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In T cells PKC theta mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKC theta regulates NF kappa B transactivation by examining PKC theta/beta single and double knockout mice and observed a redundant involvement of PKCh and PKC beta in this signaling pathway. Mechanistically, we define a PKC theta-CYLD protein compl

Popular Abstract in Swedish Ordet vaskulit betyder kärlinflammation och med systemisk vaskulit menas inflammation i blodkärl på flera olika ställen i kroppen. Vaskulit kan drabba alla typer av kärl i kroppen, både stora och små, artärer, vener och kapillärer. Inflammationen i kärlväggen kan leda till att kärlet skadas och att blodförsörjningen till olika organ då kan bli bristfällig. Symtomen vid ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis- dying neutrophils surrounding small blood vessels. Previous studies have shown increased plasma PR3 and increased proportion of neutrophils expressing plasma membrane-associated PR3 (mPR3+). Neutrophils were isolated by polymorphprep and membrane expression was measured by FACS. Plasma PR3, pro-PR3 and cytokines were

This paper presents an offline frequency-domain nonlinear and stochastic identification method for equivalent model parameter estimation of high-voltage pulse transformers. Such kinds of transformers are widely used in the pulsed-power domain, and the difficulty in deriving pulsed-power converter optimal control strategies is directly linked to the accuracy of the equivalent circuit parameters. Th

Background: Calreticulin (CRT) is a ubiquitous ER protein involved in multiple cellular processes in animals, such as protein folding and calcium homeostasis. Like in animals, plants have evolved divergent CRTs, but their physiological functions are less understood. Arabidopsis contains three CRT proteins, where the two CRTs AtCRT1a and CRT1b represent one subgroup, and AtCRT3 a divergent member.

Aim: The aim of this research was to explore and evaluate the new expected identities of unmarried urban women in China, by analyzing the changes in the marriage law in the last 60 years, particularly in property division in the case of divorce. Methodology: The paper proceeded under the qualitative method and designed a case study in Chengdu. The data from books, journals, policies, newspapers an

In 2003 the concept of Application Service Provision (ASP) as a way to provide Enterprise Systems (ES) to Small and Medium sized Enterprises (SMEs), “hyped”. In 2013 we saw the same “hype” but now with the Software as a Service (SaaS) model. Even if labelled differently, these concepts seem to mean the same and so, in this paper, we explore if providers perspective for the adoption of external pro

The article describes and analyses the legal framework concerning children’s participation in research in Sweden. Research on children is one way to improve children’s living conditions. For example, there is a need for knowledge about children’s and young people’s situation at home, at school, in community care and in correctional facilities. It is inevitable that there arise both ethical and leg

The present article is a functional analysis of intonation in Russian declarative utterances. Pragmatically relevant tonal patterns and their functions are identified and described. Utterances are analysed in terms of theme and rheme. Theme is signalled by a tonal rise and rheme by a falling tonal gesture. Beside thematic and rhematic tonal gestures, other rising accents in the utterance are ident

In animal models of Parkinson's disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute striatal slices from rodents with unilateral 6-hydroxydopamine (6-OHDA) lesions. Application of the dopa

To address the problems of climate change and energy security, Chinese government strived to develop renewable power as an important alternative of conventional electricity. In this paper, the learning curve model is employed to describe the decreasing unit investment cost due to accumulated installed capacity; the technology diffusion model is used to analyze the potential of renewable power. Com

The dynamic properties of the glomerular filtration barrier (GFB) are of fundamental importance for the understanding of the physiology and pathophysiology of microalbuminuria and proteinuric diseases. In the studies of this doctoral thesis the properties of the rat glomerular filtration barrier were investigated under resting conditions and following a number of challenges using highly sensitive

Atmospheric N deposition is known to severely impact forest ecosystem functioning by influencing soil biogeochemistry and nutrient balance, and consequently tree growth and overall forest health and biodiversity. Moreover, because climate greatly influences soil processes, climate change and atmospheric N deposition must both be taken into account when analysing the evolution of forest ecosystem s

Inhibitors that are generated during thermochemical pretreatment and hydrolysis impair the performance of microorganisms during fermentation of lignocellulosic hydrolysates. In omitting costly detoxification steps, the fermentation process relies extensively on the performance of the fermenting microorganism. One attractive option of improving its performance and tolerance to microbial inhibitors

To be able to successfully measure radiocarbon with accelerator mass spectrometry (AMS) in atmospheric aerosol samples, graphitization of small sample sizes (< 50 µg carbon) must provide reproducible results. At Lund University, a graphitization line optimized for small samples has been constructed. Attention has been given to minimize the reduction reactor volume and each reactor is equipped with

CD8-positive cells might play a crucial role in the therapeutic response to radiation, which has however not been investigated in radioimmunotherapy (RIT). The aim of this study was to evaluate whether cytotoxic T cells affect the response of established tumors and, above all, if they delay or prevent the development of distant metastases after RIT, using an immunocompetent syngeneic rat colon car

A covariance function estimate of a zero-mean nonstationary random process in discrete time is accomplished from one observed realization by weighting observations with a kernel function. Several kernel functions have been proposed in the literature. In this paper, we prove that the mean square error (MSE) optimal kernel function for any parameterized family of random processes can be computed as

Context: Testicular cancer patients are often diagnosed at a young age, and because of the advances in the treatment of this disease, the vast majority have a normal life expectancy after therapy. Thus, recognition of the long-term sequelae of treatment (ie, surgery, radiation therapy, and chemotherapy) is particularly important in these patients. Objective: To review the adverse effects and the r

Popular Abstract in Swedish De medeltida katedralerna har med sina imponerande stenfasader och höga torn fortsatt att fascinera människor genom århundradena, och silhuetterna utgör fortfarande ett framträdande landmärke för den som närmar sig stiftsstäderna. Även interiörerna vittnar om den medeltida prakten även om, i likhet med exteriörerna, mycket har förändrats och försvunnit sedan dess. Lika The purpose of this thesis is to study the function of the cathedral as a devotional milieu and try to recreate lay people´s visits using the keywords Places, Times, Objects and Motifs. Geographically the study is limited to two cathedrals in present-day Sweden: the ones in Linköping and Lund. In this way, cathedrals from two different ecclesiastical provinces (the archbishoprics of Uppsala and Lu