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Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia

Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocyto

V2O3(0001) surface terminations: from oxygen- to vanadium-rich

Well-ordered epitaxial V2O3(0 0 0 1) films (thickness > 80 Angstrom) have been prepared on the clean Rh(1 1 1) surface and investigated with scanning tunnelling microscopy, low-energy electron diffraction, high-resolution electron energy loss spectroscopy and high-resolution X-ray photoelectron spectroscopy with synchrotron radiation. Atomically flat V2O3(0 0 0 1) surfaces, terminated by vanadyl (

Study of the reactivity and in vitro bioactivity of Sr-substituted alpha-TCP cements

In this study the effect of strontium substitution on the hydrolysis of alpha-tricalcium phosphate (alpha-TCP) toward the formation of calcium deficient hydroxyapatite (CDHA) was investigated. For that purpose substituted alpha-TCP powders with 1, 5 and 10 mol% Sr substitution for Ca were synthesized by reacting at 1500 degrees C stoichiometric amounts of CaCO3, SrCO3, and Ca2P2O7, followed by rap

Improved meal-related insulin processing contributes to the enhancement of B-Cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes

The aim of this study was to evaluate the contribution of insulin processing to the improved meal-related B-cell function previously shown with the DPP-4 inhibitor vildagliptin. Fifty-five patients with type 2 diabetes (56.5 +/- 1.5 years; BMI=29.6 +/- 0.5kg/m(2); FPG = 9.9 +/- 0.2 mmol/l; HbA1c=7.7 +/- 0.1 %) were studied: 29 pateients were treated with vildagliptin and 26 patients with placebo,

Radiographic joint space in normal acromioclavicular joints

The acromioclavicular joint space in standard antero-posterior images of 151 normal subjects was measured. The joint space was significantly wider in men. There was a highly significant reduction of the joint space with age in both men and women and in persons past 60 a joint space of 0.5 mm or less is not pathological. A joint space wider than 7 mm in men and 6 mm in women is abnormal. The measur

Capacity of MIMO systems with antenna selection

We consider the capacity of multiple-input multiple-output systems with. reduced complexity. One link-end uses all available antennas, while the other chooses the L out of N antennas that maximize capacity. We derive an upper bound on the capacity that can be expressed as the sum of the logarithms of ordered chi-square-distributed variables. This bound is then evaluated analytically and compared t

Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled

The Role of Hox Transcription Factors in the Regulation of Hematopoiesis

Hematopoiesis is a lifelong, dynamic process, originating from a low number of hematopoietic stem cells (HSCs) residing in the adult bone marrow with the ability to self-renew and generate all blood lineages throughout life. Recent findings have demonstrated that the Homeobox (Hox) transcription factors are important regulators of both normal and malignant hematopoiesis, controlling proliferation,

Telomerase in yeast

The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence. The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae-with regular and irregular telomeric sequences, respectively-have now been identified and characterized. The S. cerevisiae activity required the telomerase RNA gene TLC1 but not the EST1 gene, bo

Calculation of the near field of aggregates of arbitrary spheres

We study a numerical method of calculating the near field of ensembles of arbitrary spheres by extending Mie theory. A recursive method based on the orders of scattering is presented. This method represents a concise way to calculate the near field of aggregates of any number of arbitrary spheres. Numerical examples are given to show its validity. (C) 2004 Optical Society of America.

Interieukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women

Interleukin 6 (IL-6) is a multifunctional cytokine and a potent stimulator of bone resorption and has been implicated in the pathogenesis of osteoporosis in postmenopausal women. The aim of this study was to investigate if a functional JL-6 promoter polymorphism (-174) was related to bone mass and fractures in a cohort consisting of 964 postmenopausal Caucasian women aged 75 years. Bone mineral de

Effects of unloading of multiple necking in tensile bars

The distribution of necks in slender structures obtained using high rate deformation often differs from the distribution obtained under quasistatic conditions. Initial thickness imperfections are often used to initiate necking at certain locations along a specimen surface. At sufficiently large deformation rates, necks may develop at sites that correlate weakly or not at all with the sites of the

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Abstract in Danish Formål: Formålet er at beskrive tuberkulosens (tbc.) epidemiologi i Danmark de sidste 25 år, specielt udviklingen i den danske befolkning. Metode: Et registerstudie af anmeldte tilfælde af tbc. i Danmark 1972-1996: Fra 1970-1989 i DIKE's register, fra 1990-1996 i EPI-registeret, epidemiologisk afd., Statens Serum Institut. Resultater: tbc.-incidensen faldt jævnt fra 1972 indtiThe present study is based on notified cases of tuberculosis (TB) in the National tbc. register 1972-1996. A decline in Tb incidence was seen from 1972 and until the mid-1980's. Subsequently the trend has reversed due to an increasing number of TB cases in foreigners. In 1996, 60% of all cases of TB in Denmark were found in foreigners reflecting the rising number of refugees and their families arr