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The relative size and relaxation of the invisible pool of bound spins (T1b) underlying magnetization transfer (MT) was quantified in eight subjects in vivo at 1.5 T from progressive saturation experiments using repetitive MT pulses. The evolution of the binary spin–bath was sampled by increasing the repetition period from 8 to 200 ms. Single-shot echo-planar images at TE=50ms were evaluated in the
