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PURPOSE: Subterminal intracranial Internal Carotid Artery (ICA-I) occlusion is a lesser-known stroke subtype which may delay access to endovascular thrombectomy (EVT). We compared clinical presentation, imaging characteristics, treatment delays, outcomes, and diagnostic accuracy between EVT-treated patients with ICA-I and carotid terminus (ICA-T) occlusions.METHODS: All EVT-treated patients with i
Background: Intracerebral hemorrhage (ICH) in the posterior fossa, that is, cerebellum and brainstem, often has a poor prognosis. Treatment options are limited. However, primary preventive measures may have changed during the last decades. We aimed to study the hospitalization-based incidence and characteristics of posterior fossa ICH and examine whether these changed during a 13-year period. Meth
Background: The external environment, including toxicants, remains largely unexplored in celiac disease (CeD). Some of the per- and polyfluoroalkyl substances (PFAS) have immune-toxic properties and may play a role in the development of autoimmune diseases.Methods: In case-control studies nested in the Norwegian MoBa and the Finnish DIPP cohorts, children with CeD were identified by case-finding (
Achieving negative resection margins (R0) is central to curative surgery for pancreatic ductal adenocarcinoma (PDAC), but its prognostic relevance in multivisceral resections has been unclear. Using the largest international registry of multivisceral pancreatic resections, we performed a propensity score-matched analysis comparing R0 and R1 resections in patients undergoing multivisceral resection
An in vitro model of classical conditioning could improve our understanding of underlying mechanisms thanks to controlled pharmacological manipulation and negligeable perturbations from external networks. Here, using mice cerebellar slices and patch clamp recordings, we present a protocol for classical conditioning of Purkinje cells in vitro at room temperature. Repeated pairing of a parallel fibe
DN DEBATT.Politiker pratar gärna om hur mycket mer pengar medelklassen får i fickan av skattesänkningar, men statistiken visar att detta inte stämmer. Tittar man på balansen mellan inbetalad skatt och utbetalade ersättningar ser man att medelklassen tappat mest under 2000-talet, skriver Niklas Altermark och Anton Svensson, forskare vid Lunds universitet.
STUDY DESIGN: Psychometric study.OBJECTIVES: To evaluate the data completeness, data distribution and ceiling/floor effects, internal consistency and convergent validity of the Swedish versions of the Spinal Cord Independence Measure IV (s-SCIM IV) and the Spinal Cord Independence Measure Self-report (s-SCIM-SR).SETTING: Swedish inpatient and outpatient spinal cord injury (SCI) rehabilitation.METH
PURPOSE: Deleterious effects from concomitant gradients are amplified at lower field strengths and stronger gradients. We aimed to show the signal errors caused by concomitant gradients across a wide range of hardware configurations and propose corrections that can be applied during experimental design and analysis.THEORY AND METHODS: We derived a compact but accurate expression for concomitant gr
BackgroundClinical monitoring of patients with heart failure or cardiomyopathy is facilitated by detailed assessment of cardiac loading conditions. Specifically, alterations in preload and afterload may unmask pathology through effects on ventricular pressure–volume (PV) relations. Therefore, the aim was to assess non-invasive PV loops during left ventricular load manipulation in healthy participa
The increasing demand for accessible phosphorus sources, essential for plant growth, is placing growing pressure on both industry and academia. Here, we investigate nanoplatelets as carriers for phosphate species, using Laponite® as a model system for sprayable phosphorus formulations. We examine how phosphate species chain length (1, 2, 3, 14, 60, and 130 monomers) governs dispersion stability an
Abstract.– In ectothermic invertebrates, high temperatures generally accelerate developmental rates and decrease adult body sizes. However, such temperature effects on body size could have contrasting fitness effects in the two sexes, as under certain circumstances in some species small males may have higher mating success, but large female insects almost invariably have higher fecundity. Here we
The modulation of charge carrier dynamics by lattice motion is an inherent characteristic of photovoltaic materials. Increasing research interest in understanding and controlling this complex interaction has continuously grown for the past few years with the aim of further improving solar cells’ device performance. This review analyses recent studies on solution-processed organic polymers, hybrid
Advanced Parkinson’s disease (APD) often presents challenges such as irregular gastric absorption and delayed gastric emptying, leading to significant and unpredictable fluctuations in both motor and non-motor symptoms. Our study is a real-world, open-label study of the tolerability and efficacy of subcutaneous infusion of Foslevodopa/Foscarbidopa (FL/FC) focus on comparing White Caucasian patient
The entorhinal cortex is the first region to develop tau pathology in Alzheimer's disease and primary age-related tauopathy, yet the reasons for this selective vulnerability remain unclear. We developed a computational model in which neuronal activity and amyloid-β (Aβ) modulate tau transport, hypothesizing that this mechanism explains entorhinal vulnerability to early tau pathology. The model com
Background: The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) pulmonary hypertension definition only consider resistant right ventricular (RV) load (pulmonary vascular resistance [PVR]), but not pulsatile load (pulmonary artery compliance [PAC]) known to be important. Objectives: The authors aimed to compare severity-grading of RV afterload using the current pulmonary
