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Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia

Atypical lipomatous tumors (ALTs) are characterized by supernumerary ring chromosomes and/or giant marker chromosomes, which typically are composed of interspersed, amplified 12q-sequences, are C-band negative, lack a-satellite sequences, and display high copy numbers of several oncogenes, including HMGA2 (a.k.a. HMGIC) and MDM2, from the 12q13-15 region. In the present study, we report the cytoge

Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists

Background: Existing studies of solid cancers in rheumatoid arthritis ( RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s. Objective: To depict the cancer pattern of contemporary patients with RA, from updated risk data from prevalent and incident RA populations. To understand the risk of solid cancer after tumour necrosis factor (TNF)

Combined alpha-interferon and ribavirin treatment in chronic hepatitis C: a pilot study

16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 2

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Abstract in French L'objectif de cette étude exploratoire est de voir si l'utilisation des formes interlangagières du type "je parlE" ou "je veux habite" par des apprenants suédophones adultes du français langue étrangère seraient influencées par la fréquence des formes dans l'input. L'étude est faite à partir de données de production orale (apprenants) et de données du français parlé (input).

Achalasia: A vagal disease

Background: Achalasia is considered to be a primary motor disorder of the oesophagus. However, there is increasing evidence to suggest extra- oesophageal involvement in this disease. Vagal disturbances at different levels and extra- oesophageal dysmotility have been reported in several studies. The aim of this study was to examine cardiovascular reflexes in patients with achalasia further to evalu

Hip fractures in Hungary and Sweden - differences in treatment and rehabilitation

Data of 1,337 consecutive hip fracture patients were registered during I year within a prospective comparative multicenter study comparing osteosynthesis techniques and rehabilitation results in Budapest, Hungary, in Sundsvall, northern Sweden, and in Lund, southern Sweden. In Budapest the mean age was 4-5 years lower than in Sweden, and more patients lived in their own home (91% versus 70% and 62

Teloschisteaceae and Parmeliaceae - A review of the present Problems and challenges in lichen systematics at different taxonomic levels.

Problems in classification of main systematic groups are discussed for lichenized ascomycetes exemplified mainly with the Teloschistaceae and Parmeliaceae. Different criteria for delimiting genera and species in these two families are discussed. The lack of separating infraspecific taxa for assigning evolutionary divergence is obvious in both families. The subspecific category is rarely used in li

Wishing, choosing and wanting. On the decision to have a child

Falling birth rates within the European Union have given rise to a number of studies, trying to analyse and interpret why women (and men) choose not to have (many) children. One attempt in this direction is made by an ongoing EU-project, involving eight countries, including Sweden. Qualitative interviews focusing on couples' decisions to have- or not have - children have been carried out in each c

Inter-annual and seasonal variations of energy and water vapour above Pinus sylvestris in the Siberian middle taiga

Long-term eddy covariance measurements of energy and water fluxes and associated climatic parameters were carried out above a Scots pine (Pinus sylvestris) forest in the middle taiga zone of Central Siberia. Data from June 1998 through October 2000 are presented. With the exception of winter 1998/1999, data collection over this period were more or less continuous. A distinct seasonality in surface

Morphologies and droplet sizes of alkyd-acrylic hybrids with high solids content

Alkyd-acrylic hybrids having final solids content of 75-80% were prepared by dropping alkyd resin into an acrylic dispersion. The resulting suspo emulsion structures and the alkyd droplet sizes in the hybrids were dependent on the preparation procedure as well as the interfacial tension between the two liquid phases, sigma(12), the shear rate, gamma, the latex/alkyd ratio and the viscosity ratio,

Diffractive photoproduction of psi(2S) mesons at HERA

Results on diffractive photoproduction of psi(2S) mesons are presented using data collected between 1996 and 2000 with the H1 detector at the HERA ep collider. The data correspond to an integrated luminosity of 77 pb(-1). The energy dependence of the diffractive psi(2S) cross section is found to be similar to or possibly somewhat steeper than that for J/psi mesons. The dependences of the elastic a

Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen

An amino-terminal region of a, chain of type IV collagen noncollagenous domain [alpha(3)(IV)NC1] that induces experimental autoimmune glomerulortephritis (EAG) in rats has been identified. Only recombinant antigens that contain a nine-amino acid (AA) span of alpha(3)(IV)NC1, consistent with a T cell epitope, could induce EAG. It was hypothesized that synthetic peptides of this region should induce