GDP found in conventionally manufactured fluids and may, in addition, be recruited from 3-deoxyglucosone (3-DG). It is not known what happens with those GDPs in patients during PD. The aim of this study was to investigate if t

The intention of this thesis was to evaluate the effects of inflammation at very preterm birth on subsequent morbidity, as well as on the neuro-protective IGF-system. Prospective clinical studies of very preterm infants constituted a base for the evaluation. Temporal changes in levels of cytokines were chosen as markers of an induced inflammatory response and were evaluated together with component

Den fackliga organisationsgraden och kollektivavtalens täckningsgrad redovisas för byggbranschen, handeln, hotell- & restaurangbranschen och städbranschen, liksom för privat sektor i dess helhet för år 2007. Kollektivavtalens täckning redovisas både inklusive och exklusive hängavtal. För byggbranschen och handeln finns även en uppdelning på arbetare och tjänstemän.

Background: The primary aim of this paper is to describe the design of a project evaluating the effects of using a research-based strategy for managing housing adaptations (HAs). The evaluation targets clients' perspectives in terms of activity, participation, usability, fear of falling, fall incidence, use of mobility devices, and health-related quality of life, and determines the societal effect

Hypoxia has occurred intermittently over the Holocene in the Baltic Sea, but the recent expansion from less than 10 000 km(2) before 1950 to > 60 000 km(2) since 2000 is mainly caused by enhanced nutrient inputs from land and atmosphere. With worsening hypoxia, the role of sediments changes from nitrogen removal to nitrogen release as ammonium. At present, denitrification in the water column and s

The history of Danish geographers during the Second World War is almost synonymous with that of Gudmund Hatt (1884–1960), the Professor of Human Geography at Copenhagen University. Hatt was a key figure in the development of Danish geography and assumed the role of a public intellectual, particularly through his geopolitical analyses as they unfolded in a staggering number of radio speeches, newsp

Quantum dots are an important model system for thermoelectric phenomena, and may be used to enhance the thermal-to-electric energy conversion efficiency in functional materials, by tuning the Fermi energy relative to the dots' transmission resonances. It is therefore important to obtain a detailed understanding of a quantum dot's thermopower as a function of the Fermi energy. However, so far it ha

Background: Wnt proteins are important for developmental processes and certain diseases. WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the progression of malignant melanoma. High expression of WNT5A in melanoma tumors correlates to formation of distant metastasis and poor prognosis. This has partly been described by the findings that WNT5A expression in mela

Documenting sources of variation in host viability at pathogen exposure within and among populations is an important task in order to predict host-pathogen evolutionary dynamics. In the present study, we investigated family and population variation in the degree of embryonic infection of the pathogenic fungus Saprolegnia spp., by infecting moor frog (Rana arvalis) eggs from six populations and exp