Sökresultat

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar

One of the main beliefs in quality assurance is that this activity – indirectly – will stimulate change in the work practices associated with teaching and learning in higher education. However, few studies have provided empirical evidence of the existence of such a link. Instead, quality assurance has created an unfortunate divide between formal rules and routines, and the daily practices in acade

Popular Abstract in Swedish Ger en ökad fysisk aktivitet bland växande barn bättre skelett- och muskelutveckling och påverkar det i så fall frakturrisken? Benskörhet och låg benmassa medför en ökad risk för frakturer. Låg fysisk aktivitet är också en riskfaktor. En ökad frakturförekomst är i dag ett växande samhällsproblem, och med dessutom en åldrande population samt en generellt mindre fysiskt Osteoporosis and related fractures are a global health problem. Physical activity, especially during growth, has been suggested as a strategy to improve musculoskeletal health in the population. Previous prospective pediatric exercise intervention studies, however, are short-term, mostly covering less than one year and use bone traits as surrogate endpoints for fractures. The Pediatric Osteoporosi

Sverige har en vision om ”netto-noll” utsläpp av växthusgaser till 2050 och är på god väg att nå utsatta delmål för utsläppsreduktioner till 2020. Klimatfrågan är dock långsiktig och det under klimatkonventionen antagna 2-gradersmålet innebär utsläppsåtaganden som sträcker sig till år 2050 och bortom. En långsiktigt effektiv klimatpolitik ska därför utvärderas både efter vilka långsiktiga utveck

I denna uppsats behandlas satsadverbialen inte, nog och visst. De undersöks, var för sig, i två positioner i satsen, nämligen fundamentet och den typiska satsadverbials¬positionen (A1). Syftet är att beskriva adverbialens möjliga betydelser i respektive position. Utifrån hur de, i olika talsituationer och kontexter, inverkar på talarens inställning till satsens proposition i fundamentet och i A1,

We show theoretically that the poor can benefit from price changes induced by higher income inequality. As the number of poor increases, the market for products aimed toward the poor grows, and such products become more profitable. As a result, there are circumstances where an increase in income inequality associates with higher purchasing power of the poor. Using cross-country data on the price o

We have investigated the magneto-resistivity (MR) of FeSe1-xTex superconducting films on MgO substrate. The MR of pure FeSe and slightly Te-substituted films demonstrates regular Lorentz-type magnetic field dependence, MR similar to B-2. In highly Te-substituted samples, however, negative MR contribution due to the weak-localization effect gradually dominates at low temperature, which is consisten

To investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death.

We investigate a new method to place patients into risk groups in censored survival data. Properties such as median survival time, and end survival rate, are implicitly improved by optimizing the area under the survival curve. Artificial neural networks (ANN) are trained to either maximize or minimize this area using a genetic algorithm, and combined into an ensemble to predict one of low, interme

One of the single most cited studies within the field of nonstationary panel data analysis is that of LLC (Levin et al. in J Econom 98:1-24, 2002), in which the authors propose a test for a common unit root in the panel. Using both theoretical arguments and simulation evidence, we show that this test can be misleading unless it is based on the same bandwidth selection rule used by LLC.

The inclusive transverse momentum (p(T)) distributions of primary charged particles are measured in the pseudo-rapidity range vertical bar eta vertical bar <0.8 as a function of event centrality in Pb-Pb collisions at root S-NN = 2.76 TeV with ALICE at the LHC. The data are presented in the p(T) range 0.15 < p(T) <50 GeV/c for nine centrality intervals from 70-80% to 0-5%. The results in Pb-Pb are

Background and Purpose-Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. Methods-The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of Fabry disease. In a secondary analysis of pa

N-15 labeled ammonium, glycine or glutamic acid was injected into subarctic heath soil in situ, with the purpose of investigating how the nitrogen added in these pulses was subsequently utilized and cycled in the ecosystem. We analyzed the acquisition of N-15 label in mycorrhizal and non-mycorrhizal plants and in soil microorganisms, in order to reveal probable differences in acquisition patterns

Introduction: Evidence for the current guidelines for the treatment of patients with chronic total occlusions (CTO) in coronary arteries is limited. In this study we identified all CTO patients registered in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and studied the prevalence, patient characteristics and treatment decisions for CTO in Sweden. Methods and Results: Between Ja

Erysipelas is a common infection that often recurs, but the impact of specific risk factors for reoccurrence remains elusive. In the present study we aimed at clarifying predisposing conditions for reoccurrence.

Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. The ensuing osmotic mitochondrial swelling and loss of bioenergetic function is referred to as the mitochondrial permeabili