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A Clinical Scoring Algorithm for Determination of the Risk of Tuberculosis in HIV-Infected Adults: A Cohort Study Performed at Ethiopian Health Centers.

The World Health Organization (WHO) tuberculosis (TB) symptom screening instrument (WHO-TB) can identify human immunodeficiency virus (HIV)-infected individuals at low risk of tuberculosis (TB); however, many patients report WHO-TB symptoms and require further TB investigations. We hypothesized that further clinical scoring could classify subjects with a positive WHO-TB screening result (WHO-TB(+)

Dynamic manufacturing costs — Describing the dynamic behavior of downtimes from a cost perspective

Downtimes in a manufacturing cell, a production line or an individual machine are characterized by a complex statistical behavior that their frequency and duration display. The work reported here concerns likenesses and differences between various statistical distributions that apply to functional times (TBF) and downtimes (DT) in connection with different discrete manufacturing processes. The TBF

Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma.

Mouse anticoagulant protein C (461 residues) shares 69% sequence identity with its human ortholog. Interspecies experiments suggest that there is an incompatibility between mouse and human protein C, such that human protein C does not function efficiently in mouse plasma, nor does mouse protein C function efficiently in human plasma. Previously, we described a series of human activated protein C (

Breast tomosynthesis: Accuracy of tumor measurement compared with digital mammography and ultrasonography.

Background: Mammographic tumor size measurement can be difficult because breast structures are superimposed onto a two-dimensional (2D) plane, potentially obscuring the tumor outline. Breast tomosynthesis (BT) is a 3D X-ray imaging technique in which low-dose images are acquired over a limited angular range at a total dose comparable to digital mammography (DM). These low-dose images are used to m

Microsoft till rakning

Ärendet väcker en rad konkurrensrättsliga frågor: Vilken marknad berörs – en bredare plattformsmarknad eller olika marknader för mjukvaruprogram? Är det dominerande företagets skyldigt att på konkurrensrättslig grund dela med sig immaterialrättsligt skyddad kunskap? Vilka effekter ger dessa skyldigheter för informationsflöde mellan konkurrenter - löser myndigheternas bedömning ett problem för att

Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis.

Background: Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large r

Speech and Speech-Related Quality of Life After Late Palate Repair: A Patient's Perspective.

Many patients with cleft palate deformities worldwide receive treatment at a later age than is recommended for normal speech to develop. The outcomes after late palate repairs in terms of speech and quality of life (QOL) still remain largely unstudied. In the current study, questionnaires were used to assess the patients' perception of speech and QOL before and after primary palate repair. All of

Cyclin A Is a Proliferative Marker with Good Prognostic Value in Node-Negative Breast Cancer.

BACKGROUND: Proliferative markers are not recommended as prognostic factors for clinical use in breast cancer due to lack of standardization in methodology. However, proliferation is driving several gene expression signatures emphasizing the need for a reliable proliferative marker for clinical use. Studies suggest that cyclin A is a prognostic marker with satisfying reproducibility. We investigat

What factors affect life satisfaction (LS) among the oldest-old?

Few studies have examined the association between LS in the oldest-old and not only health-related, but also psychological and socio-economical factors. The aim of this study was to examine LS in relation to functional capacity, locus of control (LoC) health status and other factors previously known to influence LS in the oldest-old. The study population consisted of 681 individuals aged 78-98 yea

Sleep and recovery in physicians on night call: a longitudinal field study.

ABSTRACT: BACKGROUND: It is well known that physicians' night-call duty may cause impaired performance and adverse effects on subjective health, but there is limited knowledge about effects on sleep duration and recovery time. In recent years occupational stress and impaired well-being among anaesthesiologists have been frequently reported for in the scientific literature. Given their main focus o