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Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Unlike glucose, the sub-optimal xylose utilization in recombinant Saccharomyces cerevisiae strains may stem from an unusual signaling response that is not adapted to detecting xylose as a fermentable substrate. We hypothesize that the membrane receptor Snf3p, known for sensing extracellular low glucose levels, may contribute to xylose recognition. To test this, we explored the effect of SNF3 inact
Using terahertz and transient absorption spectroscopy, carrier dynamics in organo halide perovskite solar cell is probed. Charge generation is <100 fs, followed by 2 ps charge formation with balanced electron hole mobility of 20 cm2V-1s-1.
Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients
The thesis is devoted to sharp embeddings from Soblolev spaces into Lebesque spaces in one dimension. The paper included in the thesis concerns the embedding from Sobolev spaces of functions that have square integrable derivatives of integer order k into the space of Lebesgue integrable functions (p=1). The main result is the sharp constant and the explicit extremal functions given by the Landau k
In the era of artificial intelligence of things (AIoT), distributed processing on local devices is growing in popularity. This stems from the need to reduce data transfer to and from central servers, with concerns about privacy and latency encouraging the processing of AI applications on edge devices. However, the computational demands of these applications require an increase in the processing ca
We obtain sharp embeddings from the Sobolev space (Formula presented.) into the space (Formula presented.) and determine the extremal functions. This improves on a previous estimate of the sharp constants of these embeddings due to Kalyabin.
The recognized importance of systemic and dynamic perspectives on both AI and innovation management calls for the retheorization to support the AI technology adoption in innovation management. As extant knowledge about a systems approach to realize dynamic roles of both augmentation and automation of AI-human collaboration in innovation management is limited, this study aims to explore how to leve
This chapter explores the evolution and effectiveness of Sweden's climate policy mix for decarbonizing the transport sector—a major contributor to national greenhouse gas (GHG) emissions. Despite early leadership in climate policy, Sweden faces challenges in aligning policy implementation with ambitious goals, such as a 70 % reduction in transport emissions by 2030. The chapter shows that Sweden's
The purpose of the present paper is to describe and discuss the concept of hunter mode, as introduced by Meidell (2022) in her autobiographical description of anorexia nervosa. Hunter mode is a sought-after state that is reached through self-starvation and that transforms a person’s experiences into a crystal-clearperception and a sense of vitality. Although partly touched upon already by Hilde BrThe purpose of the present paper is to describe and discuss the concept of hunter mode, as introduced by Meidell (2022) in her autobiographical description of anorexia nervosa. Hunter mode is a sought-after state that is reached through self-starvation and that transforms a person's experiences into a crystal-clear perception and a sense of vitality. Although partly touched upon already by Hilde B
Social services are adapting to an increasingly digital environment, with municipalities expectedto engage citizens through digital channels. This study investigates how clients seeking social as-sistance perceive and use digital tools as well as the challenges and opportunities that arise whenimplementing such technologies in line with public service values. The analysis draws on municipaldigitalSocial services are adapting to an increasingly digital environment, with municipalities expected to engage citizens through digital channels. This study investigates how clients seeking social assistance perceive and use digital tools as well as the challenges and opportunities that arise when implementing such technologies in line with public service values. The analysis draws on municipal digit
In humanitarian settings, Gender-Based Violence (GBV) is a cause of human rights violations, notably affecting women in vulnerable situations. Migration crises, particularly those leading to the displacement of individuals, further aggravate the vulnerability of women. Recent years have seen a feminization of migration, marked by the higher influx of women migrating, highlighting the need for grea
Grön vätgas har lagts fram som en lösning på en av vår tids största utmaningar: Att klara av världens energiförsörjning samtidigt som de fossila bränslena avvecklas. Framför allt i sektorer som industriell kemikalieproduktion och långdistans-transport, där övergången till förnybar elektricitet är svårare. Grön vätgas produceras genom elektrolys, där en elektrisk ström driver den annars icke-spontaDue to increasing global energy demands and a need to move away from non-renewable energy sources, green hydrogen is now being considered as a possible replacement for fossil-based energy sources. Especially in “hard-to-abate” sectors, such as steel and petrochemical production, and long-distance transport, where the change to renewable electricity is more difficult. Green hydrogen is produced thr
With rising interest rates increasing the cost of capital, businesses are focusing on reducing expenses. Tied-up capital, largely represented by inventory, is a critical cost driver. Therefore, optimizing inventory levels is crucial for controlling capital costs. Inventory levels consist of cycle stock and safety stock. Cycle stock covers average demand during replenishment, while safety stock mit
This article classifies the option hedging strategies of investment banks, explains why dynamic hedges produce hedge errors in imperfect markets, and studies the magnitude and direction of hedge errors produced by different types of options under different hedging strategies. With the help of deep learning models, we predict prices in the next day and actively hedge, overcoming the losses caused b
Denna studie undersöker faktorer som påverkar bildandet av energigemenskaper och utbredningen av eldelning i Sverige. De regulatoriska omständigheterna, samhällsnyttorna och nyttorna utifrån en fastighetsägares perspektiv undersöks genom intervjuer med experter och aktörer inom fastighetssektorn. Resultaten visar att det sker en förändring i vad elanvändare efterfrågar från elsystemet, att flexibi
