A section of a biopharmaceutical manufacturing process involving the enzymatic coupling of a polymer to a therapeutic protein was characterized with regards to the process parameter sensitivity and design space. To minimize the formation of unwanted by-products in the enzymatic reaction, the substrate was added in small amounts and unreacted protein was separated using size-exclusion chromatograph

The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran

A one-dimensional model of the process of continuous sedimentation in a clarifier–thickener unit is presented. The governing model is expressed as a system of two nonlinear partial differential equations for the solids volume fraction and the varying settling velocity of the solids as functions of depth and time. This model extends the well-known model for the dynamics of a flocculated suspension

This work proposes and demonstrates an acoustic trapping system where the trapping frequency is automatically determined and can be used to analyse changes in the acoustic trap. Critical for the functionality of this system is the use of a kerfed transducer that removes spurious resonances. This makes it possible to determine the optimal trapping frequency by analysing electrical impedance. It is

Affinity proteomics, represented by antibody arrays, is a multiplex technology for high-throughput protein expression profiling of crude proteomes in a highly specific, sensitive, and miniaturized manner. The antibodies are individually deposited in an ordered pattern, an array, onto a solid support. Next, the sample is added, and any specifically bound proteins are detected and quantified using m

We report on theoretical results of magnetic field induced transitions (MITs) in Ne- and Be-like ions without nuclear spin for two applicalions. Firstly, MITs are promising candidates in the determination of magnetic fields in plasmas. In our work on Ne-like ions we present accurate theoretical MIT rates for 2p(6 1)S(O) - 2p(5)3s 3P(O),2 [11. Purthermore, for Be-like ions, it has been proposed to

Introduction: The study aimed to investigate different aspects of cognition using the Cognitive Assessment Battery (CAB) in community-dwelling older adults aged 85 years. We also investigated the eventual influence of sex on the results and aimed to identify predictors for further cognitive decline after 1 year. Methods: CAB consists of 10 subtests covering the cognitive domains of speed and atten

Erythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection. There is a predominance of blood group O in malaria-endemic regions, and several lines of evidence suggest that ABO blood groups may influence the outcome of P. falciparum infection. Based on the hypothesis that enhanced innate clearance of infected polymorphic eryth

Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-

Abstract in UndeterminedThis paper contains an analysis of the concept of nondirectivity, a discussion of some arguments against the possibility of being nondirective, and a concluding argument that nondirectivity/directivity represents a basic dimension of therapeutic relating. First, it is argued that nondirectivity should be seen as an attitude rather than a set of behaviors, and that therapeut

This article deals with linear operators T on a complex Hilbert space , which are bounded with respect to the seminorm induced by a positive operator A on . The A-adjoint and A 1/2-adjoint of T are considered to obtain some ergodic conditions for T with respect to A. These operators are also employed to investigate the class of orthogonally mean ergodic operators as well as that of A-power bounded

The neoliberal notion of employability has risen to prominence over the past 20 years, having been positioned as the crux of national, organizational and individual prosperity. To be employable, individuals are increasingly called upon to be self-reliant; aligning themselves to the conditions of an ostensibly fast-moving and precarious global economy. This special issue of ephemera calls attention

Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and a critical element of cholesterol metabolism. To better elucidate the role of apoA-I structure-function in cholesterol metabolism, the conformation of apoA-I's N-terminus (residues 6-98) on nascent HDL was examined by electron paramagnetic resonance (EPR) spectroscopic analysis. A series of 93 apoA-I

A new ReaxFF reactive force field has been developed to describe reactions in the Ti-O-H system. The ReaxFF force field parameters have been fitted to a quantum mechanical (QM) training set containing structures and energies related to bond dissociation energies, angle and dihedral distortions, and reactions between water and titanium dioxide, as well as experimental crystal structures, heats of f

The paper examines the ways in which states facilitate 'new enclosures' of natural resources, and the challenges of this as a strategy of development and environmental sustainability. We argue that enclosures introduce significant changes in property regimes, which redefine conditions for the access and control of land and forest, especially for tribal and indigenous communities. In this context,

A long-standing problem in the Ordovician stratigraphy of south-eastern Norway has been to the relations between the Mjosa Formation in the Lake Mjosa region and coeval strata in the Oslo region. The recent discovery of the globally distributed Guttenberg delta(13)C excursion (Guttenberg Isotopic Carbon Excursion) in the Mjosa region provided the impetus to search for this excellent chemostratigra

In this article, we study 19-year-olds in Sweden (n = 2,942) with and without an immigration background (Iran, Yugoslavia, and Sweden). We follow-up on a recent study, which shows that religion and happiness tend to be positively associated at the individual level only in countries with high aggregate levels of religiosity and proposes that what affects happiness is not religiosity per se but conf