Sökresultat

Two hydrogen-bonding monomers containing tetraethylene glycol (TEG) chains have been synthesized and characterized. The monomers are based on a bicyclic scaffold appended with either 4H-bonding benzyl-substituted ureidopyrimidinone motifs or 2H-bonding unsubstituted pyrrole-fused ureidopyrimidinone motifs, with the TEG chains introduced with the aim of developing amphiphilic monomers soluble in no

Objective: To characterize patients with protein-losing enteropathy (PLE) diagnosed before age 18 years within a nationwide Swedish Fontan cohort. Methods: Surgical records and medical charts were reviewed for all patients born after January 1, 1993, who underwent Fontan completion before January 1, 2021. Results: Among 573 reviewed patients, 28 (4.8%) developed PLE. The median time to onset of PL

Glutathione is a major component of the cellular antioxidant system, providing a means of controlling redox homeostasis and affording protection against oxidative damage. Proton magnetic resonance spectroscopy (MRS) offers insights into brain metabolism by enabling the noninvasive quantification of metabolites. Previous studies have demonstrated that the neurotransmitters glutamate and GABA detect

The global climate change governance landscape is rapidly evolving. Non-state actors and institutions increasingly challenge the formal authority of the United Nations Framework Convention on Climate Change (UNFCCC), operating in parallel with its intergovernmental processes. In particular, multi-stakeholder partnerships (MSPs) carry out several policy functions, becoming established actors within

Major depressive disorder (MDD) is associated with reduced quality of life and relapse risk. However, few studies have investigated how quality of life is associated with cognitive deficits following MDD and is affected by cognitive training. This study investigated the long-term effects of computer-based working memory training (CWMT) on health-related quality of life (HRQL) in remitted MDD, and

Background Anorexia nervosa is associated with high personal and financial costs for sufferers, carers and society in general, but little is known about the long-term health economic burden. Aims To examine healthcare utilisation, social assistance, sick leave and disability pension in individuals with anorexia nervosa over a period of 30 years. Method Fifty-one individuals with adolescent-onset a

Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality. Methods: Bloo

The functional decline of hematopoietic stem cells (HSCs) with age is a well-documented phenomenon, associated with various health complications, including anemia, impaired immune responses, and chronic inflammation. This dysfunction can contribute to the onset of hematological disorders such as myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML

Self-compassion is associated with positive mental health outcomes and may buffer against negative self-evaluations and emotional difficulties. Nevertheless, studies among athletes often explore self-compassion in specific groups in isolation (e.g., women athletes) (Röthlin et al., 2019). The aims of this study were to 1) explore whether the relationship between gender and composite scores and spe

Background Virtual reality (VR) technology is increasingly being explored as a tool to help reduce aggressive behavior in forensic psychiatric settings. This study aimed to explore the experiences of therapists and ward staff participating in a pilot study of a VR-assisted aggression treatment within a Swedish maximum-security forensic psychiatric clinic.Methods A qualitative, descriptive, and exp

Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) is increasingly prevalent in aging populations. Dietary anthocyanin has been shown to exert metabolic benefits in aging and age-associated metabolic disorders. However, its role in protecting against age-dependent hepatic steatosis and the underlying mechanisms remain poorly defined.Approach and Results: In 18-mo

Protein degradation is a regulated process that reshapes the proteome and generates bioactive peptides. Peptidomics and degradomics enables large-scale measurement of these peptides, yet most data analyses approaches treat peptides as isolated endpoints rather than intermediates produced by sequential cleavage. Here, we introduce degradation graphs, a probabilistic framework that represents proteo

Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin

IMPORTANCE: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.OBJECTIVES: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate

How do bribes and lobbying distort judgment? In our experiment, referees are tasked with judging a worker’s performance, and awarding a bonus to workers who score above a certain threshold. We find that bribes and lobbying are both distortionary, but in different ways. Whereas lobbying increases the number of workers receiving a bonus, bribes weaken the relationship between performance and success

We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGET