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Three recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilanceThree recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilance

Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited

Patients with antineutrophil cytoplasm antibody-associated vasculitis (AAV) requiring dialysis at diagnosis are at risk for developing end-stage renal disease (ESRD) or dying. Shortterm results of a trial comparing plasma exchange (PLEX) to intravenous methylprednisolone (IV MeP) suggested PLEX improved renal recovery. Here we conducted long-term follow-up to see if this trend persisted. A total o

This paper addresses a problem related to control of web servers. Due to architectual issues, relevant measurements can only be taken over a limited part of the server system, which leaves the controller unaware of what happens in buffers proceeding the actual web-server (for instance, in the TCP/IP layers). In earlier presented work we modeled such a system and proved that the unmeasured bufferin

OBJECTIVE - The purpose of this study was to compare the incidence of vascular lower-limb amputation (LLA) in the diabetic and nondiabetic general population. RESEARCH DESIGN AND METHODS - A population-based cohort study was conducted in a representative Swedish region. All vascular LLAs (at or proximal to the transmetatarsal level) performed from 1997 through 2006 were consecutively registered an

Popular Abstract in Swedish De övergripand syftena med dessa studier var att undersöka vilka konsekvenser höftbesvär och höftledsartros har på hälsorelaterad livskvalité, fysisk förmåga och tilltro till egen förmåga. Höftledsartros är ofta förknippad med svår smärta och påverkar både fysiska funktioner och livskvalité. Förekomsten av höftbesvär, i en befolkningsgrupp i södra Sverige, var 32%, och The overall aims of this work were to investigate the consequences of hip disorders and hip osteoarthritis (OA) on health-related quality of life (HRQL) physical function and self-efficacy. The condition, hip OA, is often associated with significant pain and has a strong impact on physical function and quality of life. The prevalence of hip disorders were 32% and among the individuals reporting h

Popular Abstract in Undetermined I den här populärvetenskapliga sammanfattningen berörs avhandlingen Gradient Methods for Large-Scale and Distributed Linear Quadratic Control. Hur kan jetflygplan hålla sig i luften? Hur kan en Segway balansera en människa? Dessa frågor och många fler kan besvaras med hjälp av reglerteknik. Reglerteknik är ett område som behandlar hur man automatiskt styr system oThis thesis considers methods for synthesis of linear quadratic controllers for large-scale, interconnected systems. Conventional methods that solve the linear quadratic control problem are only applicable to systems with moderate size, due to the rapid increase in both computational time and memory requirements as the system size increases. The methods presented in this thesis show a much slower

Entrepreneurship is an emerging research field that has received much scholarly attention in recent decades. Given the global scope of this attention, this article compares entrepreneurship research in China with that in the USA and Europe. Based on publications in Social Science Citation Index and Chinese Social Science Citation Index databases over the past 10 years, we use bibliometric method t

The aim of this study in textile studies and cultural history is to gain a greater understanding of what happened to the division of labour and manufacturing techniques when female fashions changed in the period 1770-1830. This was a time of upheaval as regards fashions, and a change in dress practice. The decades around 1800 were a period of major societal and cultural transformation. Female fash

Pollution induced community tolerance (PICT) has been suggested as an end-point measurement less affected by confounding environmental factors compared to standard methods of microbial growth, activity and community composition. We evaluated the use of PICT to determine Cu toxicity in vineyard soils polluted with Cu based fungicides (25-1120 mg Cu kg(-1)). These soils also varied in pH (4.3-7.3),

The quadratic term in the Taylor expansion at the origin of the backscattering transformation in odd dimensions n >= 3 gives rise to a symmetric bilinear operator B-2 on C-0(infinity)(R-n) x C-0(infinity)(R-n). In this paper we prove that B-2 extends to certain Sobolev spaces with weights and show that it improves both regularity and decay.

Denna rapport baseras på två inventeringar. Dels en inventering av sten- och jordlavar som genomfördes den 25 juli 2009 av Lars Fröberg, dels en inventeringen av skyddsvärda träd som genomfördes mellan 21 oktober och 12 november 2008 av Mattias Lif och Sofie Willman. Jordö är en halvö vid västra delen av Almö som ligger i norra delen av Listerby skärgård. Området är troligtvis ett av de artrikaste

BACKGROUND: ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis, accumulation of unscavenged apoptotic and necrotic neutrophils in perivascular tissues. Dysregulation of neutrophil cell death may contribute directly to the pathogenesis of AASV. METHODS: Neutrophils from Healthy Blood Donors (HBD), patients with AASV most in complete remission, Polycythemia Vera (PV), Sy

Background: Identification of disease-associated single nucleotide polymorphisms (SNPs) in seasonal allergic rhinitis (SAR) may be facilitated by focusing on genes in a disease-associated pathway. Objective: To search for SNPs in genes that belong to the T-cell receptor (TCR) pathway and that change in expression in allergen-challenged CD4+ cells from patients with SAR. Methods: CD4+ cells from pa